Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"University of Toronto" +contributor:("Nauth, Aaron"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of Toronto

1. Gortler, Hilary. The Effect of Bone Marrow-Derived Progenitor Cell Therapy to Improve Fracture Healing in a Diabetic Rat Critical Size Defect Model.

Degree: 2018, University of Toronto

Our study aimed to explore the efficacy of locally implanted endothelial progenitor cells (EPCs) from healthy and diabetic animals on bone defect healing in healthy and diabetic recipients. EPCs seeded on gelatin scaffolds were implanted in surgically created 5mm femoral defects to create six randomized treatment groups. The animals underwent biweekly radiographic assessment until the 10-week endpoint. Post-mortem specimens were analyzed by micro-computed tomography and biomechanics. Most cell-treated healthy animals achieved union by 8 weeks. EPC-treated diabetic animals achieved higher radiographic scores than the diabetic controls. Healthy animals that received diabetic cells demonstrated greater bone volume, fractional bone volume, bone mineral density and biomechanical stiffness to diabetic animals that received diabetic cells but did not significantly differ from healthy animals that received healthy cells. Thus, EPC therapy promotes fracture healing in diabetic animals irrespective of the cell source, though diabetes may decrease their healing capacities compared to treatment-matched healthy animals.

M.Sc.

Advisors/Committee Members: Nauth, Aaron, Medical Science.

Subjects/Keywords: Cell Therapy; Diabetes; EPC; Regenerative Medicine; 0564

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gortler, H. (2018). The Effect of Bone Marrow-Derived Progenitor Cell Therapy to Improve Fracture Healing in a Diabetic Rat Critical Size Defect Model. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91425

Chicago Manual of Style (16th Edition):

Gortler, Hilary. “The Effect of Bone Marrow-Derived Progenitor Cell Therapy to Improve Fracture Healing in a Diabetic Rat Critical Size Defect Model.” 2018. Masters Thesis, University of Toronto. Accessed May 24, 2019. http://hdl.handle.net/1807/91425.

MLA Handbook (7th Edition):

Gortler, Hilary. “The Effect of Bone Marrow-Derived Progenitor Cell Therapy to Improve Fracture Healing in a Diabetic Rat Critical Size Defect Model.” 2018. Web. 24 May 2019.

Vancouver:

Gortler H. The Effect of Bone Marrow-Derived Progenitor Cell Therapy to Improve Fracture Healing in a Diabetic Rat Critical Size Defect Model. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2019 May 24]. Available from: http://hdl.handle.net/1807/91425.

Council of Science Editors:

Gortler H. The Effect of Bone Marrow-Derived Progenitor Cell Therapy to Improve Fracture Healing in a Diabetic Rat Critical Size Defect Model. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91425

.