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You searched for +publisher:"University of Toronto" +contributor:("Bernardini, Marcus Q"). One record found.

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University of Toronto

1. Philp, Lauren. Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers.

Degree: 2018, University of Toronto

Treatment of endometrial cancer consists of surgery ± adjuvant therapy depending on lymph node involvement determined by lymphadenectomy. Targeting lymphadenectomy to patients with known metastases would provide diagnostic and therapeutic benefits while reducing morbidity. Porphysomes are self-assembling nanoparticles made from a multifunctional porphyrin-lipid monomer (pyrolipid) which accumulate preferentially in malignant tissue. Pyrolipid is created through an acylation reaction during which isomerization can occur. A VX2 model of endometrial cancer with retroperitoneal metastases was used to investigate the accuracy of pre-operative 64Cu-Porphysome-enabled PET imaging of lymph nodes and the sensitivity / specificity of in-vivo porphyrin-fluorescence image-guided lymphadenectomy. Pharmacokinetic, biodistribution and biodegradation studies were used to determine differences in Sn1 and Sn2 isomeric Porphysomes. This study demonstrated that Porphysomes are a highly sensitive imaging tool to diagnose primary tumour, metastatic lymph nodes and intra-abdominal metastases and that Sn2 pyrolipid is the optimal isomer for clinical translation due to the preferential biodegradation profile.

M.Sc.

Advisors/Committee Members: Bernardini, Marcus Q, Medical Science.

Subjects/Keywords: Endometrial Cancer; Fluorescence Imaging; Lymphadenectomy; Metastasis; Molecular Imaging; Nanoparticle; 0574

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Philp, L. (2018). Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91426

Chicago Manual of Style (16th Edition):

Philp, Lauren. “Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers.” 2018. Masters Thesis, University of Toronto. Accessed October 23, 2019. http://hdl.handle.net/1807/91426.

MLA Handbook (7th Edition):

Philp, Lauren. “Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers.” 2018. Web. 23 Oct 2019.

Vancouver:

Philp L. Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2019 Oct 23]. Available from: http://hdl.handle.net/1807/91426.

Council of Science Editors:

Philp L. Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91426

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