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You searched for +publisher:"University of Toledo" +contributor:("Modi, Sachin"). Showing records 1 – 3 of 3 total matches.

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University of Toledo

1. Ben Jebara, Marouen. Essays on Biopharmaceutical Supply Chains.

Degree: PhD, Manufacturing and Technology Management, 2015, University of Toledo

An emerging trend in the pharmaceutical industry is the high level of personalization of medicines that firms offer today. Such medications are expected to account for 50% of the amount spent on drugs by 2018. In conjunction with the growth of this new class of medications, firms are also continuing to serve markets for traditional (or small molecule) medications, which are often standardized or mass customized for consumer markets. Managing the diverse portfolio of medications can require different supply chain structures, specifically with respect to distribution channels. For example, the prostate cancer vaccine involves a reverse flow of raw material in the form of patient blood cells from the hospital/physician clinic to the pharmaceutical firm processing centers – a characteristic that is often not seen with traditional medications that are dispensed at the pharmacy or hospital. This has led to a new trend in the distribution channel practices for such medication, i.e. supply chain disintermediation, where the firm engages in a direct sales model, which means that the medication is shipped directly to the patient or the administrating facility (e.g. the physician’s clinic/hospital) instead of being distributed through the traditional channel of wholesalers. In summary, firms today have a choice of structuring their supply chains to have a traditional intermediated distribution channel, a direct disintermediated distribution channel, or combination thereof. However, little research exists that can guide managerial decisions with respect to the appropriate supply chain structure given the portfolio of the firm’s medication offerings. The firm’s choices for product portfolio and supply chain structure for distribution channels raise a critical question of `what is the most appropriate supply chain disintermediation strategy given the firm’s product portfolio?’ Therefore, in this dissertation, the research objective is to address this central question. In addressing this research objective, the dissertation is composed of four distinct essays. The first essay is aimed at answering the above question conceptually. It maps the evolution of the pharmaceutical product paradigm along a continuum of standardized/mass customized/mass personalized products as well as discusses the evolution of the supply chain structure in terms of disintermediation for pharmaceutical firms. Drawing on literature in operations management in the areas of mass customization and supply chain disintermediation, as well as industry practices, the study presents a framework which identifies the appropriate supply chain structure (intermediated vs. disintermediated) given the level of personalization of pharmaceutical products. Additionally, a critical characteristic of personalized (biologics) medicine is its time sensitive nature and consequent market mediation costs that make logistical design a critical issue. To understand how management science tools can guide managerial decision making, the second essay investigates this location decision… Advisors/Committee Members: Modi, Sachin (Committee Co-Chair), Rachamadugu, Ram (Committee Co-Chair).

Subjects/Keywords: Business Administration; Pharmaceuticals; Operations Research; Systems Design; Systems Science; Supply Chain, Disintermediation, Biopharmaceutical, Personalized Medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Ben Jebara, M. (2015). Essays on Biopharmaceutical Supply Chains. (Doctoral Dissertation). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1438776838

Chicago Manual of Style (16th Edition):

Ben Jebara, Marouen. “Essays on Biopharmaceutical Supply Chains.” 2015. Doctoral Dissertation, University of Toledo. Accessed March 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1438776838.

MLA Handbook (7th Edition):

Ben Jebara, Marouen. “Essays on Biopharmaceutical Supply Chains.” 2015. Web. 21 Mar 2019.

Vancouver:

Ben Jebara M. Essays on Biopharmaceutical Supply Chains. [Internet] [Doctoral dissertation]. University of Toledo; 2015. [cited 2019 Mar 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1438776838.

Council of Science Editors:

Ben Jebara M. Essays on Biopharmaceutical Supply Chains. [Doctoral Dissertation]. University of Toledo; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1438776838

2. Huang, Chenglei. Developing Circular Economy Capability: Antecedents, Mechanisms, and Outcomes in Chinese Manufacturing Industry.

Degree: PhD, College of Business and Innovation, 2012, University of Toledo

In today’s age of industrialization and globalization, environmental deterioration and overuse of natural resources are identified as bottlenecks of social and economic development worldwide. To address these issues, a circular economy has been used by China as its national environmental strategy. The circular economy emphasizes 1) reducing resource and energy use, 2) reusing materials and items, and 3) recycling wastes and used products. Practically, China implements a circular economy at three different levels: regions, industrial parks, and companies. While adequate research has been done at the regional and industrial-park levels, how companies participate in a circular economy is not well understood. To fill this research gap, this study examines the following research questions: 1) What are the mechanisms that enable companies to develop their circular economy capability? 2) What are the antecedents of these mechanisms? 3) Does the development of circular economy capability lead to improvements of environmental and business performances? To address these questions, this research presents a conceptual framework based on complexity theory, natural resource based view (NRBV), dynamic capability theory, absorptive capacity theory, and ecological modernization theory. In particular, product stewardship and green supply chain design are proposed as the key mechanisms through which companies build their circular economy capability. External contextual dynamism for environmental implementation, potential absorptive capacity, and environmental orientation are proposed as antecedents of these mechanisms. Companies’ environmental and business performances are proposed as the outcomes of their circular economy capability. To test this research model, measurement instruments were developed and validated for eight major constructs and 28 sub-constructs. Then, the research model was tested using Structural Equation Modeling (SEM) based on data collected from a large-scale survey of 293 Chinese manufacturing companies. This research makes valuable contributions. Theoretically, this research proposes and tests a model that investigates circular economy implementation; develops valid and reliable measurement instruments; and provides a conceptual foundation for future research. Practically, this research can help companies, especially the Chinese manufacturers improve their environmental operations and eventually achieve a synergy between environmental and business performances. Advisors/Committee Members: Modi, Sachin (Committee Co-Chair), Vonderembse, Mark (Committee Co-Chair).

Subjects/Keywords: Organization Theory; Circular Economy; Environmental Competency; Green Supply Chain Design; Product Stewardship; Sustainable Development

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Huang, C. (2012). Developing Circular Economy Capability: Antecedents, Mechanisms, and Outcomes in Chinese Manufacturing Industry. (Doctoral Dissertation). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1326778525

Chicago Manual of Style (16th Edition):

Huang, Chenglei. “Developing Circular Economy Capability: Antecedents, Mechanisms, and Outcomes in Chinese Manufacturing Industry.” 2012. Doctoral Dissertation, University of Toledo. Accessed March 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1326778525.

MLA Handbook (7th Edition):

Huang, Chenglei. “Developing Circular Economy Capability: Antecedents, Mechanisms, and Outcomes in Chinese Manufacturing Industry.” 2012. Web. 21 Mar 2019.

Vancouver:

Huang C. Developing Circular Economy Capability: Antecedents, Mechanisms, and Outcomes in Chinese Manufacturing Industry. [Internet] [Doctoral dissertation]. University of Toledo; 2012. [cited 2019 Mar 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1326778525.

Council of Science Editors:

Huang C. Developing Circular Economy Capability: Antecedents, Mechanisms, and Outcomes in Chinese Manufacturing Industry. [Doctoral Dissertation]. University of Toledo; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1326778525

3. Yang, Ma Ga. Developing a Focal Firm’s Sustainable Supply Chain Framework: Drivers, Orientation, Practices and Performance Outcomes.

Degree: PhD, Manufacturing and Technology Management, 2013, University of Toledo

As global pressures to address climate change intensify, the costs of natural resources increase, public health and safety concerns grow, and diverse consumption patterns emerge, sustainability has become critical for competing in international markets (Epstein, 2008; Lubin and Esty, 2010; Wu and Pagell, 2011). The goal of sustainability is grounded in the concept of the triple bottom line, which indicates that balancing objectives related to profits, the planet, and people is essential for corporations as they grow and compete in the global economy (Kleindorfer et al., 2005). Taking advantage of a broad and systemic approach to addressing sustainability issues, researchers increasingly acknowledge that linking sustainability with the supply chain is a crucial step for operations management (Hall, 2000; Zhu and Sarkis, 2004; Koplin et al., 2007; Matos and Hall, 2007). Despite a growing number of studies on sustainability from the point of view of the supply chain (Linton et al., 2007; Carter and Rogers, 2009; Pagell and Wu, 2009; Pullman et al., 2009), few researchers have developed an empirically based integrative research framework grounded in relevant theories. In particular, the literature lacks research that empirically examines the nomological network of sustainable supply chain encompassing drivers, strategy, practices, and performance outcomes with consideration for all three dimensions of sustainability (economic, environmental, and social performance) (Elkington, 1994, 1997; Kleindorfer et al., 2005; Seuring and Muller, 2008). Drawing from the theoretical lenses of institutional theory (DiMaggio and Powell, 1983), strategic choice theory (Child, 1972), strategic orientation (Venkatraman, 1989), and the resource-based view of firms (Barney, 1991), this dissertation presents a framework, by taking a holistic view, of a sustainable supply chain aimed at explaining the relationships between the antecedents, strategic orientation, supply chain practices, and performance outcomes. To develop reliable and valid instruments, this study conducted vigorous research methods, including pretest, structural interview, and pilot study (n=34). The hypothesized relationships in the proposed model are tested using structural equation modeling (SEM) from a large-scale survey of 212 U.S. manufacturing firms. Adopting Anderson and Gerbing’s (1988) two-step approach, this study first tested confirmatory factor analysis (CFA) measurement model to establish validity and reliability of the scales. Next, the structural relationships were tested. Overall, 10 out of 15 hypotheses are supported, indicating that the proposed model may need to be revised. To find alternative significant paths, revised structural model with additional paths is conducted. The empirical findings suggest that (1) external pressures (EPs) not only have a direct effect on firms’ strategic sustainability orientation (SSO), but also have an indirect effect on it through top leadership culture (TLC) for sustainability, (2) higher… Advisors/Committee Members: Vonderembse, Mark (Committee Co-Chair), Modi, Sachin (Committee Co-Chair).

Subjects/Keywords: Alternative Energy; Environmental Management; Environmental Studies; Sustainability; sustainability; sustainable operations; sustainable supply chain; U.S. manufacturing firms; empirical study; structural equation modeling; SEM; corporate social responsibility; environmental management; lean manufacturing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Yang, M. G. (2013). Developing a Focal Firm’s Sustainable Supply Chain Framework: Drivers, Orientation, Practices and Performance Outcomes. (Doctoral Dissertation). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1356543598

Chicago Manual of Style (16th Edition):

Yang, Ma Ga. “Developing a Focal Firm’s Sustainable Supply Chain Framework: Drivers, Orientation, Practices and Performance Outcomes.” 2013. Doctoral Dissertation, University of Toledo. Accessed March 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1356543598.

MLA Handbook (7th Edition):

Yang, Ma Ga. “Developing a Focal Firm’s Sustainable Supply Chain Framework: Drivers, Orientation, Practices and Performance Outcomes.” 2013. Web. 21 Mar 2019.

Vancouver:

Yang MG. Developing a Focal Firm’s Sustainable Supply Chain Framework: Drivers, Orientation, Practices and Performance Outcomes. [Internet] [Doctoral dissertation]. University of Toledo; 2013. [cited 2019 Mar 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1356543598.

Council of Science Editors:

Yang MG. Developing a Focal Firm’s Sustainable Supply Chain Framework: Drivers, Orientation, Practices and Performance Outcomes. [Doctoral Dissertation]. University of Toledo; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1356543598

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