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You searched for +publisher:"University of Texas – Austin" +contributor:("McConville, Jason Thomas"). Showing records 1 – 2 of 2 total matches.

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University of Texas – Austin

1. Carvalho, Thiago Cardoso. Development of an inhalational formulation of Coenzyme Q₁₀ to treat lung malignancies.

Degree: PhD, Pharmacy, 2011, University of Texas – Austin

Cancer is the second leading cause of death in the United States and its onset is highly incident in the lungs, with very low long-term survival rates. Chemotherapy plays a significant role for lung cancer treatment, and pulmonary delivery may be a potential route for anticancer drug delivery to treat lung tumors. Coenzyme Q₁₀ (CoQ₁₀) is a poorly-water soluble compound that is being investigated for the treatment of carcinomas. In this work, we hypothesize that formulations of CoQ10 may be developed for pulmonary delivery with a satisfactory pharmacokinetic profile that will have the potential to improve a pharmacodynamic response when treating lung malignancies. The formulation design was to use a vibrating-mesh nebulizer to aerosolize aqueous dispersions of CoQ₁₀ stabilized by phospholipids physiologically found in the lungs. In the first study, a method was developed to measure the surface tension of liquids, a physicochemical property that has been shown to influence the aerosol output characteristics from vibrating-mesh nebulizers. Subsequently, this method was used, together with analysis of particle size distribution, zeta potential, and rheology, to further evaluate the factors influencing the capability of this nebulizer system to continuously and steadily aerosolize formulations of CoQ₁₀ prepared with high pressure homogenization. The aerosolization profile (nebulization performance and in vitro drug deposition of nebulized droplets) of formulations prepared with soybean lecithin, dimyristoylphosphatidylcholine (DMPC), dipalmitoylphosphatidylcholine (DPPC) and distearoylphosphatidylcholine (DSPC) were evaluated. The rheological behavior of these dispersions was found to be the factor that may be indicative of the aerosolization output profile. Finally, the pulmonary deposition and systemic distribution of CoQ₁₀ prepared as DMPC, DPPC, and DSPC dispersions were investigated in vivo in mice. It was found that high drug amounts were deposited and retained in the mouse lungs for at least 48 hours post nebulization. Systemic distribution was not observed and deposition in the nasal cavity occurred at a lower scale than in the lungs. This body of work provides evidence that CoQ₁₀ may be successfully formulated as dispersions to be aerosolized using vibrating-mesh nebulizers and achieve high drug deposition in the lungs during inhalation. Advisors/Committee Members: McConville, Jason Thomas (advisor).

Subjects/Keywords: Formulation; Inhalation; Lung cancer; Chemotherapy; Coenzyme Q₁₀; Ubiquinone; Ubidecarenone; Nebulization; Colloidal dispersions; Phospholipids; High pressure homogenization; Microfluidization; Rheology; Surface tension; Particle size; Zeta potential; Maximum pull on a disk; Aerodynamic deposition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Carvalho, T. C. (2011). Development of an inhalational formulation of Coenzyme Q₁₀ to treat lung malignancies. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/21556

Chicago Manual of Style (16th Edition):

Carvalho, Thiago Cardoso. “Development of an inhalational formulation of Coenzyme Q₁₀ to treat lung malignancies.” 2011. Doctoral Dissertation, University of Texas – Austin. Accessed September 25, 2020. http://hdl.handle.net/2152/21556.

MLA Handbook (7th Edition):

Carvalho, Thiago Cardoso. “Development of an inhalational formulation of Coenzyme Q₁₀ to treat lung malignancies.” 2011. Web. 25 Sep 2020.

Vancouver:

Carvalho TC. Development of an inhalational formulation of Coenzyme Q₁₀ to treat lung malignancies. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2011. [cited 2020 Sep 25]. Available from: http://hdl.handle.net/2152/21556.

Council of Science Editors:

Carvalho TC. Development of an inhalational formulation of Coenzyme Q₁₀ to treat lung malignancies. [Doctoral Dissertation]. University of Texas – Austin; 2011. Available from: http://hdl.handle.net/2152/21556


University of Texas – Austin

2. Morales, Javier Octavio. Mucoadhesive films for the buccal delivery of insulin.

Degree: PhD, Pharmacy, 2012, University of Texas – Austin

To address the need of a patient friendly and therapeutically effective method of administration of insulin (Ins) we sought to develop mucoadhesive films for delivery through the buccal mucosa. Ins is a labile molecule exhibiting limited activity and stability in solid solutions in films and other solid delivery devices. Early investigations outlined in Chapter 3 revealed the need for a certain particle size (below the one micrometer) for the addition of particulate material in films. In Chapter 4 a novel method for the manufacture of protein-coated nanoparticles (PCNP) is depicted. Successful particle batches were achieved in terms of size, uniformity, stability and activity and these particles were further investigated for their inclusion on films for buccal delivery. The method of manufacture of particles was based on an antisolvent co-precipitation process that immobilized macromolecules to the surface of crystalline core particles resulting in high yields and highly active protein loaded particles. Films loaded with PCNP were developed and characterized in Chapter 5. Lysozyme was utilized as a model macromolecule and high yields and activity were obtained after manufacture, demonstrating that after all the processing the protein is subjected to, activity is preserved. Using Eudragit® RLPO (ERL) as the matrix forming polymer, films with excellent mucoadhesion were developed. Here is described a high mucoadhesion for ERL that was even further increased by the addition of the water soluble PCNP. This occurred by the water movement into the ERL matrix that the solubilizing particles generate. Finally, films containing Ins were developed and assayed for permeation through buccal mucosa. By adapting the method of manufacture, Ins-coated nanoparticles were obtained and embedded in films. ERL films corroborated previous findings by exhibiting excellent performance. Investigations on the permeation of Ins through buccal mucosa revealed that the inclusion of Ins in films enhanced its permeation in comparison with a control Ins solution. Thus here is described the successful development of mucoadhesive films for the buccal delivery of Ins. Advisors/Committee Members: Williams, Robert O., 1956- (advisor), McConville, Jason Thomas (advisor), Smyth, Hugh D (committee member), Cui, Zhengrong (committee member), Roy, Krishnendu (committee member).

Subjects/Keywords: Buccal delivery; Insulin; Eudragit; Nanoparticle; Enzyme activity; Films

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Morales, J. O. (2012). Mucoadhesive films for the buccal delivery of insulin. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/41763

Chicago Manual of Style (16th Edition):

Morales, Javier Octavio. “Mucoadhesive films for the buccal delivery of insulin.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed September 25, 2020. http://hdl.handle.net/2152/41763.

MLA Handbook (7th Edition):

Morales, Javier Octavio. “Mucoadhesive films for the buccal delivery of insulin.” 2012. Web. 25 Sep 2020.

Vancouver:

Morales JO. Mucoadhesive films for the buccal delivery of insulin. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2020 Sep 25]. Available from: http://hdl.handle.net/2152/41763.

Council of Science Editors:

Morales JO. Mucoadhesive films for the buccal delivery of insulin. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/41763

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