+publisher:"University of Texas – Austin" +contributor:("Emelianov, Stanislav")

University of Texas – Austin

1. Luke, Geoffrey Patrick. Functional and molecular photoacoustic imaging for the detection of lymph node metastasis.

Degree: PhD, Electrical and Computer Engineering, 2013, University of Texas – Austin

► Accurate detection of the spread of cancer is critical for planning the best treatment strategy for a patient. Currently, an invasive sentinel lymph node biopsy… (more)

Subjects/Keywords: Photoacoustic imaging; Molecular imaging; Sentinel lymph node; Ultrasound imaging; Nanoparticles; Image processing; Spectroscopy

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APA (6^th Edition):

Luke, G. P. (2013). Functional and molecular photoacoustic imaging for the detection of lymph node metastasis. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/28713

Chicago Manual of Style (16^th Edition):

Luke, Geoffrey Patrick. “Functional and molecular photoacoustic imaging for the detection of lymph node metastasis.” 2013. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/28713.

MLA Handbook (7^th Edition):

Luke, Geoffrey Patrick. “Functional and molecular photoacoustic imaging for the detection of lymph node metastasis.” 2013. Web. 19 Jan 2021.

Vancouver:

Luke GP. Functional and molecular photoacoustic imaging for the detection of lymph node metastasis. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/28713.

Council of Science Editors:

Luke GP. Functional and molecular photoacoustic imaging for the detection of lymph node metastasis. [Doctoral Dissertation]. University of Texas – Austin; 2013. Available from: http://hdl.handle.net/2152/28713

University of Texas – Austin

2. -2455-7116. Optically-triggered nanodroplets for enhanced ultrasound and photoacoustic imaging.

Degree: PhD, Biomedical Engineering, 2015, University of Texas – Austin

URL: http://hdl.handle.net/2152/30343

► Medical ultrasound imaging is ubiquitous in clinics due to its safety, low cost, portability, and imaging depth. The development of technologies to assist ultrasound in… (more)

Subjects/Keywords: Ultrasound; Imaging; Contrast agents; Perfluorocarbon

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APA (6^th Edition):

-2455-7116. (2015). Optically-triggered nanodroplets for enhanced ultrasound and photoacoustic imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/30343

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-2455-7116. “Optically-triggered nanodroplets for enhanced ultrasound and photoacoustic imaging.” 2015. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/30343.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-2455-7116. “Optically-triggered nanodroplets for enhanced ultrasound and photoacoustic imaging.” 2015. Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-2455-7116. Optically-triggered nanodroplets for enhanced ultrasound and photoacoustic imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/30343.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-2455-7116. Optically-triggered nanodroplets for enhanced ultrasound and photoacoustic imaging. [Doctoral Dissertation]. University of Texas – Austin; 2015. Available from: http://hdl.handle.net/2152/30343

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Texas – Austin

3. Dumani Jarquin, Diego Sayed. Photoacoustic imaging for temperature monitoring and photothermal therapy guidance.

Degree: MSin Engineering, Biomedical engineering, 2015, University of Texas – Austin

URL: http://hdl.handle.net/2152/31748

► Cancer is among the leading causes of death in the United States and the world. Using combined ultrasound (US) and photoacoustic (PA) imaging can provide… (more)

Subjects/Keywords: Ultrasound; Photoacoustic; Imaging; Nanoparticles; Contrast agents; Photothermal therapy; Cancer

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APA (6^th Edition):

Dumani Jarquin, D. S. (2015). Photoacoustic imaging for temperature monitoring and photothermal therapy guidance. (Masters Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/31748

Chicago Manual of Style (16^th Edition):

Dumani Jarquin, Diego Sayed. “Photoacoustic imaging for temperature monitoring and photothermal therapy guidance.” 2015. Masters Thesis, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/31748.

MLA Handbook (7^th Edition):

Dumani Jarquin, Diego Sayed. “Photoacoustic imaging for temperature monitoring and photothermal therapy guidance.” 2015. Web. 19 Jan 2021.

Vancouver:

Dumani Jarquin DS. Photoacoustic imaging for temperature monitoring and photothermal therapy guidance. [Internet] [Masters thesis]. University of Texas – Austin; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/31748.

Council of Science Editors:

Dumani Jarquin DS. Photoacoustic imaging for temperature monitoring and photothermal therapy guidance. [Masters Thesis]. University of Texas – Austin; 2015. Available from: http://hdl.handle.net/2152/31748

4. Park, Suhyun, 1977-. Integrated system for ultrasonic, elasticity and photoacoustic imaging.

Degree: PhD, Biomedical Engineering, 2008, University of Texas – Austin

URL: http://hdl.handle.net/2152/17894

► By integrating three complementary imaging techniques - ultrasound, elasticity and photoacoustic imaging, a hybrid imaging system utilizing an array transducer is proposed for various biomedical… (more)

▼ By integrating three complementary imaging techniques - ultrasound, elasticity and photoacoustic imaging, a hybrid imaging system utilizing an array transducer is proposed for various biomedical imaging applications including cancer detection, diagnosis and therapy monitoring. Simultaneous imaging of the anatomy (ultrasound imaging), changes in biomechanical properties (elasticity imaging) and cancer-induced angiogenesis (photoacoustic imaging) of tissue is based on many synergistic features of these modalities and may result in a unique and important imaging tool. In this study, numerical analysis and experimental studies are presented to demonstrate the feasibility, to evaluate the performance, and also to improve the quality of the combined array-based ultrasound, elasticity and photoacoustic imaging system. To estimate spatial resolution, a point source was imaged using ultrasound and photoacoustic imaging modes. Then, several tissue mimicking phantoms were examined using ultrasound, photoacoustic and elasticity imaging. In elasticity imaging, ultrasound frames were acquired during deformation of the tissue. To reduce the data acquisition time of the system, high frame rate imaging was used. High frame rate imaging is possible by transmitting a broader and less focused ultrasound beam but the image quality is sacrificed. Thus, we compared the quality of the high frame rate and conventional ultrasound images. In photoacoustic imaging, acoustic transients are generated simultaneously in the entire volume of the laser irradiated tissue. Hence, image formation (beamforming) algorithms were developed based on the characteristics of the photoacoustic signals. Then, adaptive beamforming method is suggested to improve the image quality of the photoacoustic imaging. The results of the numerical analyses and experimental studies clearly indicate that ultrasound, elasticity and photoacoustic imaging techniques complement each other and together provide critical information needed for the reliable detection and diagnosis of diseases. Advisors/Committee Members: Emelianov, Stanislav Y. (advisor).

Subjects/Keywords: Ultrasonic imaging; Elasticity; Tissues – Imaging; Diagnostic imaging; Optoacoustic spectroscopy

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APA (6^th Edition):

Park, Suhyun, 1. (2008). Integrated system for ultrasonic, elasticity and photoacoustic imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/17894

Chicago Manual of Style (16^th Edition):

Park, Suhyun, 1977-. “Integrated system for ultrasonic, elasticity and photoacoustic imaging.” 2008. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/17894.

MLA Handbook (7^th Edition):

Park, Suhyun, 1977-. “Integrated system for ultrasonic, elasticity and photoacoustic imaging.” 2008. Web. 19 Jan 2021.

Vancouver:

Park, Suhyun 1. Integrated system for ultrasonic, elasticity and photoacoustic imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2008. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/17894.

Council of Science Editors:

Park, Suhyun 1. Integrated system for ultrasonic, elasticity and photoacoustic imaging. [Doctoral Dissertation]. University of Texas – Austin; 2008. Available from: http://hdl.handle.net/2152/17894

5. Shah, Jignesh Mukesh, 1979-. Ultrasound and photoacoustic imaging to guide and monitor photothermal therapy.

Degree: PhD, Biomedical Engineering, 2008, University of Texas – Austin

URL: http://hdl.handle.net/2152/18123

► Photothermal cancer therapy is a potential alternative to surgery and involves selective tissue destruction using thermal energy. Targeted photoabsorbers, used in conjunction with matching a… (more)

Subjects/Keywords: Acoustic imaging; Imaging systems in medicine; Diagnostic ultrasonic imaging; Cancer – Treatment; Photothermal spectroscopy

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APA (6^th Edition):

Shah, Jignesh Mukesh, 1. (2008). Ultrasound and photoacoustic imaging to guide and monitor photothermal therapy. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/18123

Chicago Manual of Style (16^th Edition):

Shah, Jignesh Mukesh, 1979-. “Ultrasound and photoacoustic imaging to guide and monitor photothermal therapy.” 2008. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/18123.

MLA Handbook (7^th Edition):

Shah, Jignesh Mukesh, 1979-. “Ultrasound and photoacoustic imaging to guide and monitor photothermal therapy.” 2008. Web. 19 Jan 2021.

Vancouver:

Shah, Jignesh Mukesh 1. Ultrasound and photoacoustic imaging to guide and monitor photothermal therapy. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2008. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/18123.

Council of Science Editors:

Shah, Jignesh Mukesh 1. Ultrasound and photoacoustic imaging to guide and monitor photothermal therapy. [Doctoral Dissertation]. University of Texas – Austin; 2008. Available from: http://hdl.handle.net/2152/18123

6. Mallidi, Srivalleesha. Molecular specific photoacoustic imaging using plasmonic gold nanoparticles.

Degree: PhD, Biomedical Engineering, 2009, University of Texas – Austin

URL: http://hdl.handle.net/2152/18152

► Cancer has become one of the leading causes of death today. The early detection of cancer may lead to desired therapeutic management of cancer and… (more)

Subjects/Keywords: Gold nanoparticles; Optical contrast agents; Cancer cells; Epidermal growth factor receptor; Plasmon resonances; Photoacoustic imaging

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APA (6^th Edition):

Mallidi, S. (2009). Molecular specific photoacoustic imaging using plasmonic gold nanoparticles. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/18152

Chicago Manual of Style (16^th Edition):

Mallidi, Srivalleesha. “Molecular specific photoacoustic imaging using plasmonic gold nanoparticles.” 2009. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/18152.

MLA Handbook (7^th Edition):

Mallidi, Srivalleesha. “Molecular specific photoacoustic imaging using plasmonic gold nanoparticles.” 2009. Web. 19 Jan 2021.

Vancouver:

Mallidi S. Molecular specific photoacoustic imaging using plasmonic gold nanoparticles. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2009. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/18152.

Council of Science Editors:

Mallidi S. Molecular specific photoacoustic imaging using plasmonic gold nanoparticles. [Doctoral Dissertation]. University of Texas – Austin; 2009. Available from: http://hdl.handle.net/2152/18152

7. Chen, Yun-Sheng, active 2012. Contrast and sensitivity enhanced molecular imaging using photoacoustic nanoamplifiers.

Degree: PhD, Electrical and Computer Engineering, 2012, University of Texas – Austin

URL: http://hdl.handle.net/2152/22125

► Molecular imaging is an emerging imaging principle which can visually represent the biological processes both spatially and temporally down to the sub-cellular level in vivo.… (more)

▼ Molecular imaging is an emerging imaging principle which can visually represent the biological processes both spatially and temporally down to the sub-cellular level in vivo. The outcome of this research is expected to have a profound impact on facilitating the early diagnosis of diseases, accelerating the development of new drugs, and improving the efficacy of therapy. In general, molecular imaging highly relies on probes to sense the occurrence of molecular biological events, and to generate signals which could be picked up by diagnostic imaging modalities. The advances in the design of molecular probes not only have equipped traditional anatomical medical imaging with new capabilities but also, in some cases, stimulated developments of new imaging modalities and renaissance of existing medical imaging modalities. One of these is photoacoustic imaging, which as an emerging medical imaging modality, unites the merits from both optical imaging and ultrasound imaging. It shares with optical imaging, that it uses non-ionizing radiation and provides higher contrast and higher sensitivity than ultrasound imaging. Unlike optical imaging, which requires ballistic photons for imaging, photoacoustic imaging requires only diffusive photons to excite the ultrasound signal from the imaging target; therefore, it is capable of imaging much deeper into the tissue. In combination with molecular probes, photoacoustic molecular imaging has been demonstrated by several research groups using various photoacoustic molecular probes. However, the molecular probes used for most of these studies were contrast agents simply adopted from other optical imaging modalities. Our research on photoacoustic contrast agents indicated that the mechanism of photoacoustic signal generation from nanometer-sized contrast agents is distinct from that of optically homogeneous materials, such as tissue. We have discovered that, the amplitude of the photoacoustic signal generated from nano-contrast agents depends not only on the optical absorption of the particles, but more importantly, on the dynamic process of the heat conduction from the nanoparticles to the ambient, and the thermal properties of the surrounding materials. Based on our finding, we explored and further improved the photoacoustic response of the nanoparticles by exploiting the heat conduction process between the nanoparticle and its surrounding materials and by manipulating the excitations. This research allows to create optimized molecular specific contrast enhanced photothermal stable probes which can aid photoacoustic imaging and image guided photothermal cancer therapy. Advisors/Committee Members: Emelianov, Stanislav Y. (advisor).

Subjects/Keywords: Photoacoustic imaging; Photothermal cancer therapy; Molecular probes; Contrast agents; Bioconjugation; Nanoparticles

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APA (6^th Edition):

Chen, Yun-Sheng, a. 2. (2012). Contrast and sensitivity enhanced molecular imaging using photoacoustic nanoamplifiers. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/22125

Chicago Manual of Style (16^th Edition):

Chen, Yun-Sheng, active 2012. “Contrast and sensitivity enhanced molecular imaging using photoacoustic nanoamplifiers.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/22125.

MLA Handbook (7^th Edition):

Chen, Yun-Sheng, active 2012. “Contrast and sensitivity enhanced molecular imaging using photoacoustic nanoamplifiers.” 2012. Web. 19 Jan 2021.

Vancouver:

Chen, Yun-Sheng a2. Contrast and sensitivity enhanced molecular imaging using photoacoustic nanoamplifiers. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/22125.

Council of Science Editors:

Chen, Yun-Sheng a2. Contrast and sensitivity enhanced molecular imaging using photoacoustic nanoamplifiers. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/22125

8. Mehrmohammadi, Mohammad. Pulsed magneto-motive ultrasound imaging.

Degree: PhD, Biomedical Engineering, 2012, University of Texas – Austin

URL: http://hdl.handle.net/2152/22236

► Nano-sized particles are widely regarded as a tool to study biological events at cellular and molecular levels. However, there are only a few imaging modalities… (more)

Subjects/Keywords: Superparamagnetic nanoparticles; Magneto-motive; Ultrasound imaging; Molecular imaging; In-vivo imaging; Xenograft tumor

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APA (6^th Edition):

Mehrmohammadi, M. (2012). Pulsed magneto-motive ultrasound imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/22236

Chicago Manual of Style (16^th Edition):

Mehrmohammadi, Mohammad. “Pulsed magneto-motive ultrasound imaging.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/22236.

MLA Handbook (7^th Edition):

Mehrmohammadi, Mohammad. “Pulsed magneto-motive ultrasound imaging.” 2012. Web. 19 Jan 2021.

Vancouver:

Mehrmohammadi M. Pulsed magneto-motive ultrasound imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/22236.

Council of Science Editors:

Mehrmohammadi M. Pulsed magneto-motive ultrasound imaging. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/22236

University of Texas – Austin

9. Wu, Chun-Hsien, active 21st century. Magneto-plasmonic nanoparticle platform for detection of rare cells and cell therapy.

Degree: PhD, Biomedical Engineering, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/31285

► Magnetic and plasmonic properties combined in a single nanostructure provide a synergy that is advantageous in a number of biomedical applications, such as contrast enhancement… (more)

▼ Magnetic and plasmonic properties combined in a single nanostructure provide a synergy that is advantageous in a number of biomedical applications, such as contrast enhancement in multimodal imaging, simultaneous capture and detection of circulating tumor cells, and photothermal therapy of cancer. These applications have stimulated significant interest in development of magneto-plasmonic nanoparticles with optical absorbance in the near-infrared region and a strong magnetic moment. In this dissertation, we addressed this need to create a novel immunotargeted magneto-plasmonic nanoparticle platform. The nanostructures were synthetized by self-assembly of primary 6 nm iron oxide core-gold shell particles, resulting in densely packed spherical nanoclusters. The close proximity of the primary particles in the nanoclusters generates a greatly improved response to an external magnetic field and strong near-infrared plasmon resonances. A procedure for antibody conjugation and PEGylation to the hybrid nanoparticles was developed for biomedical applications which require molecular and biocompatible targeting. Furthermore, we presented two biomedical applications based on the immunotargeted hybrid nanoparticle platform, including circulating tumor cell (CTC) detection and cell-based immunotherapy of cancer. In the CTC detection assays, rare cancer cells were specifically targeted by antibody-conjugated nanoparticles and efficiently separated from normal blood cells by a magnetic force in a microfluidic chamber. The experiments in whole blood showed capture efficiency greater than 90% for a variety of cancers. We also explored photoacoustic imaging to detect nanoparticle-labeled CTCs in whole blood. The results showed excellent sensitivity to delineate the distribution of hybrid nanoparticles on the cancer cells. Thus, these works paves the way for a novel CTC detection approach which utilizes immunotargeted magneto-plasmonic nanoclusters for a simultaneous magnetic capture and photoacoustic detection of CTCs. In another application, we introduced a novel approach to label cytotoxic T cells using the magnetic nanoparticles with an expectation to enhance T cell recruitment in tumor under external magnetic stimulus. A series of in vitro experiments demonstrated highly controllable manipulation of labeled T cells. Thus, these results highlight the promise of using our nanoparticle platform as a multifunctional probe to manipulate and track immune cells in vivo and further improve the efficacy of cell-based cancer immunotherapy. Advisors/Committee Members: Sokolov, Konstantin V. (Associate professor) (advisor), Dunn, Andrew (committee member), Emelianov, Stanislav (committee member), Yeh, Hsin-Chih (committee member), Zal, Tomasz (committee member).

Subjects/Keywords: Nanoparticle; Gold; Iron oxide; Tumor cell; Adoptive cell therapy

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APA (6^th Edition):

Wu, Chun-Hsien, a. 2. c. (2014). Magneto-plasmonic nanoparticle platform for detection of rare cells and cell therapy. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/31285

Chicago Manual of Style (16^th Edition):

Wu, Chun-Hsien, active 21st century. “Magneto-plasmonic nanoparticle platform for detection of rare cells and cell therapy.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/31285.

MLA Handbook (7^th Edition):

Wu, Chun-Hsien, active 21st century. “Magneto-plasmonic nanoparticle platform for detection of rare cells and cell therapy.” 2014. Web. 19 Jan 2021.

Vancouver:

Wu, Chun-Hsien a2c. Magneto-plasmonic nanoparticle platform for detection of rare cells and cell therapy. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/31285.

Council of Science Editors:

Wu, Chun-Hsien a2c. Magneto-plasmonic nanoparticle platform for detection of rare cells and cell therapy. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/31285

University of Texas – Austin

10. Yeager, Douglas Edward. Intravascular photoacoustics as a theranostic platform for atherosclerosis.

Degree: PhD, Biomedical Engineering, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/31286

► The persistence of high global mortality rates directly attributable to cardiovascular disease drives ongoing research into novel approaches for improved diagnosis and treatment of its… (more)

▼ The persistence of high global mortality rates directly attributable to cardiovascular disease drives ongoing research into novel approaches for improved diagnosis and treatment of its primary underlying cause, atherosclerosis. Combined intravascular ultrasound and photoacoustic (IVUS/IVPA) imaging is one such modality, actively being developed as a tool for improved characterization of high-risk atherosclerotic plaques. The pathophysiology associated with progression and destabilization of atherosclerotic plaques leads to characteristic changes in arterial morphology and composition. IVUS/IVPA imaging seeks to expand upon the ability of clinically utilized intravascular ultrasound (IVUS) imaging to assess vessel anatomy by adding improved sensitivity to image the underlying cellular and molecular composition through intravascular photoacoustic (IVPA) imaging of either endogenous chromophores (e.g. lipid) or exogenously delivered contrast agents. This dissertation focuses on the expansion of IVUS/IVPA imaging using exogenous contrast agents to enable the detection and subsequent optically-triggered therapy of atherosclerotic plaques. The passive extravasation and aggregation of systemically injected plasmonic gold nanorods absorbing within the near infrared tissue optical window within plaques of atherosclerotic rabbit models is first demonstrated, along with the ability to localize the contrast agents using ex vivo IVUS/IVPA imaging. The motivation for nanoparticle labeling of atherosclerosis is then expanded from that of purely image contrast agents to vehicles for image-guided, dual-modality phototherapy. The integrated IVUS/IVPA imaging catheter is utilized for photothermal delivery with simultaneous IVPA temperature monitoring using the high optical absorption of gold nanorod contrast agents to enable localized heating. Subsequently, the potential role for IVUS/IVPA-guided phototherapy is further expanded through the characterization and in vitro assessment of novel multifunctional theranostic nanoparticles comprised of a gold nanorod core with a degradable, photosensitizer-doped silica shell. Together, the results presented within this dissertation provide a framework for ongoing research into the expansion of IVUS/IVPA imaging as a platform for complimentary diagnosis and local treatment of atherosclerotic plaques using multifunctional theranostic nanoparticle contrast agents. Advisors/Committee Members: Emelianov, Stanislav Y. (advisor), Baker, Aaron (committee member), Sessler, Jonathan (committee member), Smalling, Richard (committee member), Sokolov, Konstantin (committee member).

Subjects/Keywords: Intravascular imaging; Atherosclerosis; Ultrasound; Photoacoustic; Gold nanorod; Photothermal therapy; Photodynamic therapy; Theranostic

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APA (6^th Edition):

Yeager, D. E. (2014). Intravascular photoacoustics as a theranostic platform for atherosclerosis. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/31286

Chicago Manual of Style (16^th Edition):

Yeager, Douglas Edward. “Intravascular photoacoustics as a theranostic platform for atherosclerosis.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/31286.

MLA Handbook (7^th Edition):

Yeager, Douglas Edward. “Intravascular photoacoustics as a theranostic platform for atherosclerosis.” 2014. Web. 19 Jan 2021.

Vancouver:

Yeager DE. Intravascular photoacoustics as a theranostic platform for atherosclerosis. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/31286.

Council of Science Editors:

Yeager DE. Intravascular photoacoustics as a theranostic platform for atherosclerosis. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/31286

University of Texas – Austin

11. Ricles, Laura Michelle. Investigating mesenchymal stem cell therapy for ischemic repair.

Degree: PhD, Biomedical Engineering, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/44380

► Cardiovascular diseases are the leading cause of death globally and continue to be a growing health concern. The currently available therapies are not suitable or… (more)

Subjects/Keywords: Cardiovascular disease; Ischemia; Mesenchymal stem cells; Nanoparticles

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APA (6^th Edition):

Ricles, L. M. (2014). Investigating mesenchymal stem cell therapy for ischemic repair. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/44380

Chicago Manual of Style (16^th Edition):

Ricles, Laura Michelle. “Investigating mesenchymal stem cell therapy for ischemic repair.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/44380.

MLA Handbook (7^th Edition):

Ricles, Laura Michelle. “Investigating mesenchymal stem cell therapy for ischemic repair.” 2014. Web. 19 Jan 2021.

Vancouver:

Ricles LM. Investigating mesenchymal stem cell therapy for ischemic repair. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/44380.

Council of Science Editors:

Ricles LM. Investigating mesenchymal stem cell therapy for ischemic repair. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/44380

University of Texas – Austin

12. Wilson, Katheryne Elizabeth. Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets.

Degree: PhD, Biomedical Engineering, 2012, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2012-05-5386

► The recent increase in survival rates of most cancers is due to early detection greatly aided by medical imaging modalities. Combined ultrasound and photoacoustic imaging… (more)

Subjects/Keywords: Ultrasound imaging; Photoacoustic imaging; Contrast agent; Perfluorocarbon; Droplets; Nanoparticles; Dual modality

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APA (6^th Edition):

Wilson, K. E. (2012). Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2012-05-5386

Chicago Manual of Style (16^th Edition):

Wilson, Katheryne Elizabeth. “Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2012-05-5386.

MLA Handbook (7^th Edition):

Wilson, Katheryne Elizabeth. “Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets.” 2012. Web. 19 Jan 2021.

Vancouver:

Wilson KE. Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-5386.

Council of Science Editors:

Wilson KE. Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-5386

University of Texas – Austin

13. Nam, Seung Yun. Ultrasound and photoacoustic imaging to monitor stem cells for tissue regeneration.

Degree: PhD, Electrical and Computer Engineering, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/30945

► Regenerative medicine is an interdisciplinary field which has advanced with the use of biotechnologies related to biomaterials, growth factors, and stem cells to replace or… (more)

▼ Regenerative medicine is an interdisciplinary field which has advanced with the use of biotechnologies related to biomaterials, growth factors, and stem cells to replace or restore damaged cells, tissues, and organs. Among various therapeutic approaches, cell-based therapy is most challenging and exciting for both scientists and clinicians pursuing regenerative medicine. Specifically, stem cells, including mesenchymal stem cells and adipose-derived stem cells, are promising candidate cell types for cell-based therapy because they can differentiate into multiple cell types for tissue regeneration and stimulate other cells through neovascularization or paracrine signaling. Also, for effective treatment using stem cells, the tissue engineered constructs, such as bioactive degradable scaffolds, that provide the physical and chemical cues to guide their differentiation are incorporated with stem cells before implantation. Also, it was previously demonstrated that tissue-engineered matrices can promote tubulogenesis and differentiation of stem cells to vascular cell phenotypes. Hence, during tissue regeneration after stem cell therapy, there are numerous factors that need to be monitored. As a result, imaging-based stem cell tracking is essential to evaluate the distribution of stem cells as well as to monitor proliferation, differentiation, and interaction with the microenvironment. Therefore, there is a need for a stem cell imaging technique that is not only noninvasive, sensitive, and easy to operate, but also capable of quantitatively assessing stem cell behaviors in the long term with high spatial resolution. Therefore, the overall goal of this research is to demonstrate a novel imaging method capable of continuous in vitro assessment of stem cells as prepared with tissue engineered constructs and noninvasive longitudinal in vivo monitoring of stem cell behaviors and tissue regeneration after stem cell implantation. In order to accomplish this, gold nanoparticles are demonstrated as photoacoustic imaging contrasts to label stem cells. In addition, ultrasound and photoacoustic imaging was utilized to monitor stem cells and neovascularization in the injured rat tissue. Therefore, using these methods, tissue regeneration can be promoted and noninvasively monitored, resulting in a better understanding of the tissue repair mechanisms following tissue injury. Advisors/Committee Members: Emelianov, Stanislav Y. (advisor), Suggs, Laura J (committee member), Pearce, John A (committee member), Dunn, Andrew K (committee member), Hall, Neal A (committee member).

Subjects/Keywords: Photoacoustic imaging; Ultrasound imaging; Stem cell; Tissue engineering; Tissue regeneration

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APA (6^th Edition):

Nam, S. Y. (2014). Ultrasound and photoacoustic imaging to monitor stem cells for tissue regeneration. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/30945

Chicago Manual of Style (16^th Edition):

Nam, Seung Yun. “Ultrasound and photoacoustic imaging to monitor stem cells for tissue regeneration.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/30945.

MLA Handbook (7^th Edition):

Nam, Seung Yun. “Ultrasound and photoacoustic imaging to monitor stem cells for tissue regeneration.” 2014. Web. 19 Jan 2021.

Vancouver:

Nam SY. Ultrasound and photoacoustic imaging to monitor stem cells for tissue regeneration. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/30945.

Council of Science Editors:

Nam SY. Ultrasound and photoacoustic imaging to monitor stem cells for tissue regeneration. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/30945

University of Texas – Austin

14. -0656-3800. Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow.

Degree: PhD, Biomedical Engineering, 2016, University of Texas – Austin

URL: http://hdl.handle.net/2152/63850

► Ensuring adequate blood flow during surgical procedures is crucial, as prolonged ischemia can result in tissue death and lead to poor clinical outcomes. This is… (more)

▼ Ensuring adequate blood flow during surgical procedures is crucial, as prolonged ischemia can result in tissue death and lead to poor clinical outcomes. This is especially important during neurosurgery, since the brain relies on a constant supply of cerebral blood flow (CBF) to maintain normal function. Intraoperative blood flow monitoring tools are essential to detect ischemia in a timely manner, and allow surgical correction before the onset of irreversible brain injury. Laser speckle contrast imaging (LSCI) is an optical imaging method that provides blood flow maps with high spatiotemporal resolution, and overcomes many of the limitations of current intraoperative monitoring technologies. The objective of this dissertation is to demonstrate that LSCI is an effective tool for blood flow monitoring during neurosurgery, and to optimize and improve LSCI technology for clinical use. This research has two primary elements: assessing the LSCI instrumentation components in a controlled laboratory setting, and evaluating the clinical performance of LSCI during neurosurgery. The laboratory study aims to determine the optimal specifications for the clinical instrument design, using controlled static and microfluidic flow experiments. Two of the main components of the LSCI instrument are the camera used for recording, and the laser used for coherent illumination of the tissue. Thus, a broad camera and laser comparison was performed spanning a wide array of available hardware options to determine which specifications are the most important for reliable and highly sensitive flow measurements. The two-phase clinical study aims to demonstrate the performance and utility of LSCI in a neurosurgical setting as a potential tool for real-time, continuous, and noninvasive image guidance. These studies demonstrate that LSCI can produce blood flow maps consistent with expected physiological trends, and show the impact of instrument design and image acquisition techniques on image quality and quantitative flow assessment. The results from both the laboratory and clinical studies can be used to design a more sensitive and robust LSCI system, which increases its value as an intraoperative tool for monitoring blood flow. LSCI has the potential to be the next generation of neurosurgical image guidance for blood flow visualization, and the work presented in this dissertation can accelerate its clinical adoption. Advisors/Committee Members: Dunn, Andrew Kenneth, 1970- (advisor), Fox, Jr., Douglas J (committee member), Rylander, III, Henry G (committee member), Tunnell, James W (committee member), Emelianov, Stanislav Y (committee member).

Subjects/Keywords: Laser speckle contrast imaging; Cerebral blood flow; Intraoperative imaging

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APA (6^th Edition):

-0656-3800. (2016). Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/63850

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-0656-3800. “Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow.” 2016. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/63850.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-0656-3800. “Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow.” 2016. Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-0656-3800. Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/63850.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-0656-3800. Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow. [Doctoral Dissertation]. University of Texas – Austin; 2016. Available from: http://hdl.handle.net/2152/63850

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Texas – Austin

15. Wang, Bo, 1981-. Characterization of atherosclerotic plaques using ultrasound guided intravascular photoacoustic imaging.

Degree: PhD, Biomedical Engineering, 2011, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2011-05-3454

► Rupture of atherosclerotic plaque is closely related to plaque composition. Currently, plaque composition cannot be clinically characterized by any imaging modality. The objective of this… (more)

Subjects/Keywords: Intravascular photoacoustic imaging; Atherosclerosis; Tissue characterization; Intravascular ultrasound; Molecular imaging; Gold nanoparticles; Lipid; Macrophages

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APA (6^th Edition):

Wang, Bo, 1. (2011). Characterization of atherosclerotic plaques using ultrasound guided intravascular photoacoustic imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2011-05-3454

Chicago Manual of Style (16^th Edition):

Wang, Bo, 1981-. “Characterization of atherosclerotic plaques using ultrasound guided intravascular photoacoustic imaging.” 2011. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2011-05-3454.

MLA Handbook (7^th Edition):

Wang, Bo, 1981-. “Characterization of atherosclerotic plaques using ultrasound guided intravascular photoacoustic imaging.” 2011. Web. 19 Jan 2021.

Vancouver:

Wang, Bo 1. Characterization of atherosclerotic plaques using ultrasound guided intravascular photoacoustic imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2011-05-3454.

Council of Science Editors:

Wang, Bo 1. Characterization of atherosclerotic plaques using ultrasound guided intravascular photoacoustic imaging. [Doctoral Dissertation]. University of Texas – Austin; 2011. Available from: http://hdl.handle.net/2152/ETD-UT-2011-05-3454

16. Cook, Jason Ray. Photoacoustic microscopy of nanoparticles in cells and tissues.

Degree: PhD, Biomedical Engineering, 2013, University of Texas – Austin

URL: http://hdl.handle.net/2152/21882

► Molecular photoacoustic imaging is an exciting new field that promises to visualize molecular indicators of disease. The objective of this dissertation is to progress molecular… (more)

Subjects/Keywords: Photoacoustic imaging; Nanoparticles; Quantitative; Histology; Molecular imaging; Microscopy; Nonlinear

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APA (6^th Edition):

Cook, J. R. (2013). Photoacoustic microscopy of nanoparticles in cells and tissues. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/21882

Chicago Manual of Style (16^th Edition):

Cook, Jason Ray. “Photoacoustic microscopy of nanoparticles in cells and tissues.” 2013. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/21882.

MLA Handbook (7^th Edition):

Cook, Jason Ray. “Photoacoustic microscopy of nanoparticles in cells and tissues.” 2013. Web. 19 Jan 2021.

Vancouver:

Cook JR. Photoacoustic microscopy of nanoparticles in cells and tissues. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/21882.

Council of Science Editors:

Cook JR. Photoacoustic microscopy of nanoparticles in cells and tissues. [Doctoral Dissertation]. University of Texas – Austin; 2013. Available from: http://hdl.handle.net/2152/21882

University of Texas – Austin

17. Sethuraman, Shriram. Combined intravascular ultrasound and photoacoustic imaging.

Degree: PhD, Biomedical Engineering, 2007, University of Texas – Austin

URL: http://hdl.handle.net/2152/3300

► The primary focus of the work was to evaluate the capability of intravascular photoacoustic (IVPA) imaging in combination with intravascular ultrasound (IVUS) to detect and… (more)

Subjects/Keywords: Optoacoustic spectroscopy; Intravascular ultrasonography

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APA (6^th Edition):

Sethuraman, S. (2007). Combined intravascular ultrasound and photoacoustic imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/3300

Chicago Manual of Style (16^th Edition):

Sethuraman, Shriram. “Combined intravascular ultrasound and photoacoustic imaging.” 2007. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/3300.

MLA Handbook (7^th Edition):

Sethuraman, Shriram. “Combined intravascular ultrasound and photoacoustic imaging.” 2007. Web. 19 Jan 2021.

Vancouver:

Sethuraman S. Combined intravascular ultrasound and photoacoustic imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2007. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/3300.

Council of Science Editors:

Sethuraman S. Combined intravascular ultrasound and photoacoustic imaging. [Doctoral Dissertation]. University of Texas – Austin; 2007. Available from: http://hdl.handle.net/2152/3300

18. Yoon, Soon Joon. Photoacoustic imaging using nanoclusters.

Degree: PhD, Electrical and Computer Engineering, 2017, University of Texas – Austin

URL: http://hdl.handle.net/2152/62064

► Advances in novel imaging techniques and molecular probes are now extending the opportunity of visualizing molecular targets of disease. Molecular imaging provides anatomic as well… (more)

▼ Advances in novel imaging techniques and molecular probes are now extending the opportunity of visualizing molecular targets of disease. Molecular imaging provides anatomic as well as functional and pathological information to sense the expression of molecular biological events. In general, molecular imaging aims to target a specific cell type or tissue and visualize biological events in vivo at the molecular or cellular levels through specific probes. Molecular imaging is usually performed in conjunction with probes for specific targets. The objective of this dissertation is to explore molecular imaging by providing highly efficient photoacoustic nanocluster contrast agents to further validate in vivo molecular imaging, improve the therapeutic procedure, and study fundamental photoacoustic signal processes from cluster of nanoparticles. Initially, a photothermal stimuli-responsive photoacoustic nanocluster was designed and synthesized to provide highly sensitive dynamic contrast within tissue samples. The photoacoustic signal enhancement from clustering of nanoparticles was demonstrated by characterizing the photoacoustic signal from photothermal stimuli-responsive nanoclusters. After characterization, photothermal stimuli-responsive nanoclusters were injected into a mouse tissue and the dynamic photoacoustic response from the nanoclusters activated by an external laser source was observed. This activation can be repeatedly turned on by modulating input laser signals, suggesting a new route for dynamic photoacoustic contrast imaging that will further improve the imaging contrast and more accurately guide the drug release process. Despite tremendous advantages of using these nanoparticles, their safety in a biological environment could be a major hurdle for their in vivo utilization. In order to avoid accumulation and long-term toxicity of nanoparticles, biodegradable nanoclusters consisting of sub-5 nm primary gold particles stabilized by a weakly adsorbed biodegradable polymer were introduced. The photoacoustic signal from biodegradable nanoclusters was quantitatively characterized. In addition, photothermal stability of different sizes of biodegradable nanoclusters was investigated. These nanoclusters were then intravenously injected into mice and biodistribution of nanoparticles was observed. Finally, in vivo spectroscopic photoacoustic imaging was performed on tumor-bearing mice with antibody conjugated biodegradable nanoclusters. This research may provide a new opportunity for molecular imaging to help diagnose tumors at an early stage and promote clinical translation of these techniques. Advisors/Committee Members: Emelianov, Stanislav Y. (advisor), Sokolov, Konstantin (committee member), Johnston, Keith (committee member), Pearce, John (committee member), Yu, Edward (committee member).

Subjects/Keywords: Photoacoustic; Nanoparticles; Nanoclusters; Photothermal; Biodegradable

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APA (6^th Edition):

Yoon, S. J. (2017). Photoacoustic imaging using nanoclusters. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/62064

Chicago Manual of Style (16^th Edition):

Yoon, Soon Joon. “Photoacoustic imaging using nanoclusters.” 2017. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/62064.

MLA Handbook (7^th Edition):

Yoon, Soon Joon. “Photoacoustic imaging using nanoclusters.” 2017. Web. 19 Jan 2021.

Vancouver:

Yoon SJ. Photoacoustic imaging using nanoclusters. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2017. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/62064.

Council of Science Editors:

Yoon SJ. Photoacoustic imaging using nanoclusters. [Doctoral Dissertation]. University of Texas – Austin; 2017. Available from: http://hdl.handle.net/2152/62064

19. Dana, Nicholas Pacheco. Photoacoustic image guidance and tissue characterization in cardiovascular applications.

Degree: PhD, Biomedical engineering, 2016, University of Texas – Austin

URL: http://hdl.handle.net/2152/46211

► Collectively, cardiovascular diseases continue to be the leading cause of death, across nations and across decades. Improved diagnostic imaging methods offer promise to alleviate the… (more)

▼ Collectively, cardiovascular diseases continue to be the leading cause of death, across nations and across decades. Improved diagnostic imaging methods offer promise to alleviate the morbidity associated with these diseases. Photoacoustic (PA) imaging is one such method, poised to make a significant impact on cardiovascular imaging, both as a research tool, as well as a clinical imaging modality. Offering the potential of molecular imaging in real-time, PA methods have been demonstrated in proof-of-concept studies tracking myocyte calcium dynamics. These results open the door to non-invasive longitudinal assessment of cardiac electrophysiological function, with implications for drug and contrast agent development. PA image guidance has also been extended to the characterization of cardiac radiofrequency ablation lesions. This method has been demonstrated to utilize endogenous chromophore changes resulting from ablation for the generation of depth-resolved tissue characterization maps, capable of assessing lesion extent. The technique has been subsequently validated by assessing high-intensity focused ultrasound ablation lesions in myocardium, with the hope for offering thermographic capabilities as well. While PA imaging offers such promise in cardiac ablation procedures, it is also in the process of clinical translation for image guidance and characterization in coronary artery disease applications. Research has shown, using Monte Carlo optical modeling, that using a simple dual-wavelength PA imaging technique has great potential for successful visualization of atherosclerotic plaques across multiple tissue types and at clinically relevant multiple millimeters of depth. Collectively these results offer a suite of PA imaging tools with the potential for molecular and thermographic imaging across a broad range of cardiovascular applications. Advisors/Committee Members: Suggs, Laura J. (advisor), Emelianov, Stanislav Y. (advisor), Dunn, Andrew (committee member), Tunnell, James (committee member), Bouchard, Richard (committee member).

Subjects/Keywords: Photoacoustic; Cardiovascular; Imaging; Arrhythmia; Ablation; Atherosclerosis; Coronary; Monte Carlo

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APA (6^th Edition):

Dana, N. P. (2016). Photoacoustic image guidance and tissue characterization in cardiovascular applications. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/46211

Chicago Manual of Style (16^th Edition):

Dana, Nicholas Pacheco. “Photoacoustic image guidance and tissue characterization in cardiovascular applications.” 2016. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/46211.

MLA Handbook (7^th Edition):

Dana, Nicholas Pacheco. “Photoacoustic image guidance and tissue characterization in cardiovascular applications.” 2016. Web. 19 Jan 2021.

Vancouver:

Dana NP. Photoacoustic image guidance and tissue characterization in cardiovascular applications. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/46211.

Council of Science Editors:

Dana NP. Photoacoustic image guidance and tissue characterization in cardiovascular applications. [Doctoral Dissertation]. University of Texas – Austin; 2016. Available from: http://hdl.handle.net/2152/46211

20. Su, Jimmy Li-Shin. Clinical photoacoustic imaging for detection and characterization of metal implants.

Degree: PhD, Biomedical Engineering, 2011, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2011-08-3919

► Accurate insertion and monitoring of metal implants in-vivo is essential for clinical diagnosis and therapy of various diseases. Clinical studies and examples have demonstrated that… (more)

▼ Accurate insertion and monitoring of metal implants in-vivo is essential for clinical diagnosis and therapy of various diseases. Clinical studies and examples have demonstrated that the misplacement errors of these metal devices can have dramatic consequences. This thesis focuses on three main metal devices that are in widespread use today: needles, coronary stents and brachytherapy seeds. Each application requires proper image-guidance for correct usage. For needles, image guidance is required to ensure correct local injection delivery or needle aspiration biopsy. Fine needle aspiration biopsies are performed in order to avoid major surgical excisions when obtaining tissue biopsy procedures. However, because of the small biopsy sample, the risk is that the sample is collected outside of the tumorigenic region, resulting in a false negative result. Implantation of stents requires that confirmation that proper stent apposition has been achieved due to balloon inflation. Furthermore, it is important to guide the stent to shield the vulnerable region of an atherosclerotic plaque. With prostate brachytherapy seeds, the ability to monitor seed placement is crucial because needle deflections or tissue deformation can result in seed misplacement errors, decreasing the efficacy of the pre-established treatment plan. For the described applications and other possible clinical practices involving the use of metallic implants, an imaging technology that can accurately depict the location of the metal objects, relative to their respective backgrounds, in real-time, is necessary to improve the safety and the efficacy of these procedures. Currently, ultrasound is used because of its real-time capabilities, non-ionizing radiation, and soft tissue contrast. However, due to high acoustic scattering from tissue, the contrast of metal implants can be low. Photoacoustic imaging can be used as an alternative, or complementary, imaging method to ultrasound for imaging metal. This thesis focuses on the benefits and the pitfalls of using photoacoustic imaging for detecting three different metal implants, each having unique requirements. Overall, the goal of this work is to develop a framework for clinical applications using combined ultrasound and photoacoustic imaging to help guide, detect and follow-up on clinical metal implants introduced in-vivo. Advisors/Committee Members: Emelianov, Stanislav Y. (advisor), Dunn, Andrew (committee member), Karpiouk, Andrei (committee member), Smalling, Richard (committee member), Sokolov, Konstantin (committee member).

Subjects/Keywords: Ultrasound; Photoacoustic; Medical imaging

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APA (6^th Edition):

Su, J. L. (2011). Clinical photoacoustic imaging for detection and characterization of metal implants. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2011-08-3919

Chicago Manual of Style (16^th Edition):

Su, Jimmy Li-Shin. “Clinical photoacoustic imaging for detection and characterization of metal implants.” 2011. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2011-08-3919.

MLA Handbook (7^th Edition):

Su, Jimmy Li-Shin. “Clinical photoacoustic imaging for detection and characterization of metal implants.” 2011. Web. 19 Jan 2021.

Vancouver:

Su JL. Clinical photoacoustic imaging for detection and characterization of metal implants. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2011-08-3919.

Council of Science Editors:

Su JL. Clinical photoacoustic imaging for detection and characterization of metal implants. [Doctoral Dissertation]. University of Texas – Austin; 2011. Available from: http://hdl.handle.net/2152/ETD-UT-2011-08-3919

21. -7772-6051. Applications of ultrasound and photoacoustics in the central nervous system.

Degree: PhD, Biomedical Engineering, 2017, University of Texas – Austin

URL: http://hdl.handle.net/2152/60433

► Ultrasound imaging has seen a new resurgence in both clinical and preclinical research as demand for affordable and accessible imaging techniques has increased. There are… (more)

▼ Ultrasound imaging has seen a new resurgence in both clinical and preclinical research as demand for affordable and accessible imaging techniques has increased. There are both therapeutic and imaging applications of ultrasound. In these studies, the feasibility of several new applications for ultrasound-based imaging techniques are explored. Specifically, a new method for measuring the flow of cerebrospinal fluid (CSF) in cerebral shunt systems of patients with hydrocephalus was investigated. A cross-correlation based speckle-tracking algorithm was used to measure displacement of flowing perfluorocarbon microbubbles in a catheter. This method was able to detect lower flow rates than other CSF flow measurement methods in the literature and could be used for both an initial evaluation of shunt function as well as a tool for studying CSF flow dynamics over time in patients with hydrocephalus. Additionally, the use of focused ultrasound (FUS) blood brain barrier (BBB) disruption for delivery of imaging contrast agents is presented. First, FUS BBB disruption was used to deliver an oxygen-sensitive two-photon contrast agent in the parenchyma of C57BL/6 mice. Both fluorescence and phosphorescence signal from the dye were detectable in the extravascular space after sonication. Then, the delivery of photoacoustic (PA) gold nanorods (AuNRs) via FUS BBB disruption was demonstrated, though further parameter optimization will be necessary. Finally, a possible PA contrast agents for Alzheimer’s Disease was tested. Antibodies for beta-amyloid were conjugated to gold nanoparticles and the conjugated nanoparticles were tested with synthetic peptides and in AD tissue samples. These studies showed that the nanoparticles could specifically bind to synthetic peptides, though electrostatic interactions with the surface the peptides were deposited on complicated interpretation of specificity of the particles. The results of the overall studies indicate that, with the increase in demand for affordable, non-invasive methods for brain imaging and, more broadly, neuroscience, there are numerous potential applications for ultrasound-based techniques. Advisors/Committee Members: Dunn, Andrew Kenneth, 1970- (advisor), Emelianov, Stanislav Y. (advisor), Aglyamov, Salavat (committee member), Tunnell, James (committee member), Xie, Chong (committee member).

Subjects/Keywords: Biomedical imaging; Ultrasound; Photoacoustics; Brain imaging; Blood brain barrier; Focused ultrasound; Alzheimer's; Hydrocephalus; Stroke

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APA (6^th Edition):

-7772-6051. (2017). Applications of ultrasound and photoacoustics in the central nervous system. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/60433

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-7772-6051. “Applications of ultrasound and photoacoustics in the central nervous system.” 2017. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/60433.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-7772-6051. “Applications of ultrasound and photoacoustics in the central nervous system.” 2017. Web. 19 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-7772-6051. Applications of ultrasound and photoacoustics in the central nervous system. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2017. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/60433.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-7772-6051. Applications of ultrasound and photoacoustics in the central nervous system. [Doctoral Dissertation]. University of Texas – Austin; 2017. Available from: http://hdl.handle.net/2152/60433

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

22. Wang, Dan. Real-time 3D visualization of organ deformations based on structured dictionary.

Degree: PhD, Electrical and Computer Engineering, 2012, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2012-05-4996

► Minimally invasive technique (MIS) revolutionized the field of surgery for its shorter hospitalization time, lower complication rates, and ultimately reduced morbidity and mortality. However, one… (more)

▼ Minimally invasive technique (MIS) revolutionized the field of surgery for its shorter hospitalization time, lower complication rates, and ultimately reduced morbidity and mortality. However, one of the critical challenges that prevent it from reaching the full potentials is the restricted visualization from the traditional monocular camera systems at the presence of tissue deformations. This dissertation aims to design a new approach which can provide the surgeons with real time 3D visualization of complete organ deformations during the MIS operation. This new approach even allows the surgeon to see through the wall of an organ rather than just looking at its surface. The proposed design consists of two stages. The first training stage identified the deformation subspaces from a training data set in the transformed spherical harmonic domain, such that each surface can be sparsely represented in the structured dictionary with low dimensionality. This novel idea is based on our experimental discovery that the spherical harmonic coefficients of any organ surface lie in specific low dimensional subspaces. The second reconstruction stage reconstructs the complete deformations in realtime using surface samples obtained with an optical device from a limited field of view while applying the structured dictionary. The sparse surface representation algorithm is also applied to ultrasound image enhancement and efficient surgical simulation. The former is achieved by fusing ultrasound samples 5 with optical data under proper weighting strategies. The high speed of surgical simulation is obtained by decreasing the computational cost based on the high compactness of the surface representation algorithm. In order to verify the proposed approaches, we first use the computer models to demonstrate that the proposed approach matches the accuracy of complex mathematical modeling techniques. Then ex-vivo experiments are conducted on freshly excised porcine kidneys utilizing a 3D MRI machine, a 3D optical device and an ultrasound machine to further test the feasibility under practical settings. Advisors/Committee Members: Tewfik, Ahmed (advisor), Bovik, Alan (committee member), Caramanis, Constantine (committee member), Markey, Mia K. (committee member), Emelianov, Stanislav (committee member), Tunnell, James W. (committee member).

Subjects/Keywords: Organ deformation; Dictionary learning; Sparse representation

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APA (6^th Edition):

Wang, D. (2012). Real-time 3D visualization of organ deformations based on structured dictionary. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2012-05-4996

Chicago Manual of Style (16^th Edition):

Wang, Dan. “Real-time 3D visualization of organ deformations based on structured dictionary.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2012-05-4996.

MLA Handbook (7^th Edition):

Wang, Dan. “Real-time 3D visualization of organ deformations based on structured dictionary.” 2012. Web. 19 Jan 2021.

Vancouver:

Wang D. Real-time 3D visualization of organ deformations based on structured dictionary. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-4996.

Council of Science Editors:

Wang D. Real-time 3D visualization of organ deformations based on structured dictionary. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-4996

23. Qu, Min. Magneto-photo-acoustic imaging.

Degree: PhD, Biomedical Engineering, 2012, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2012-05-5579

► Cancer is a major public health problem worldwide due to its poor prognosis. Detection of cancer in the earliest stages is crucial for the success… (more)

Subjects/Keywords: Magneto-photo-acoustic imaging; Nanoparticle delivery; Nanoparticle endocytosis; Non-invasive imaging

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APA (6^th Edition):

Qu, M. (2012). Magneto-photo-acoustic imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2012-05-5579

Chicago Manual of Style (16^th Edition):

Qu, Min. “Magneto-photo-acoustic imaging.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2012-05-5579.

MLA Handbook (7^th Edition):

Qu, Min. “Magneto-photo-acoustic imaging.” 2012. Web. 19 Jan 2021.

Vancouver:

Qu M. Magneto-photo-acoustic imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-5579.

Council of Science Editors:

Qu M. Magneto-photo-acoustic imaging. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-5579

24. Yoon, Sangpil. Estimation of the mechanical properties of soft tissues using a laser-induced microbubble interrogated by acoustic radiation force.

Degree: PhD, Mechanical Engineering, 2012, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2012-05-5132

► This dissertation introduces a new approach to measure the mechanical properties of soft tissues. A laser-induced microbubble, created by focusing a single nanosecond laser pulse… (more)

▼ This dissertation introduces a new approach to measure the mechanical properties of soft tissues. A laser-induced microbubble, created by focusing a single nanosecond laser pulse with a custom-made objective lens, was created at desired locations inside a tissue sample. An acoustic radiation force was generated by a low frequency transducer to displace the microbubble. A custom-built high pulse repetition frequency (PRF) ultrasound system, consisting of two 25 MHz single element transducers, was used to track the dynamics of the microbubble. Reconstruction of the mechanical properties at the specific location in a tissue sample was performed using a theoretical model, which calculated the dynamics of a microbubble under an externally applied force in a viscoelastic medium. The theoretical model and the high PRF ultrasound system were successfully validated in both gelatin phantoms and ex vivo bovine crystalline lenses. Age-related sclerosis of the crystalline lenses from bovine was clearly detected, which might be linked to changes in the crystalline. Location-dependent variation explained that the outer cortex and the inner nucleus had different mechanical properties. In the old and young porcine vitreous humors, age-related changes were not found. However, local variations of the mechanical properties were discovered, which may coincide with the different distributions of the molecular compositions. The laser-induced microbubble approach shows potential for future research into the origin of physiological phenomena and the development of inherent disorders in the eye. I hope that further studies – in the development of a more suitable theoretical model for the microbubble dynamics, in extension to in vivo applications, and in defining the relationship of the mechanical properties to molecular components in the eye – may provide a plan for the therapeutic treatment of eye-related diseases. Advisors/Committee Members: Emelianov, Stanislav Y. (advisor), Hamilton, Mark F. (committee member), Aglyamov, Salavat R. (committee member), Wilson, Preston S. (committee member), Karpiouk, Andrei B. (committee member), Larin, Kirill (committee member).

Subjects/Keywords: Mechanical properties of soft tissues; Viscoelastic properties; Acoustic radiation force; Laser-induced microbubble; The crystalline lens; The vitreous humor

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APA (6^th Edition):

Yoon, S. (2012). Estimation of the mechanical properties of soft tissues using a laser-induced microbubble interrogated by acoustic radiation force. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2012-05-5132

Chicago Manual of Style (16^th Edition):

Yoon, Sangpil. “Estimation of the mechanical properties of soft tissues using a laser-induced microbubble interrogated by acoustic radiation force.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2012-05-5132.

MLA Handbook (7^th Edition):

Yoon, Sangpil. “Estimation of the mechanical properties of soft tissues using a laser-induced microbubble interrogated by acoustic radiation force.” 2012. Web. 19 Jan 2021.

Vancouver:

Yoon S. Estimation of the mechanical properties of soft tissues using a laser-induced microbubble interrogated by acoustic radiation force. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-5132.

Council of Science Editors:

Yoon S. Estimation of the mechanical properties of soft tissues using a laser-induced microbubble interrogated by acoustic radiation force. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-5132

25. Kim, Seungsoo. Ultrasound and photoacoustic imaging for cancer detection and therapy guidance.

Degree: PhD, Biomedical Engineering, 2011, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2011-08-4024

► Cancer has been one of main causes of human deaths for many years. Early detection of cancer is essential to provide definitive treatment. Among many… (more)

▼ Cancer has been one of main causes of human deaths for many years. Early detection of cancer is essential to provide definitive treatment. Among many cancer treatment methods, nanoparticle-mediated photothermal therapy is considered as one of the promising cancer treatment methods because of its non-invasiveness and cancer-specific therapy. Ultrasound and photoacoustic imaging can be utilized for both cancer detection and photothermal therapy guidance. Ultrasound elasticity imaging can detect cancer using tissue elastic properties. Once cancer is diagnosed, spectroscopic photoacoustic imaging can be used to monitor nanoparticle delivery before photothermal therapy. When nanoparticles are well accumulated at the tumor, ultrasound and photoacoustic-based thermal imaging can be utilized for estimating temperature distribution during photothermal therapy to guide therapeutic procedure. In this dissertation, ultrasound beamforming, elasticity imaging, and spectroscopic photoacoustic imaging methods were developed to improve cancer detection and therapy guidance. Firstly, a display pixel based synthetic aperture focusing method was developed to fundamentally improve ultrasound image qualities. Secondly, an autocorrelation based sub-pixel displacement estimation method was developed to enhance signal-to-noise ratio of elasticity images. The developed elasticity imaging method was utilized to clinically evaluate the feasibility of using ultrasound elasticity imaging for prostate cancer detection. Lastly, a minimum mean square error based spectral separation method was developed to robustly utilize spectroscopic photoacoustic imaging. The developed spectroscopic photoacoustic imaging method was utilized to demonstrate ultrasound and photoacoustic image-guided photothermal cancer therapy using in-vivo tumor-bearing mouse models. The results of these studies suggest that ultrasound and photoacoustic imaging can assist both cancer detection and therapy guidance. Advisors/Committee Members: Emelianov, Stanislav Y. (advisor), Aglyamov, Salavat R. (committee member), Sokolov, Konstantin V. (committee member), Hamilton, Mark F. (committee member), Pearce, John A. (committee member).

Subjects/Keywords: Ultrasound; Photoacoustic; Spectroscopic photoacoustic imaging; Elasticity imaging; Thermal imaging; Nanoparticle

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APA (6^th Edition):

Kim, S. (2011). Ultrasound and photoacoustic imaging for cancer detection and therapy guidance. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2011-08-4024

Chicago Manual of Style (16^th Edition):

Kim, Seungsoo. “Ultrasound and photoacoustic imaging for cancer detection and therapy guidance.” 2011. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2011-08-4024.

MLA Handbook (7^th Edition):

Kim, Seungsoo. “Ultrasound and photoacoustic imaging for cancer detection and therapy guidance.” 2011. Web. 19 Jan 2021.

Vancouver:

Kim S. Ultrasound and photoacoustic imaging for cancer detection and therapy guidance. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2011-08-4024.

Council of Science Editors:

Kim S. Ultrasound and photoacoustic imaging for cancer detection and therapy guidance. [Doctoral Dissertation]. University of Texas – Austin; 2011. Available from: http://hdl.handle.net/2152/ETD-UT-2011-08-4024

26. Tom, William James. Focusing light within turbid media with virtual aperture culling of the eigenmodes of a resonator.

Degree: PhD, Biomedical Engineering, 2012, University of Texas – Austin

URL: http://hdl.handle.net/2152/19998

► Virtual aperture culling of the eigenmodes of a resonator (VACER) is a technique to focus light within turbid media at arbitrary locations. A seed pulse… (more)

Subjects/Keywords: Biomedical optics; Lasers; Mode competition; Multiple scattering; Phase conjugation; Turbid media

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APA (6^th Edition):

Tom, W. J. (2012). Focusing light within turbid media with virtual aperture culling of the eigenmodes of a resonator. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/19998

Chicago Manual of Style (16^th Edition):

Tom, William James. “Focusing light within turbid media with virtual aperture culling of the eigenmodes of a resonator.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/19998.

MLA Handbook (7^th Edition):

Tom, William James. “Focusing light within turbid media with virtual aperture culling of the eigenmodes of a resonator.” 2012. Web. 19 Jan 2021.

Vancouver:

Tom WJ. Focusing light within turbid media with virtual aperture culling of the eigenmodes of a resonator. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/19998.

Council of Science Editors:

Tom WJ. Focusing light within turbid media with virtual aperture culling of the eigenmodes of a resonator. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/19998

University of Texas – Austin

27. Cook, Jason Ray. RF/microwave absorbing nanoparticles and hyperthermia.

Degree: MSin Engineering, Biomedical Engineering, 2009, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2009-12-399

► The primary purpose of this work was to evaluate the capability of nanoparticles to transform electromagnetic energy at microwave frequencies into therapeutic heating. Targeted nanoparticles,… (more)

Subjects/Keywords: Hyperthermia; Cancer; Ablation; RF; Radiofrequency; Microwave; Nanoparticle; Diathermy; Ultrasound Imaging; Thermoacoustic; Bioheat Transfer; Tissue Damage Models

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APA (6^th Edition):

Cook, J. R. (2009). RF/microwave absorbing nanoparticles and hyperthermia. (Masters Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2009-12-399

Chicago Manual of Style (16^th Edition):

Cook, Jason Ray. “RF/microwave absorbing nanoparticles and hyperthermia.” 2009. Masters Thesis, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2009-12-399.

MLA Handbook (7^th Edition):

Cook, Jason Ray. “RF/microwave absorbing nanoparticles and hyperthermia.” 2009. Web. 19 Jan 2021.

Vancouver:

Cook JR. RF/microwave absorbing nanoparticles and hyperthermia. [Internet] [Masters thesis]. University of Texas – Austin; 2009. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2009-12-399.

Council of Science Editors:

Cook JR. RF/microwave absorbing nanoparticles and hyperthermia. [Masters Thesis]. University of Texas – Austin; 2009. Available from: http://hdl.handle.net/2152/ETD-UT-2009-12-399

University of Texas – Austin

28. Parthasarathy, Ashwin Bharadwaj. Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging.

Degree: PhD, Biomedical Engineering, 2010, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2010-05-996

► Cerebral blood flow (CBF) measures are central to the investigation of ischemic strokes, spreading depressions, functional and neuronal activation. Laser Speckle Contrast Imaging (LSCI) is… (more)

▼ Cerebral blood flow (CBF) measures are central to the investigation of ischemic strokes, spreading depressions, functional and neuronal activation. Laser Speckle Contrast Imaging (LSCI) is an optical imaging technique that has been used to obtain CBF measures in vivo at high spatial and temporal resolutions, by quantifying the localized spatial blurring of backscattered coherent light induced by blood flow. Despite being widely used for biomedical applications, LSCI's critical limitations such as its tendency to underestimate large flow changes and its inability to accurately estimate CBF through a thinned skull have not been overcome. This dissertation presents a new Multi Exposure Speckle Imaging (MESI) technique that combines a new instrument and mathematical model to overcome these limitations. Additionally, in a pilot clinical study, an adapted neurosurgical microscope was used to obtain intra-operative LSCI images of CBF in humans. The MESI instrument accurately estimates experimental constants by imaging backscattered speckles over a wide range of the camera's exposure durations. The MESI mathematical model helps account for light that has scattered from both static and moving particles. In controlled flow experiments using tissue simulating phantoms, the MESI technique was found to estimate large changes in flow accurately and the estimates of flow changes were found to be unaffected by the presence of static particles in these phantoms. In an in vivo experiment in which the middle cerebral artery in mice was occluded to induce ~100% reduction in CBF, not only was the reduction in CBF accurately estimated by the MESI technique but these estimates of CBF changes were found to be unaffected by the presence of a thinned skull. The validity of statistical models used to derive the MESI mathematical model was confirmed using in vivo dynamic light scattering (DLS) measurements of CBF in mice. The MESI technique's potential to estimate absolute values of CBF in vivo was demonstrated by comparing CBF estimates obtained using the MESI technique to DLS measurements. The MESI technique's ability to measure CBF changes quantitatively through a thinned skull makes it particularly useful in chronic and long term studies leading to the development of better, more accurate stroke models. Advisors/Committee Members: Dunn, Andrew Kenneth, 1970- (advisor), Milner, Thomas (committee member), Tunnell, James (committee member), Emelianov, Stanislav (committee member), Fox, Douglas (committee member).

Subjects/Keywords: Laser Speckle Contrast Imaging; Multi Exposure Speckle Imaging; Optical blood flow measurements; LSCI; MESI; Cerebral blood flow; Ischemic stroke; Speckle spectroscopy; Dynamic Light Scattering; Intra-operative imaging

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APA (6^th Edition):

Parthasarathy, A. B. (2010). Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2010-05-996

Chicago Manual of Style (16^th Edition):

Parthasarathy, Ashwin Bharadwaj. “Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging.” 2010. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2010-05-996.

MLA Handbook (7^th Edition):

Parthasarathy, Ashwin Bharadwaj. “Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging.” 2010. Web. 19 Jan 2021.

Vancouver:

Parthasarathy AB. Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2010. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2010-05-996.

Council of Science Editors:

Parthasarathy AB. Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging. [Doctoral Dissertation]. University of Texas – Austin; 2010. Available from: http://hdl.handle.net/2152/ETD-UT-2010-05-996

University of Texas – Austin

29. Gran, Martin Luke. Metal-polymer nanoparticulate systems for externally-controlled delivery.

Degree: PhD, Chemical Engineering, 2010, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2010-12-2494

► Metal-polymer nanocomposites consisting of gold nanorods and temperature-responsive hydrogel nanoparticulates were investigated for use in externally-controlled drug delivery systems. Several different thermo-responsive hydrogels including poly(N-isopropyl… (more)

▼ Metal-polymer nanocomposites consisting of gold nanorods and temperature-responsive hydrogel nanoparticulates were investigated for use in externally-controlled drug delivery systems. Several different thermo-responsive hydrogels including poly(N-isopropyl acrylamide) (PNIPAAm) and poly(N-isopropryl acrylamide-co-acrylic acid) (P(NIPAAm-co-AA)) nanoparticles were synthesized for these nanocomposites using an aqueous dispersion polymerization method. In addition, nanoparticles of interpenetrating polymer networks (IPN) composed of poly(acrylamide) (PAAm) and poly(acrylic acid) (PAA) were synthesized using a water-in-oil emulsion polymerization. Temperature-responsive equilibrium swelling behavior of nanoparticles with varying crosslinking densities was characterized using dynamic light scattering. IPN systems exhibited a positive swelling response upon heating while PNIPAAm and copolymer systems collapsed upon increase in temperature above the transition point. Nanoparticles were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) which demonstrated shape and morphology of polymer particles. Gold-polymer nanocomposites were formed by grafting gold nanorods to the surface of the polymer nanoparticles. Amine-functionalized gold nanorods were coupled to polymers using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysulfosuccinimide (Sulfo-NHS) to activate carboxyl groups on the surface of the polymer nanoparticles. TEM confirmed successful formation of the metal-polymer nanocomposites. Loading and release of a model therapeutic were done to assess the potential use of the polymer component of the nanocomposite for drug delivery. Fluorescein, a model for chemotherapeutics, was loaded into P(NIPAAm-co-AA) polymer nanoparticulates. Loading of the compound was shown to be a function of crosslinking density in the polymer network. Maximum loading was achieved using nanoparticles synthesized with a 10 mol% crosslinker feed ratio with entrapment efficiencies of 80.0 % and loading capacities of 12.0 %. Cytotoxicity studies were performed using a NIH/3T3 mouse fibroblast cell model. Cell viabilities in presence of P(NIPAAm-co-AA) nanoparticles were comparable to (not statistically different than) controls at concentrations up to 4 mg/ml. Similarly, gold-polymer composite concentrations up to 0.5 mg/ml caused limited cell death. Advisors/Committee Members: Peppas, Nicholas A., 1948- (advisor), Paul, Donald R. (committee member), Freeman, Benny D. (committee member), Johnston, Keith P. (committee member), Emelianov, Stanislav (committee member).

Subjects/Keywords: Drug delivery; Hydrogel; Nanoparticle

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APA (6^th Edition):

Gran, M. L. (2010). Metal-polymer nanoparticulate systems for externally-controlled delivery. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2010-12-2494

Chicago Manual of Style (16^th Edition):

Gran, Martin Luke. “Metal-polymer nanoparticulate systems for externally-controlled delivery.” 2010. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2010-12-2494.

MLA Handbook (7^th Edition):

Gran, Martin Luke. “Metal-polymer nanoparticulate systems for externally-controlled delivery.” 2010. Web. 19 Jan 2021.

Vancouver:

Gran ML. Metal-polymer nanoparticulate systems for externally-controlled delivery. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2010. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2010-12-2494.

Council of Science Editors:

Gran ML. Metal-polymer nanoparticulate systems for externally-controlled delivery. [Doctoral Dissertation]. University of Texas – Austin; 2010. Available from: http://hdl.handle.net/2152/ETD-UT-2010-12-2494

University of Texas – Austin

30. Homan, Kimberly Ann. Nanosystems for combined therapy and imaging of pancreatic cancer.

Degree: PhD, Biomedical Engineering, 2010, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2010-12-2261

► Pancreatic cancer remains a major unsolved health problem, with conventional cancer treatments having little impact on disease course. The objective of this thesis is to… (more)

Subjects/Keywords: Nanosystems; Nanoparticles; Photoacoustics; Drug delivery; Chemotherapy; Nanocages; Nanoplates; Pancreatic cancer

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APA (6^th Edition):

Homan, K. A. (2010). Nanosystems for combined therapy and imaging of pancreatic cancer. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2010-12-2261

Chicago Manual of Style (16^th Edition):

Homan, Kimberly Ann. “Nanosystems for combined therapy and imaging of pancreatic cancer.” 2010. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/ETD-UT-2010-12-2261.

MLA Handbook (7^th Edition):

Homan, Kimberly Ann. “Nanosystems for combined therapy and imaging of pancreatic cancer.” 2010. Web. 19 Jan 2021.

Vancouver:

Homan KA. Nanosystems for combined therapy and imaging of pancreatic cancer. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2010. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/ETD-UT-2010-12-2261.

Council of Science Editors:

Homan KA. Nanosystems for combined therapy and imaging of pancreatic cancer. [Doctoral Dissertation]. University of Texas – Austin; 2010. Available from: http://hdl.handle.net/2152/ETD-UT-2010-12-2261

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