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You searched for +publisher:"University of St. Andrews" +contributor:("Miles, Gareth Brian"). Showing records 1 – 3 of 3 total matches.

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University of St. Andrews

1. Acton, David. Regulation of mammalian spinal locomotor networks by glial cells .

Degree: 2017, University of St. Andrews

Networks of interneurons within the spinal cord coordinate the rhythmic activation of muscles during locomotion. These networks are subject to extensive neuromodulation, ensuring appropriate behavioural output. Astrocytes are proposed to detect neuronal activity via Gαq-linked G-protein coupled receptors and to secrete neuromodulators in response. However, there is currently a paucity of evidence that astrocytic information processing of this kind is important in behaviour. Here, it is shown that protease-activated receptor-1 (PAR1), a Gαq-linked receptor, is preferentially expressed by glia in the spinal cords of postnatal mice. During ongoing locomotor-related network activity in isolated spinal cords, PAR1 activation stimulates release of adenosine triphosphate (ATP), which is hydrolysed to adenosine extracellularly. Adenosine then activates A1 receptors to reduce the frequency of locomotor-related bursting recorded from ventral roots. This entails inhibition of D1 dopamine receptors, activation of which enhances burst frequency. The effect of A1 blockade scales with network activity, consistent with activity-dependent production of adenosine by glia. Astrocytes also regulate activity by controlling the availability of D-serine or glycine, both of which act as co-agonists of glutamate at N-methyl-D-aspartate receptors (NMDARs). The importance of NMDAR regulation for locomotor-related activity is demonstrated by blockade of NMDARs, which reduces burst frequency and amplitude. Bath-applied D-serine increases the frequency of locomotor-related bursting but not intense synchronous bursting produced by blockade of inhibitory transmission, implying activity-dependent regulation of co-agonist availability. Depletion of endogenous D-serine increases the frequency of locomotor-related but not synchronous bursting, indicating that D-serine is required at a subset of NMDARs expressed by inhibitory interneurons. Blockade of the astrocytic glycine transporter GlyT1 increases the frequency of locomotor-related activity, but application of glycine has no effect, indicating that GlyT1 regulates glycine at excitatory synapses. These results indicate that glia play an important role in regulating the output of spinal locomotor networks. Advisors/Committee Members: Miles, Gareth Brian (advisor).

Subjects/Keywords: Spinal cord physiology; Locomotion; Central pattern generator; CPG; Motor control; NMDA receptors; Glia; Glial cells; Astrocytes; Neural networks; Gliotransmission; PAR1; Dopamine; Co-agonist; D-serine; Glycine; GlyT1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Acton, D. (2017). Regulation of mammalian spinal locomotor networks by glial cells . (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/10133

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Acton, David. “Regulation of mammalian spinal locomotor networks by glial cells .” 2017. Thesis, University of St. Andrews. Accessed July 10, 2020. http://hdl.handle.net/10023/10133.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Acton, David. “Regulation of mammalian spinal locomotor networks by glial cells .” 2017. Web. 10 Jul 2020.

Vancouver:

Acton D. Regulation of mammalian spinal locomotor networks by glial cells . [Internet] [Thesis]. University of St. Andrews; 2017. [cited 2020 Jul 10]. Available from: http://hdl.handle.net/10023/10133.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Acton D. Regulation of mammalian spinal locomotor networks by glial cells . [Thesis]. University of St. Andrews; 2017. Available from: http://hdl.handle.net/10023/10133

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of St. Andrews

2. Chouhan, Amit Kumar. Investigating the pathophysiology of amyotrophic lateral sclerosis (ALS) using motoneurons and astrocytes derived from induced pluripotent stem cells obtained from ALS patients .

Degree: 2019, University of St. Andrews

Subjects/Keywords: Neurodegeneration; Motor Neurone Disease; Motoneuron Excitability; Human Stem Cells; Non-cell autonomous; Human induced pluripotent stem cell derived astrocytes & motoneurons; Functional maturity of motoneurons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chouhan, A. K. (2019). Investigating the pathophysiology of amyotrophic lateral sclerosis (ALS) using motoneurons and astrocytes derived from induced pluripotent stem cells obtained from ALS patients . (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/18887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Chouhan, Amit Kumar. “Investigating the pathophysiology of amyotrophic lateral sclerosis (ALS) using motoneurons and astrocytes derived from induced pluripotent stem cells obtained from ALS patients .” 2019. Thesis, University of St. Andrews. Accessed July 10, 2020. http://hdl.handle.net/10023/18887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Chouhan, Amit Kumar. “Investigating the pathophysiology of amyotrophic lateral sclerosis (ALS) using motoneurons and astrocytes derived from induced pluripotent stem cells obtained from ALS patients .” 2019. Web. 10 Jul 2020.

Vancouver:

Chouhan AK. Investigating the pathophysiology of amyotrophic lateral sclerosis (ALS) using motoneurons and astrocytes derived from induced pluripotent stem cells obtained from ALS patients . [Internet] [Thesis]. University of St. Andrews; 2019. [cited 2020 Jul 10]. Available from: http://hdl.handle.net/10023/18887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chouhan AK. Investigating the pathophysiology of amyotrophic lateral sclerosis (ALS) using motoneurons and astrocytes derived from induced pluripotent stem cells obtained from ALS patients . [Thesis]. University of St. Andrews; 2019. Available from: http://hdl.handle.net/10023/18887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of St. Andrews

3. Devlin, Anna-Claire. Title redacted .

Degree: 2016, University of St. Andrews

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Devlin, A. (2016). Title redacted . (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/12867

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Devlin, Anna-Claire. “Title redacted .” 2016. Thesis, University of St. Andrews. Accessed July 10, 2020. http://hdl.handle.net/10023/12867.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Devlin, Anna-Claire. “Title redacted .” 2016. Web. 10 Jul 2020.

Vancouver:

Devlin A. Title redacted . [Internet] [Thesis]. University of St. Andrews; 2016. [cited 2020 Jul 10]. Available from: http://hdl.handle.net/10023/12867.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Devlin A. Title redacted . [Thesis]. University of St. Andrews; 2016. Available from: http://hdl.handle.net/10023/12867

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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