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You searched for +publisher:"University of Southern Mississippi" +contributor:("Hao Xu"). Showing records 1 – 2 of 2 total matches.

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University of Southern Mississippi

1. Chen, Qichuan. The Drosophila T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival.

Degree: MS, Biological Sciences, 2014, University of Southern Mississippi

From a genetic and allelic modifier screen, we report that the Drosophila melanogaster T-box transcription factor midline (mid), a homolog to the human TBX20 gene, interacts with dFOXO within the insulin receptor (InR) and the c-Jun-N-terminal kinase (JNK) signaling pathways to regulate interommatidial bristle (IOB) formation. Previous studies have identified mid’s role in cell fate specification of sensory organ precursor cells in conjunction with the Notch-Delta signaling pathway (Das et al., 2013). The Notch, InR, and JNK signaling pathways regulate dFOXO activity under conditions of stress. Thus, we determined the effects of oxidative stress and metabolic stress by exposing mid-RNAi flies to paraquat and starvation conditions, respectively. We found that oxidative stress suppressed the mid-RNAi phenotype while starvation had no significant effect. We next assayed Mid and H15, a paralog of Mid, via Western blot analysis and report that Mid exhibits a nucleocytoplasmic distribution pattern that is altered within the mid-RNAi mutant while H15 was found exclusively within the cytoplasmic fraction. This opens the possibility that Mid and/or H15 may regulate cytoplasmic targets upstream of dFOXO. The evidence suggests that Mid utilizes the InR, JNK, and Notch signaling pathways to regulate cell fate specification, differentiation, and survival during third instar larval development. Advisors/Committee Members: Sandra Leal, Hao Xu, Janis O'Donnell.

Subjects/Keywords: mid; midline; Tbx20; dFOXO; C-Jun-N-terminal kinase; insulin receptor; Developmental Biology

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APA (6th Edition):

Chen, Q. (2014). The Drosophila T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival. (Masters Thesis). University of Southern Mississippi. Retrieved from https://aquila.usm.edu/masters_theses/76

Chicago Manual of Style (16th Edition):

Chen, Qichuan. “The Drosophila T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival.” 2014. Masters Thesis, University of Southern Mississippi. Accessed April 19, 2019. https://aquila.usm.edu/masters_theses/76.

MLA Handbook (7th Edition):

Chen, Qichuan. “The Drosophila T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival.” 2014. Web. 19 Apr 2019.

Vancouver:

Chen Q. The Drosophila T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival. [Internet] [Masters thesis]. University of Southern Mississippi; 2014. [cited 2019 Apr 19]. Available from: https://aquila.usm.edu/masters_theses/76.

Council of Science Editors:

Chen Q. The Drosophila T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival. [Masters Thesis]. University of Southern Mississippi; 2014. Available from: https://aquila.usm.edu/masters_theses/76


University of Southern Mississippi

2. Davis, Krystyn Elizabeth. Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice.

Degree: MS, Biological Sciences, 2016, University of Southern Mississippi

Inflammatory Bowel Diseases (IBD) cause chronic inflammation of the gastrointestinal tract and debilitating symptoms in those suffering from the diseases. After inducing colitis in a mouse model using Dextran Sulfate Sodium (DSS), prebiotics inulin and oligofructose enriched inulin (OEI) were used as treatments to determine their effects on the gut microbial community, physiological healing process, and immune response in the mice after initial inflammation and before subsequent inflammation, or relapse. The treatment with inulin led to an increase in regulatory T cell number, but this increase was not as significant as the increase induced by the OEI. Inulin increased the inflammation in the mouse colon, whereas inflammation was decreased in the colons of the mice treated with OEI. A three percent increase in butyrate producing bacteria, Clostridium cluster XIVa spp., was observed in mice treated with OEI before the relapse period when compared to untreated mice with colitis. The proposed mechanism for how the OEI led to decreased inflammation in the colons of the treated mice was that the introduction of the prebiotic allowed for an increase in butyrate producing Clostridium cluster XIVa spp., which led to a direct increase in butyrate production in the colon. In turn, this butyrate production led to an increase in differentiation of regulatory T cells and an overall reduction of the immune response and inflammation in the mice treated with OEI. This reduction of immune response and inflammation allowed the mice that were treated with OEI to be more resistant to induced relapse. Advisors/Committee Members: Dr. Shiao Wang, Dr. Fengwei Bai, Dr. Hao Xu.

Subjects/Keywords: Inflammatory Bowel Disease; colitis; prebiotics; gut microbiota; regulatory T cells; gut bacteria; Alternative and Complementary Medicine; Bacteria; Digestive, Oral, and Skin Physiology; Digestive System; Digestive System Diseases; Medical Immunology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Davis, K. E. (2016). Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice. (Masters Thesis). University of Southern Mississippi. Retrieved from https://aquila.usm.edu/masters_theses/194

Chicago Manual of Style (16th Edition):

Davis, Krystyn Elizabeth. “Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice.” 2016. Masters Thesis, University of Southern Mississippi. Accessed April 19, 2019. https://aquila.usm.edu/masters_theses/194.

MLA Handbook (7th Edition):

Davis, Krystyn Elizabeth. “Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice.” 2016. Web. 19 Apr 2019.

Vancouver:

Davis KE. Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice. [Internet] [Masters thesis]. University of Southern Mississippi; 2016. [cited 2019 Apr 19]. Available from: https://aquila.usm.edu/masters_theses/194.

Council of Science Editors:

Davis KE. Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice. [Masters Thesis]. University of Southern Mississippi; 2016. Available from: https://aquila.usm.edu/masters_theses/194

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