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You searched for +publisher:"University of Southern California" +contributor:("Jaskoll, Tina T."). One record found.

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University of Southern California

1. Abichaker, George. Cytomegalovirus induced amelogenesis imperfecta.

Degree: MS, Cranio-Facial Biology, 2012, University of Southern California

BACKGROUND: Cytomegalovirus (CMV) is one of the most common causes of major birth defects in humans. Of the approximately 8400 children born each year in the U.S. with CMV-induced birth defects, more than 1/3 of these children exhibit hypoplasia and hypocalcification of tooth enamel. ❧ OBJECTIVE: Our objective was to initiate the investigation of the pathogenesis of CMV-induced tooth defects and examine the effects of CMV infection on progressive tooth differentiation and amelogenesis. ❧ METHODS: Mouse Cap and Bell stage mandibular first molars were infected with mouse CMV (mCMV) in vitro in a chemically-defined organ culture system and analyzed utilizing histological and immunolocalization methodologies. ❧ RESULTS: CMV infection of embryonic mouse mandibular first molars in vitro induces tooth dysmorphogenesis and enamel defects in a developmental stage- and duration-dependent manner. Initial protein localization studies suggest that the pathogenesis is mediated through NF-κB signaling and that there appears to be an unusual interaction between abnormal mesenchymal cells and surrounding matrix. Rescue with acyclovir indicates that mCMV replication is necessary to initiate and sustain progressive tooth dysmorphogenesis. Cap stage- and Early Bell stage-infected molars exhibit enamel agenesis and Bell stage-infected molars exhibit enamel hypoplasia. ❧ CONCLUSIONS: Our results indicate that mCMV-induced changes in signaling pathways severely delays, but does not completely interrupt, tooth morphogenesis. This viral-induced pathology is coincident with stage-dependent changes in Amelx, Enam and Dspp gene expression, distribution of amelogenin, enamelin, C/EBPα and DSP proteins, cell proliferation localization and dedifferentiation of secretory ameloblasts. Our data indicate that specific levels of Amelx and Dspp gene expression define whether mouse CMV induces enamel agenesis or hypoplasia. Importantly, our results demonstrate that this well-defined embryonic mouse organ culture system can be utilized to delineate the molecular mechanism underlying the CMV-induced tooth defects that characterize the amelogenesis imperfecta phenocopy seen in many CMV-infected children. Advisors/Committee Members: Melnick, Michael (Committee Chair), Sameshima, Glenn (Committee Member), Jaskoll, Tina T. (Committee Member).

Subjects/Keywords: cytomegalovirus; cmv; tooth; amelogenesis imperfecta

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APA (6th Edition):

Abichaker, G. (2012). Cytomegalovirus induced amelogenesis imperfecta. (Masters Thesis). University of Southern California. Retrieved from

Chicago Manual of Style (16th Edition):

Abichaker, George. “Cytomegalovirus induced amelogenesis imperfecta.” 2012. Masters Thesis, University of Southern California. Accessed November 13, 2019.

MLA Handbook (7th Edition):

Abichaker, George. “Cytomegalovirus induced amelogenesis imperfecta.” 2012. Web. 13 Nov 2019.


Abichaker G. Cytomegalovirus induced amelogenesis imperfecta. [Internet] [Masters thesis]. University of Southern California; 2012. [cited 2019 Nov 13]. Available from:

Council of Science Editors:

Abichaker G. Cytomegalovirus induced amelogenesis imperfecta. [Masters Thesis]. University of Southern California; 2012. Available from: