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You searched for +publisher:"University of Southern California" +contributor:("Azen, Stanley P.Marjoram, Paul"). One record found.

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University of Southern California

1. He, Lijun. The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population.

Degree: MS, Biostatistics, 2014, University of Southern California

The Latino population is an admixed population. Previous studies indicate the potential role of ethnicity in the risk of AMD. The purpose of this study is to evaluate the effect of population structure on the association between the risk of AMD and Single Nucleotide Polymorphisms (SNPs). ❧ The Los Angeles Latino Eye Study (LALES) is a unique population‐based cohort study designed to explore eye diseases in the Los Angeles Latino population. 1007 Mexican Americans aged 40 years and older, including 490 subjects with AMD and 517 corresponding controls, were selected from the LALES population. DNA was extracted for all subjects using blood cards. Genotyping of these DNA samples was performed using the Illumina HumanOmniExpress BeadChip. Genotypes of 988 HapMap samples and 88 Native American samples were also included in our study as reference groups for ancestry estimation. ❧ The PLINK and R software packages are used for data analysis. Panels with 243 ancestry informative markers, and others with a range of different numbers of randomly selected SNPs, are used to estimate global ancestry. This global ancestry analysis is performed using the software STRUCTURE and EIGENSTRAT. Logistic regression is used to evaluate the effect of the global ancestry estimates on subsequent association testing. The software Haploview is used to demonstrate the results of Genome Wide Association Study (GWAS). Correlation coefficient r² is computed to assess the methods used to estimate the genetic ancestry and the effect of population stratification. ❧ The average genetic ancestry for individuals from the LALES population is around 52.4% European, 43.5% Native American, 3.8% African, and 0.3% Asian. The results from logistic regression and GWAS indicate that there is no effect of population stratification on the relationship between risk of AMD and SNPs. Advisors/Committee Members: Azen, Stanley P.Marjoram, Paul (Committee Chair), Gauderman, William James (Committee Member).

Subjects/Keywords: ancestry analysis; Latino population; AMD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

He, L. (2014). The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225

Chicago Manual of Style (16th Edition):

He, Lijun. “The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population.” 2014. Masters Thesis, University of Southern California. Accessed April 18, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225.

MLA Handbook (7th Edition):

He, Lijun. “The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population.” 2014. Web. 18 Apr 2021.

Vancouver:

He L. The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population. [Internet] [Masters thesis]. University of Southern California; 2014. [cited 2021 Apr 18]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225.

Council of Science Editors:

He L. The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population. [Masters Thesis]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225

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