+publisher:"University of Oklahoma" +contributor:("West, Ann H.")

University of Oklahoma

1. Popova, Lyubov I. IMMUNODOMINANCE OF ANTIGENIC SITE B IN RECENT CIRCULATING H3N2 INFLUENZA VIRUSES.

Degree: PhD, 2012, University of Oklahoma

The understanding of immunodominance of antigenic sites of HA may allow to predict the antigenic drift and design the vaccine ahead to influenza epidemics. Advisors/Committee Members: West, Ann H.||Air, Gillian M. (advisor).

Subjects/Keywords: Influenza; Antigens; Immunogenetics; Immune response

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APA (6^th Edition):

Popova, L. I. (2012). IMMUNODOMINANCE OF ANTIGENIC SITE B IN RECENT CIRCULATING H3N2 INFLUENZA VIRUSES. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/318784

Chicago Manual of Style (16^th Edition):

Popova, Lyubov I. “IMMUNODOMINANCE OF ANTIGENIC SITE B IN RECENT CIRCULATING H3N2 INFLUENZA VIRUSES.” 2012. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/318784.

MLA Handbook (7^th Edition):

Popova, Lyubov I. “IMMUNODOMINANCE OF ANTIGENIC SITE B IN RECENT CIRCULATING H3N2 INFLUENZA VIRUSES.” 2012. Web. 09 Mar 2021.

Vancouver:

Popova LI. IMMUNODOMINANCE OF ANTIGENIC SITE B IN RECENT CIRCULATING H3N2 INFLUENZA VIRUSES. [Internet] [Doctoral dissertation]. University of Oklahoma; 2012. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/318784.

Council of Science Editors:

Popova LI. IMMUNODOMINANCE OF ANTIGENIC SITE B IN RECENT CIRCULATING H3N2 INFLUENZA VIRUSES. [Doctoral Dissertation]. University of Oklahoma; 2012. Available from: http://hdl.handle.net/11244/318784

University of Oklahoma

2. Powell, Samantha M. THE STRUCTURAL CHARACTERIZATION OF THE INTERACTIONS OF MYOGLOBIN, HEMOGLOBIN, C. DIFFICILE NITROREDUCTASE AND CYTOCHROME P450 WITH N-CONTAINING COMPOUNDS.

Degree: PhD, 2019, University of Oklahoma

URL: http://hdl.handle.net/11244/319369

► The overall goal of my work was to probe the structural biology of drug metabolite protein interactions and to correlate this with the negative side… (more)

▼ The overall goal of my work was to probe the structural biology of drug metabolite protein interactions and to correlate this with the negative side effects associated with many prescription drugs. More specifically, the focus was on the interactions of myoglobin (Mb), hemoglobin (Hb), a Clostridioides difficile nitroreductase (NR), and cytochrome P450 BM3-HD with N-containing compounds. Using a combination of spectroscopy and X-ray crystallography, I was able to accomplish this goal. In Chapter 2, the focus was on the formation of heme-nitroso adducts of Mb and Hb generated through oxidative and reductive pathways. While I initially predicted that heme-nitroso adducts would result from the reaction of Mb and Hb with nitro- and hydroxylamine-containing compounds, what actually resulted was the determination of a variety of products in addition to the predicted N-bound nitroso adducts. X-ray crystal structures of these products revealed that some of the compounds evaluated can indeed damage Hb through the formation of hemichromes that can be correlated with early stages of heme loss, which, downstream, may cause anemia. Additionally, we observed, for the first time, that two of the compounds evaluated are capable of S-nitrosating Hb at the betaCys93 residue, an important contributor to the transportation of NO throughout the body. And finally, one of the X-ray crystal structures displays a ligand trapped in a Xe pocket, further demonstrating how large ligands can travel through the pockets within both Mb and Hb to reach the heme active site. The work presented in this chapter thus demonstrates a wide range of products that can result from the reaction of Mb and Hb with nitro- and hydroxylamine-containing compounds. In Chapter 3, the focus was on C. difficile NRs responsible for metabolizing the antibiotic Mtz. Using UV-vis spectroscopy, I confirmed that a putative NR from C. difficile does in fact function as a Type I NR. Additionally, I solved its X-ray crystal structure, one of the first two reported from the hypervirulent C. difficile strain. The X-ray crystal structure also revealed a putative binding site for Mtz. The work in this chapter provides one of the first expression, purification, characterization and crystallization of a NR from the hypervirulent C. difficile strain. The focus of Chapter 4 was on the interaction of cytochrome P450 BM3-HD with RNOs, imidazoles and arylhydrazines. Using spectroscopy, I showed that the interaction of RNOs with P450 BM3-HD result in N-bound products and the extent of product formation was dependent on alkyl group size. Imidazoles were found to bind through their N-atoms in a type II fashion. And finally, arylhydrazines were observed to initially bind in a type II manner, but with exposure to air, they formed sigma-bonded aryl-iron complexes. The work in this chapter elucidates the identity of the products in the reaction of P450 BM3-HD with RNOs, imidazoles and arylhydrazines. Together, the work presented in Chapters 2-4, shows how N-containing compounds and… Advisors/Committee Members: Richter-Addo, George B. (advisor), West, Ann H. (committee member), Bourne, Christina (committee member), Duerfeldt, Adam (committee member), Dunn, Anne K. (committee member).

Subjects/Keywords: structural biology; nitroreductase; cytochrome P450; nitrogen compounds; heme proteins

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APA (6^th Edition):

Powell, S. M. (2019). THE STRUCTURAL CHARACTERIZATION OF THE INTERACTIONS OF MYOGLOBIN, HEMOGLOBIN, C. DIFFICILE NITROREDUCTASE AND CYTOCHROME P450 WITH N-CONTAINING COMPOUNDS. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/319369

Chicago Manual of Style (16^th Edition):

Powell, Samantha M. “THE STRUCTURAL CHARACTERIZATION OF THE INTERACTIONS OF MYOGLOBIN, HEMOGLOBIN, C. DIFFICILE NITROREDUCTASE AND CYTOCHROME P450 WITH N-CONTAINING COMPOUNDS.” 2019. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/319369.

MLA Handbook (7^th Edition):

Powell, Samantha M. “THE STRUCTURAL CHARACTERIZATION OF THE INTERACTIONS OF MYOGLOBIN, HEMOGLOBIN, C. DIFFICILE NITROREDUCTASE AND CYTOCHROME P450 WITH N-CONTAINING COMPOUNDS.” 2019. Web. 09 Mar 2021.

Vancouver:

Powell SM. THE STRUCTURAL CHARACTERIZATION OF THE INTERACTIONS OF MYOGLOBIN, HEMOGLOBIN, C. DIFFICILE NITROREDUCTASE AND CYTOCHROME P450 WITH N-CONTAINING COMPOUNDS. [Internet] [Doctoral dissertation]. University of Oklahoma; 2019. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/319369.

Council of Science Editors:

Powell SM. THE STRUCTURAL CHARACTERIZATION OF THE INTERACTIONS OF MYOGLOBIN, HEMOGLOBIN, C. DIFFICILE NITROREDUCTASE AND CYTOCHROME P450 WITH N-CONTAINING COMPOUNDS. [Doctoral Dissertation]. University of Oklahoma; 2019. Available from: http://hdl.handle.net/11244/319369

University of Oklahoma

3. Severance, Zachary. Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins.

Degree: PhD, 2020, University of Oklahoma

URL: http://hdl.handle.net/11244/325259

► Oxysterol-binding protein (OSBP) and the OSBP-related proteins (ORPs) comprise a family of lipid-binding proteins organized into 6 subfamilies in humans. ORP subfamily 1 consists of… (more)

Subjects/Keywords: Chemistry, Biochemistry.; Biology, Cell.; Biology, Molecular.; Chemistry, Pharmaceutical.

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APA (6^th Edition):

Severance, Z. (2020). Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/325259

Chicago Manual of Style (16^th Edition):

Severance, Zachary. “Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins.” 2020. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/325259.

MLA Handbook (7^th Edition):

Severance, Zachary. “Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins.” 2020. Web. 09 Mar 2021.

Vancouver:

Severance Z. Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins. [Internet] [Doctoral dissertation]. University of Oklahoma; 2020. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/325259.

Council of Science Editors:

Severance Z. Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins. [Doctoral Dissertation]. University of Oklahoma; 2020. Available from: http://hdl.handle.net/11244/325259

University of Oklahoma

4. Guan, Ye. REACTIONS OF NITRIC OXIDE, NITROSOALKANES WITH GROUP 8 & 9 METALLOPORPHYRINS AND HEME PROTEINS.

Degree: PhD, 2015, University of Oklahoma

URL: http://hdl.handle.net/11244/15493

► This dissertation describes the interactions of nitric oxide (NO) and C-nitrosoalkanes (RNO) with group 8 and 9 metalloporphyrins and heme proteins. The goal of this… (more)

Subjects/Keywords: Chemistry; inorganic; biochemistry

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APA (6^th Edition):

Guan, Y. (2015). REACTIONS OF NITRIC OXIDE, NITROSOALKANES WITH GROUP 8 & 9 METALLOPORPHYRINS AND HEME PROTEINS. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/15493

Chicago Manual of Style (16^th Edition):

Guan, Ye. “REACTIONS OF NITRIC OXIDE, NITROSOALKANES WITH GROUP 8 & 9 METALLOPORPHYRINS AND HEME PROTEINS.” 2015. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/15493.

MLA Handbook (7^th Edition):

Guan, Ye. “REACTIONS OF NITRIC OXIDE, NITROSOALKANES WITH GROUP 8 & 9 METALLOPORPHYRINS AND HEME PROTEINS.” 2015. Web. 09 Mar 2021.

Vancouver:

Guan Y. REACTIONS OF NITRIC OXIDE, NITROSOALKANES WITH GROUP 8 & 9 METALLOPORPHYRINS AND HEME PROTEINS. [Internet] [Doctoral dissertation]. University of Oklahoma; 2015. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/15493.

Council of Science Editors:

Guan Y. REACTIONS OF NITRIC OXIDE, NITROSOALKANES WITH GROUP 8 & 9 METALLOPORPHYRINS AND HEME PROTEINS. [Doctoral Dissertation]. University of Oklahoma; 2015. Available from: http://hdl.handle.net/11244/15493

University of Oklahoma

5. Hebdon, Skyler D. Determinants of gene targeting and regulation by response regulators in Clostridioides difficile.

Degree: PhD, 2018, University of Oklahoma

URL: http://hdl.handle.net/11244/316297

► Bacteria use two-component signal transduction systems to sense the conditions of the environment and adapt their behavior to ensure survival. The separate roles of signal… (more)

▼ Bacteria use two-component signal transduction systems to sense the conditions of the environment and adapt their behavior to ensure survival. The separate roles of signal perception and response output are carried out by histidine kinase and response regulator proteins, respectively. Most response regulators alter gene transcription, but it is not yet possible to predict which genes they regulate. The precise prediction of these gene regulatory outputs could enable researchers to predict, and doctors and patients to mitigate, various bacterial behaviors. This dissertation presents the elucidation of the genes and biological functions regulated by two response regulators, RR_1586 and RR_1677, from the hypervirulent human pathogen Clostridioides difficile R20291. The data presented herein supports the conclusion that RR_1586 regulates genes involved in phosphate transport, and further characterization of its activity suggests several mechanisms it uses to regulate those genes. The bacterial one-hybrid assay used in this study to elucidate the gene regulatory targets of RR_1586 could potentially be used to find a generalizable solution to predicting gene targets of all response regulators from genome sequences alone. In the process of optimizing the bacterial one-hybrid assay for such a broadly impactful endeavor, it was found that RR_1677 appears to regulate the processes of protein synthesis and cell wall synthesis. A bioinformatics pipeline was also constructed by combining several existing utilities to analyze and interpret the experimental results. Two additional lines of research are also presented. The first is the adaptation of Fourier-transform infrared spectroscopy to observe response regulator phosphorylation. This method offers an alternative from the more labor-intensive methods currently available. The second is an analysis of the biophysical interactions between a response regulator from Saccharomyces cerevisiae and its binding partner, a histidine-containing phosphotransfer protein. Characterization of this interaction elucidates the physical impetus behind the evolutionary conservation of a specific glycine residue near the active site whose role was previously unknown. Advisors/Committee Members: West, Ann. H (advisor), Richter-Addo, George B. (committee member), Bourne, Christina (committee member), Karr, Elizabeth A. (committee member), Yip, Ivan (committee member).

Subjects/Keywords: Two-component signal transduction; response regulator; DNA binding; regulon; bioinformatics; Clostridioides difficile

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APA (6^th Edition):

Hebdon, S. D. (2018). Determinants of gene targeting and regulation by response regulators in Clostridioides difficile. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/316297

Chicago Manual of Style (16^th Edition):

Hebdon, Skyler D. “Determinants of gene targeting and regulation by response regulators in Clostridioides difficile.” 2018. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/316297.

MLA Handbook (7^th Edition):

Hebdon, Skyler D. “Determinants of gene targeting and regulation by response regulators in Clostridioides difficile.” 2018. Web. 09 Mar 2021.

Vancouver:

Hebdon SD. Determinants of gene targeting and regulation by response regulators in Clostridioides difficile. [Internet] [Doctoral dissertation]. University of Oklahoma; 2018. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/316297.

Council of Science Editors:

Hebdon SD. Determinants of gene targeting and regulation by response regulators in Clostridioides difficile. [Doctoral Dissertation]. University of Oklahoma; 2018. Available from: http://hdl.handle.net/11244/316297

University of Oklahoma

6. Wang, Bing. X-RAY CRYSTAL STRUCTURES AND CHARACTERIZATION OF THE PRODUCTS FROM THE INTERACTIONS OF MYOGLOBIN WITH NITROGEN OXIDES AND ARYLHYDRAZINES, AND NITROREDUCTASE INTERACTIONS WITH ORGANIC NITRO COMPOUNDS.

Degree: PhD, 2016, University of Oklahoma

URL: http://hdl.handle.net/11244/34616

► This thesis describes research into the roles that metalloproteins and non-metalloproteins play in the biological inorganic/organic chemistry of common nitrogen oxides. There are three main… (more)

▼ This thesis describes research into the roles that metalloproteins and non-metalloproteins play in the biological inorganic/organic chemistry of common nitrogen oxides. There are three main chapters on this work: the first details the reactions of wild-type and mutant myoglobins (Mbs) in their interactions with nitrite and nitric oxide (NO), the second deals with these Mbs and their formation of bioorganometallic derivatives when reacted with arylhydrazines, and the third deals with an FMN-dependent nitroreductase enzyme and its reactions with the clinically relevant metronidazole drug. Mutations to the distal pocket in the active site of Mb were made; specifically, ferric-aqua derivatives of the mutants were expressed, purified, crystallized, and their crystal structures solved to 1.78-1.85 Å resolution. The proteins crystallized in either the P21 or P6 space groups. The crystals were soaked with nitrite to form their O-bonded MbIII(ONO) complexes whose structures were also solved to 1.57-1.85 Å resolution. In the case of the H64A distal pocket mutant missing the H-bonding amino-acid residue in the 64th position, a water bridge was observed to form linking the protein exterior with the bound nitrite ligand, thus replacing the expected wt H64 H-bonding feature. Further, we noted that the distal pocket Val68 residue adapted its conformation to accommodate the nitrite ligands in some of these complexes. Notably, the O-binding modes observed in the four wt and mutant structures held up exceedingly well even with the variation in H-bonding capacities. These wt and mutant Mb(ONO) compounds can be reduced with sodium dithionite to their respective nitrosyl Mb(NO) products. Verification of the formation of the nitrosyl Fe-NO derivative, and not the closely related nitroxyl Fe-HNO, was provided by FT-infrared spectroscopy. Arylhydrazines and derivatives are prevalent in nature and in pharmaceutical drugs. They interact with various heme proteins resulting in deactivation of the proteins. Eleven X-ray crystal structures of the products from the reactions of wt and mutant (H64A, H64Q, V68A/I107Y) Mbs with arylhydrazines (ArNHNH2; Ar = Ph, m-tol, and p-chlorophenyl) were obtained to 1.70-1.98 Å resolution. Direct Fe-carbon bonds were observed in all these derivatives, establishing that the hydrazine -NHNH2 moieties had been released from the reagents during their reactions with the Fe centers of the Mbs. Importantly, the C-atoms coordinating to the Fe centers were the same as those that bonded to the hydrazine functional groups, implying that the carbon-based radical intermediates were formed in close proximity to the Fe centers allowing for facile and efficient reactions to give the bioorganometallic Mb-aryl products. Significant distal pocket amino acid movements were observed in some cases with the larger p-chlorophenyl ligand aryl; for example, in the H64Q-chlorophenyl derivative, the Gln64 residue swings to a position outside the pocket towards the solvent region. We report the first expression, purification,… Advisors/Committee Members: Richter-Addo, George B. (advisor), West, Ann H. (committee member), Nicholas, Kenneth M. (committee member), Li, Jun (committee member), Ruyle, Jessica (committee member).

Subjects/Keywords: crystallography; myoglobin; nitrite; nitric oxide; nitroreductase; metronidazole

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APA (6^th Edition):

Wang, B. (2016). X-RAY CRYSTAL STRUCTURES AND CHARACTERIZATION OF THE PRODUCTS FROM THE INTERACTIONS OF MYOGLOBIN WITH NITROGEN OXIDES AND ARYLHYDRAZINES, AND NITROREDUCTASE INTERACTIONS WITH ORGANIC NITRO COMPOUNDS. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/34616

Chicago Manual of Style (16^th Edition):

Wang, Bing. “X-RAY CRYSTAL STRUCTURES AND CHARACTERIZATION OF THE PRODUCTS FROM THE INTERACTIONS OF MYOGLOBIN WITH NITROGEN OXIDES AND ARYLHYDRAZINES, AND NITROREDUCTASE INTERACTIONS WITH ORGANIC NITRO COMPOUNDS.” 2016. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/34616.

MLA Handbook (7^th Edition):

Wang, Bing. “X-RAY CRYSTAL STRUCTURES AND CHARACTERIZATION OF THE PRODUCTS FROM THE INTERACTIONS OF MYOGLOBIN WITH NITROGEN OXIDES AND ARYLHYDRAZINES, AND NITROREDUCTASE INTERACTIONS WITH ORGANIC NITRO COMPOUNDS.” 2016. Web. 09 Mar 2021.

Vancouver:

Wang B. X-RAY CRYSTAL STRUCTURES AND CHARACTERIZATION OF THE PRODUCTS FROM THE INTERACTIONS OF MYOGLOBIN WITH NITROGEN OXIDES AND ARYLHYDRAZINES, AND NITROREDUCTASE INTERACTIONS WITH ORGANIC NITRO COMPOUNDS. [Internet] [Doctoral dissertation]. University of Oklahoma; 2016. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/34616.

Council of Science Editors:

Wang B. X-RAY CRYSTAL STRUCTURES AND CHARACTERIZATION OF THE PRODUCTS FROM THE INTERACTIONS OF MYOGLOBIN WITH NITROGEN OXIDES AND ARYLHYDRAZINES, AND NITROREDUCTASE INTERACTIONS WITH ORGANIC NITRO COMPOUNDS. [Doctoral Dissertation]. University of Oklahoma; 2016. Available from: http://hdl.handle.net/11244/34616

University of Oklahoma

7. Tan, Hui. Functional characterization of the phosphorelay protein MPR1 from Schizosaccharomyces pombe.

Degree: PhD, Department of Chemistry and Biochemistry, 2007, University of Oklahoma

URL: http://hdl.handle.net/11244/1186

► The yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae utilize not only serine/threonine/tyrosine phosphorylation that is dominant in the eukaryotic kingdom, but also employ histidine/aspartate phosphorylation that… (more)

Subjects/Keywords: Cellular signal transduction.; Schizosaccharomyces pombe.; Chemistry, Biochemistry.; Yeast.; Protein-protein interactions.

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APA (6^th Edition):

Tan, H. (2007). Functional characterization of the phosphorelay protein MPR1 from Schizosaccharomyces pombe. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/1186

Chicago Manual of Style (16^th Edition):

Tan, Hui. “Functional characterization of the phosphorelay protein MPR1 from Schizosaccharomyces pombe.” 2007. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/1186.

MLA Handbook (7^th Edition):

Tan, Hui. “Functional characterization of the phosphorelay protein MPR1 from Schizosaccharomyces pombe.” 2007. Web. 09 Mar 2021.

Vancouver:

Tan H. Functional characterization of the phosphorelay protein MPR1 from Schizosaccharomyces pombe. [Internet] [Doctoral dissertation]. University of Oklahoma; 2007. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/1186.

Council of Science Editors:

Tan H. Functional characterization of the phosphorelay protein MPR1 from Schizosaccharomyces pombe. [Doctoral Dissertation]. University of Oklahoma; 2007. Available from: http://hdl.handle.net/11244/1186

University of Oklahoma

8. Porter, Stace Wayne. Identification and analysis of the response regulator binding site on the surface of the histidine-containing phosphotransfer protein YPD1 from Saccharomyces cerevisiae.

Degree: PhD, Department of Chemistry and Biochemistry, 2003, University of Oklahoma

URL: http://hdl.handle.net/11244/661

► In order to identify a response regulator binding site on the surface of YPD1, studies were conducted that coupled alanine-scanning mutagenesis on the surface of… (more)

Subjects/Keywords: Chemistry, Biochemistry.; Saccharomyces cerevisiae.; Phosphotransferases.; Cellular signal transduction.

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APA (6^th Edition):

Porter, S. W. (2003). Identification and analysis of the response regulator binding site on the surface of the histidine-containing phosphotransfer protein YPD1 from Saccharomyces cerevisiae. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/661

Chicago Manual of Style (16^th Edition):

Porter, Stace Wayne. “Identification and analysis of the response regulator binding site on the surface of the histidine-containing phosphotransfer protein YPD1 from Saccharomyces cerevisiae.” 2003. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/661.

MLA Handbook (7^th Edition):

Porter, Stace Wayne. “Identification and analysis of the response regulator binding site on the surface of the histidine-containing phosphotransfer protein YPD1 from Saccharomyces cerevisiae.” 2003. Web. 09 Mar 2021.

Vancouver:

Porter SW. Identification and analysis of the response regulator binding site on the surface of the histidine-containing phosphotransfer protein YPD1 from Saccharomyces cerevisiae. [Internet] [Doctoral dissertation]. University of Oklahoma; 2003. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/661.

Council of Science Editors:

Porter SW. Identification and analysis of the response regulator binding site on the surface of the histidine-containing phosphotransfer protein YPD1 from Saccharomyces cerevisiae. [Doctoral Dissertation]. University of Oklahoma; 2003. Available from: http://hdl.handle.net/11244/661

University of Oklahoma

9. Xu, Qingping. The structure and function of YPD1, a histidine-containing phosphotransfer protein from yeast.

Degree: PhD, Department of Chemistry and Biochemistry, 2001, University of Oklahoma

URL: http://hdl.handle.net/11244/366

► The role of a hydrogen bond between Gln86 and the phosphorylatable His64 was also investigated. Structures of three YPD1 mutants, Q86A, Q86E and Q86L revealed… (more)

Subjects/Keywords: Biology, Molecular.; Proteins.; Chemistry, Biochemistry.; Yeast.; Phosphotransferases.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xu, Q. (2001). The structure and function of YPD1, a histidine-containing phosphotransfer protein from yeast. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/366

Chicago Manual of Style (16^th Edition):

Xu, Qingping. “The structure and function of YPD1, a histidine-containing phosphotransfer protein from yeast.” 2001. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/366.

MLA Handbook (7^th Edition):

Xu, Qingping. “The structure and function of YPD1, a histidine-containing phosphotransfer protein from yeast.” 2001. Web. 09 Mar 2021.

Vancouver:

Xu Q. The structure and function of YPD1, a histidine-containing phosphotransfer protein from yeast. [Internet] [Doctoral dissertation]. University of Oklahoma; 2001. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/366.

Council of Science Editors:

Xu Q. The structure and function of YPD1, a histidine-containing phosphotransfer protein from yeast. [Doctoral Dissertation]. University of Oklahoma; 2001. Available from: http://hdl.handle.net/11244/366

University of Oklahoma

10. Kaserer, Alla Olegivna. Effect of osmolytes on regulating the activities of the SSK1 response regulator from Saccharomyces cerevisiae.

Degree: PhD, 2009, University of Oklahoma

URL: http://hdl.handle.net/11244/319044

► Mutational analysis of the CaSSK1 response regulator domain was also performed. Mutants were expressed, purified and their activity was analyzed using an in vitro phosphorylation… (more)

Subjects/Keywords: Saccharomyces cerevisiae; Phosphotransferases; Cellular signal transduction; Protein kinases

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APA (6^th Edition):

Kaserer, A. O. (2009). Effect of osmolytes on regulating the activities of the SSK1 response regulator from Saccharomyces cerevisiae. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/319044

Chicago Manual of Style (16^th Edition):

Kaserer, Alla Olegivna. “Effect of osmolytes on regulating the activities of the SSK1 response regulator from Saccharomyces cerevisiae.” 2009. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/319044.

MLA Handbook (7^th Edition):

Kaserer, Alla Olegivna. “Effect of osmolytes on regulating the activities of the SSK1 response regulator from Saccharomyces cerevisiae.” 2009. Web. 09 Mar 2021.

Vancouver:

Kaserer AO. Effect of osmolytes on regulating the activities of the SSK1 response regulator from Saccharomyces cerevisiae. [Internet] [Doctoral dissertation]. University of Oklahoma; 2009. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/319044.

Council of Science Editors:

Kaserer AO. Effect of osmolytes on regulating the activities of the SSK1 response regulator from Saccharomyces cerevisiae. [Doctoral Dissertation]. University of Oklahoma; 2009. Available from: http://hdl.handle.net/11244/319044

University of Oklahoma

11. Andi, Babak. Studies on selected enzymes of the alpha-aminoadipate pathway for lysine biosynthesis in Saccharomyces cerevisiae.

Degree: PhD, Department of Chemistry and Biochemistry, 2005, University of Oklahoma

URL: http://hdl.handle.net/11244/944

► Kinetic data have been collected suggesting a preferred sequential ordered kinetic mechanism for the His-tagged HCS from S. cerevisiae with alpha-Kg binding before AcCoA and… (more)

Subjects/Keywords: Saccharomyces cerevisiae.; Biosynthesis.; Lysine Synthesis.; Chemistry, Biochemistry.; Enzymes.; Biophysics, General.

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APA (6^th Edition):

Andi, B. (2005). Studies on selected enzymes of the alpha-aminoadipate pathway for lysine biosynthesis in Saccharomyces cerevisiae. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/944

Chicago Manual of Style (16^th Edition):

Andi, Babak. “Studies on selected enzymes of the alpha-aminoadipate pathway for lysine biosynthesis in Saccharomyces cerevisiae.” 2005. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/944.

MLA Handbook (7^th Edition):

Andi, Babak. “Studies on selected enzymes of the alpha-aminoadipate pathway for lysine biosynthesis in Saccharomyces cerevisiae.” 2005. Web. 09 Mar 2021.

Vancouver:

Andi B. Studies on selected enzymes of the alpha-aminoadipate pathway for lysine biosynthesis in Saccharomyces cerevisiae. [Internet] [Doctoral dissertation]. University of Oklahoma; 2005. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/944.

Council of Science Editors:

Andi B. Studies on selected enzymes of the alpha-aminoadipate pathway for lysine biosynthesis in Saccharomyces cerevisiae. [Doctoral Dissertation]. University of Oklahoma; 2005. Available from: http://hdl.handle.net/11244/944

University of Oklahoma

12. Copeland, Daniel Morris. A study of the interactions of nitric oxide and nitric oxide containing molecules with heme proteins.

Degree: PhD, Department of Chemistry and Biochemistry, 2006, University of Oklahoma

URL: http://hdl.handle.net/11244/1101

► Recently, it has been shown that hemoglobin (Hb) and myoglobin catalyze the reduction of nitrite to NO under hypoxic conditions. Prior to our work, there… (more)

Subjects/Keywords: Hemoproteins.; Nitric oxide.; Myoglobin.; Chemistry, Inorganic.; Chemistry, Biochemistry.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Copeland, D. M. (2006). A study of the interactions of nitric oxide and nitric oxide containing molecules with heme proteins. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/1101

Chicago Manual of Style (16^th Edition):

Copeland, Daniel Morris. “A study of the interactions of nitric oxide and nitric oxide containing molecules with heme proteins.” 2006. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/1101.

MLA Handbook (7^th Edition):

Copeland, Daniel Morris. “A study of the interactions of nitric oxide and nitric oxide containing molecules with heme proteins.” 2006. Web. 09 Mar 2021.

Vancouver:

Copeland DM. A study of the interactions of nitric oxide and nitric oxide containing molecules with heme proteins. [Internet] [Doctoral dissertation]. University of Oklahoma; 2006. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/1101.

Council of Science Editors:

Copeland DM. A study of the interactions of nitric oxide and nitric oxide containing molecules with heme proteins. [Doctoral Dissertation]. University of Oklahoma; 2006. Available from: http://hdl.handle.net/11244/1101

University of Oklahoma

13. Xu, Hengyu. Mechanism of saccharopine dehydrogenase: The last enzyme in the lysine biosynthetic pathway in Saccharomyces cerevisiae.

Degree: PhD, Department of Chemistry and Biochemistry, 2007, University of Oklahoma

URL: http://hdl.handle.net/11244/1151

► Kinetic data have been measured for SDH from Saccharomyces cerevisiae , suggesting the ordered addition of NAD+ followed by saccharopine in the physiologic reaction direction.… (more)

Subjects/Keywords: Saccharomyces cerevisiae.; Enzymes.; Chemistry, Biochemistry.; Lysine Synthesis.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xu, H. (2007). Mechanism of saccharopine dehydrogenase: The last enzyme in the lysine biosynthetic pathway in Saccharomyces cerevisiae. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/1151

Chicago Manual of Style (16^th Edition):

Xu, Hengyu. “Mechanism of saccharopine dehydrogenase: The last enzyme in the lysine biosynthetic pathway in Saccharomyces cerevisiae.” 2007. Doctoral Dissertation, University of Oklahoma. Accessed March 09, 2021. http://hdl.handle.net/11244/1151.

MLA Handbook (7^th Edition):

Xu, Hengyu. “Mechanism of saccharopine dehydrogenase: The last enzyme in the lysine biosynthetic pathway in Saccharomyces cerevisiae.” 2007. Web. 09 Mar 2021.

Vancouver:

Xu H. Mechanism of saccharopine dehydrogenase: The last enzyme in the lysine biosynthetic pathway in Saccharomyces cerevisiae. [Internet] [Doctoral dissertation]. University of Oklahoma; 2007. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11244/1151.

Council of Science Editors:

Xu H. Mechanism of saccharopine dehydrogenase: The last enzyme in the lysine biosynthetic pathway in Saccharomyces cerevisiae. [Doctoral Dissertation]. University of Oklahoma; 2007. Available from: http://hdl.handle.net/11244/1151

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