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You searched for +publisher:"University of Oklahoma" +contributor:("Kenneth, Nicholas"). Showing records 1 – 2 of 2 total matches.

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University of Oklahoma

1. Ellis, Shawna Beth. ADVANCES TOWARD THE UTILIZATION OF CUCURBIT[7]URIL AND SELECTED VIOLOGENS IN MOLECULAR MACHINES AND DEVICES.

Degree: PhD, 2013, University of Oklahoma

The study of technology at the molecular level is the perhaps the final frontier in materials science, and is fertile ground for the application of supramolecular chemistry. Cucurbit[7]uril is a particularly unique macrocycle that encapsulates smaller molecules and has potential application in enhancing the properties of guest molecules. This study has highlighted the reasons that the application of cucurbit[7]uril should be in the forefront of these emerging fields. The studies herein have gathered sound data supporting the use of cucurbit[7]uril in a variety of molecular scale devices. For example, cyclic voltammetry is used to demonstrate the protective effects provided by cucubit[7]uril to prevent photobleaching of small molecules that are potentially useful in dye-sensitive solar cells. Also, modes of binding, kinetic binding constants, and equilibrium binding constants have been determined for a variety of host-guest complexes which could lead to the strategic incorporation of these molecules into molecular machines and devices. Not only has previously held knowledge about the interactions of this macrocycle been confirmed, but the results here have increased the sphere of knowledge and may also guide future studies in this promising field. Advisors/Committee Members: Halterman, Ronald (advisor), Daniel, Glatzhofer (committee member), Kenneth, Nicholas (committee member), Ann, West (committee member), Lloyd, Bumm (committee member).

Subjects/Keywords: Chemistry; Organic.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Ellis, S. B. (2013). ADVANCES TOWARD THE UTILIZATION OF CUCURBIT[7]URIL AND SELECTED VIOLOGENS IN MOLECULAR MACHINES AND DEVICES. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/6390

Chicago Manual of Style (16th Edition):

Ellis, Shawna Beth. “ADVANCES TOWARD THE UTILIZATION OF CUCURBIT[7]URIL AND SELECTED VIOLOGENS IN MOLECULAR MACHINES AND DEVICES.” 2013. Doctoral Dissertation, University of Oklahoma. Accessed March 25, 2019. http://hdl.handle.net/11244/6390.

MLA Handbook (7th Edition):

Ellis, Shawna Beth. “ADVANCES TOWARD THE UTILIZATION OF CUCURBIT[7]URIL AND SELECTED VIOLOGENS IN MOLECULAR MACHINES AND DEVICES.” 2013. Web. 25 Mar 2019.

Vancouver:

Ellis SB. ADVANCES TOWARD THE UTILIZATION OF CUCURBIT[7]URIL AND SELECTED VIOLOGENS IN MOLECULAR MACHINES AND DEVICES. [Internet] [Doctoral dissertation]. University of Oklahoma; 2013. [cited 2019 Mar 25]. Available from: http://hdl.handle.net/11244/6390.

Council of Science Editors:

Ellis SB. ADVANCES TOWARD THE UTILIZATION OF CUCURBIT[7]URIL AND SELECTED VIOLOGENS IN MOLECULAR MACHINES AND DEVICES. [Doctoral Dissertation]. University of Oklahoma; 2013. Available from: http://hdl.handle.net/11244/6390


University of Oklahoma

2. Nkepang, Gregory. DEVELOPMENT OF A NEW SYNTHETIC SCHEME FOR VINYL DIETHERS AND SYNTHESIS OF PRODRUGS FOR TARGETED DELIVERY AND VISIBLE/NIR LIGHT-TRIGGERED RELEASE.

Degree: PhD, 2014, University of Oklahoma

Tumor specific drug delivery has become increasingly interesting in cancer therapy, as the use of chemotherapeutics is often limited due to severe side effects. Targeted chemotherapy for cancer treatment offers a great potential advantage in tumor treatment due to greater specificity of delivery, which leads to an increased dose of the cytotoxin delivered to the malignant cells relative to healthy cells in the rest of the body. There are two general directions in anticancer drug delivery that focus on achieving a high local drug concentration specifically in the cancerous tissue while reducing its uptake in healthy cells. i) Site-specific delivery can be achieved by conjugating the drug or coating the delivery vehicle (liposomes, micelles, etc.) with ligands or antibodies that target overexpressed receptors in the tumor tissue. This could also possibly be used to direct a drug away from the body sites that are sensitive to the toxic action of the carried drug (site avoidance). ii) By incorporating an active and site-specific release mechanism within the prodrug or delivery vehicle, it is possible to increase the release and therapeutic efficacy of the cytotoxic agent. A chemotherapeutic drug delivery system designed to combine these two principles (site–specific targeting and site-specific triggering) will fulfill Paul Ehrich’s vision of a magic bullet in the treatment of diseases there by overcoming the selectivity problems of conventional chemotherapy. The folate receptor (FR) is a potentially useful biological target for the management of human cancers. Owing to the overexpression of the FRs on the surface of malignant cells, conjugation of the cytotoxic agent to folic acid (FA) via suitable spacers has demonstrated the enhanced selective drug delivery to the tumor site. Furthermore the degree of over-expression has been found to correlate with the stage of tumor growth. Various FA-conjugated prodrugs and folate targeted delivery vehicles have been synthesized and are currently in preclinical and clinical trials. Biotin (vitamin B7) is also an essential cellular micronutrient responsible for various normal cellular functions, and its receptors are overexpressed in various cancer cell lines. It has been suggested that the sodium dependent multivitamin transporter (SMVT) is responsible for the uptake of biotin. It has also been indicated that there has been a higher expression of SMVT in several lung, renal, colon and breast cancer cell lines than FR. Several biotinylated anticancer agents have also been used in the selective delivery to cell lines overexpressing the SMVTs. Most of the folate and biotinylated conjugates are equipped with release mechanisms that rely on intrinsic activating agents such as small changes in temperature, pH differences, enzyme and an external activating tool such as light triggered release (light of shorter wavelengths). The use of light of longer wavelengths with better tissue penetration to active release of the drugs is warranted, which then will lead to the search for novel… Advisors/Committee Members: Kenneth, Nicholas (advisor), You, Youngjae (committee member), Glatzhofer, Daniel (committee member), Yip, Wai Tak (committee member), Wayne, Elisens (committee member).

Subjects/Keywords: Drug Delivery

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Nkepang, G. (2014). DEVELOPMENT OF A NEW SYNTHETIC SCHEME FOR VINYL DIETHERS AND SYNTHESIS OF PRODRUGS FOR TARGETED DELIVERY AND VISIBLE/NIR LIGHT-TRIGGERED RELEASE. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/7918

Chicago Manual of Style (16th Edition):

Nkepang, Gregory. “DEVELOPMENT OF A NEW SYNTHETIC SCHEME FOR VINYL DIETHERS AND SYNTHESIS OF PRODRUGS FOR TARGETED DELIVERY AND VISIBLE/NIR LIGHT-TRIGGERED RELEASE.” 2014. Doctoral Dissertation, University of Oklahoma. Accessed March 25, 2019. http://hdl.handle.net/11244/7918.

MLA Handbook (7th Edition):

Nkepang, Gregory. “DEVELOPMENT OF A NEW SYNTHETIC SCHEME FOR VINYL DIETHERS AND SYNTHESIS OF PRODRUGS FOR TARGETED DELIVERY AND VISIBLE/NIR LIGHT-TRIGGERED RELEASE.” 2014. Web. 25 Mar 2019.

Vancouver:

Nkepang G. DEVELOPMENT OF A NEW SYNTHETIC SCHEME FOR VINYL DIETHERS AND SYNTHESIS OF PRODRUGS FOR TARGETED DELIVERY AND VISIBLE/NIR LIGHT-TRIGGERED RELEASE. [Internet] [Doctoral dissertation]. University of Oklahoma; 2014. [cited 2019 Mar 25]. Available from: http://hdl.handle.net/11244/7918.

Council of Science Editors:

Nkepang G. DEVELOPMENT OF A NEW SYNTHETIC SCHEME FOR VINYL DIETHERS AND SYNTHESIS OF PRODRUGS FOR TARGETED DELIVERY AND VISIBLE/NIR LIGHT-TRIGGERED RELEASE. [Doctoral Dissertation]. University of Oklahoma; 2014. Available from: http://hdl.handle.net/11244/7918

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