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You searched for +publisher:"University of Notre Dame" +contributor:("Professor Richard E. Taylor, Committee Member"). Showing records 1 – 2 of 2 total matches.

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University of Notre Dame

1. Shanshan Yan. Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>.

Degree: MS, Chemistry and Biochemistry, 2009, University of Notre Dame

The research in this thesis involved two main projects that focus on the development of novel antibiotics to overcome bacterial resistance problem. The first project involved the syntheses and biological evaluation of cephalosporin and oxazolidinone-based antibiotics using nitroso DielsÌ¢�âÂ"Alder and related chemistry. The second main project involved the syntheses and biological studies of cephalosporin-oxazolidinone dual action prodrugs. In Chapter 1, the synthesis of cephalosporin-based antibiotics using nitroso DielsÌ¢�âÂ"Alder chemistry was rationalized and described. Chapter 2 described the synthesis of novel oxazine and aminocycloalkenol containing oxazolidinone antibiotics using nitroso DielsÌ¢�âÂ"Alder chemistry. In addition, in vitro antibacterial studies were included. In chapter 3, cephalosporin-oxazolidinone multifunctional compounds were rationally designed and synthesized. Their stability in aqueous media in the presence of Beta-lactamase and in vitro antimicrobial activity were investigated Advisors/Committee Members: Professor Xavier Creary , Committee Member, Professor Bradley D. Smith, Committee Member, Professor Richard E. Taylor, Committee Member, Professor Marvin J. Miller, Committee Member.

Subjects/Keywords: Cephalosporin; Oxazolidinone; Conjugate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Yan, S. (2009). Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>. (Masters Thesis). University of Notre Dame. Retrieved from https://curate.nd.edu/show/qn59q239z0q

Chicago Manual of Style (16th Edition):

Yan, Shanshan. “Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>.” 2009. Masters Thesis, University of Notre Dame. Accessed August 24, 2019. https://curate.nd.edu/show/qn59q239z0q.

MLA Handbook (7th Edition):

Yan, Shanshan. “Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>.” 2009. Web. 24 Aug 2019.

Vancouver:

Yan S. Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>. [Internet] [Masters thesis]. University of Notre Dame; 2009. [cited 2019 Aug 24]. Available from: https://curate.nd.edu/show/qn59q239z0q.

Council of Science Editors:

Yan S. Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>. [Masters Thesis]. University of Notre Dame; 2009. Available from: https://curate.nd.edu/show/qn59q239z0q


University of Notre Dame

2. Edward J O'Neil. Synthesis and Study of Membrane Active Compounds</h1>.

Degree: PhD, Chemistry and Biochemistry, 2008, University of Notre Dame

This dissertation describes the design, synthesis, and activity of molecules that interact specifically with vesicle or cellular membranes. The first section describes a series of second generation Zn2+ bis DPA coordination complexes that selectively target negatively charged membrane surfaces including those found in apoptotic cells and bacteria. Several types of conjugates were constructed including fluorescent versions suitable for microscopy, multivalent receptors designed for increased membrane affinity, and lipophilic derivatives. The synthesis and membrane activity of each is discussed. The second portion of this dissertation describes general strategies for the synthesis of sn-2 functionalized phospholipids from DPPC. Phospholipases were utilized for selective headgroup and side chain modification of commercially available phospholipids circumventing a de novo synthetic approach. Several classes of functionalized phosphatidylcholine derivatives were constructed including bolaamphiphiles which in some cases were found to destabilize membranes and chloride anion transporters that function by a novel relay mechanism. Other phospholipid derivatives include phosphatidylserine and phosphatidylethanolamine conjugates that were designed for receptor-mediated delivery of cargo into cells. Advisors/Committee Members: Professor Paul Helquist, Committee Member, Professor Shahriar Mobashery, Committee Member, Professor Richard E. Taylor, Committee Member.

Subjects/Keywords: cellular membrane; cellular delivery; phospholipid; bolaamphiphile; chloride transport; phosphatidylserine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

O'Neil, E. J. (2008). Synthesis and Study of Membrane Active Compounds</h1>. (Doctoral Dissertation). University of Notre Dame. Retrieved from https://curate.nd.edu/show/sb397655p2z

Chicago Manual of Style (16th Edition):

O'Neil, Edward J. “Synthesis and Study of Membrane Active Compounds</h1>.” 2008. Doctoral Dissertation, University of Notre Dame. Accessed August 24, 2019. https://curate.nd.edu/show/sb397655p2z.

MLA Handbook (7th Edition):

O'Neil, Edward J. “Synthesis and Study of Membrane Active Compounds</h1>.” 2008. Web. 24 Aug 2019.

Vancouver:

O'Neil EJ. Synthesis and Study of Membrane Active Compounds</h1>. [Internet] [Doctoral dissertation]. University of Notre Dame; 2008. [cited 2019 Aug 24]. Available from: https://curate.nd.edu/show/sb397655p2z.

Council of Science Editors:

O'Neil EJ. Synthesis and Study of Membrane Active Compounds</h1>. [Doctoral Dissertation]. University of Notre Dame; 2008. Available from: https://curate.nd.edu/show/sb397655p2z

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