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You searched for +publisher:"University of Notre Dame" +contributor:("Professor Bradley D. Smith, Committee Member"). One record found.

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University of Notre Dame

1. Shanshan Yan. Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>.

Degree: MS, Chemistry and Biochemistry, 2009, University of Notre Dame

The research in this thesis involved two main projects that focus on the development of novel antibiotics to overcome bacterial resistance problem. The first project involved the syntheses and biological evaluation of cephalosporin and oxazolidinone-based antibiotics using nitroso DielsÌ¢�âÂ"Alder and related chemistry. The second main project involved the syntheses and biological studies of cephalosporin-oxazolidinone dual action prodrugs. In Chapter 1, the synthesis of cephalosporin-based antibiotics using nitroso DielsÌ¢�âÂ"Alder chemistry was rationalized and described. Chapter 2 described the synthesis of novel oxazine and aminocycloalkenol containing oxazolidinone antibiotics using nitroso DielsÌ¢�âÂ"Alder chemistry. In addition, in vitro antibacterial studies were included. In chapter 3, cephalosporin-oxazolidinone multifunctional compounds were rationally designed and synthesized. Their stability in aqueous media in the presence of Beta-lactamase and in vitro antimicrobial activity were investigated Advisors/Committee Members: Professor Xavier Creary , Committee Member, Professor Bradley D. Smith, Committee Member, Professor Richard E. Taylor, Committee Member, Professor Marvin J. Miller, Committee Member.

Subjects/Keywords: Cephalosporin; Oxazolidinone; Conjugate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Yan, S. (2009). Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>. (Masters Thesis). University of Notre Dame. Retrieved from https://curate.nd.edu/show/qn59q239z0q

Chicago Manual of Style (16th Edition):

Yan, Shanshan. “Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>.” 2009. Masters Thesis, University of Notre Dame. Accessed August 20, 2019. https://curate.nd.edu/show/qn59q239z0q.

MLA Handbook (7th Edition):

Yan, Shanshan. “Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>.” 2009. Web. 20 Aug 2019.

Vancouver:

Yan S. Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>. [Internet] [Masters thesis]. University of Notre Dame; 2009. [cited 2019 Aug 20]. Available from: https://curate.nd.edu/show/qn59q239z0q.

Council of Science Editors:

Yan S. Design, Syntheses and Biological Evaluation of Novel Cephalosporin and Oxazolidinone-Based Antibiotics</h1>. [Masters Thesis]. University of Notre Dame; 2009. Available from: https://curate.nd.edu/show/qn59q239z0q

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