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You searched for +publisher:"University of North Dakota" +contributor:("Edward C. Carlson"). One record found.

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1. Hewitt, Holly M. Targeted Overexpression Of Metallothionein In Endothelial Cells Mitigates Pulmonary Alveolar Basement Membrane Thickening In Transgenic Diabetic Ove Mice: An Unbiased Tem Morphometric Analysis.

Degree: MS, Biology, 2013, University of North Dakota

Damage to small blood vessels in diabetes mellitus (DM) is largely the result of hyperglycemia-driven oxidative stress. This is manifested morphologically by capillary basement membrane (BM) thickening, the hallmark feature of chronic complications of DM. In an effort to demonstrate pulmonary alveolar BM (PABM) thickness increase in DM and to demonstrate for the first time, mitigation of the increase utilizing antioxidant therapy, we crossed the severely diabetic transgenic mouse (OVE) with Jtmt, our recently developed transgenic animal model that overexpresses the antioxidant metallothionein (MT) in endothelial cells. Unbiased TEM morphometry demonstrated that PABM widths in diabetic (OVE) mice were significantly (+20%) thickened. Remarkably, however, the bi-transgenic OVEJtmt progney exhibited statistically significant protection against DM-derived BM thickening. These results provide evidence for a direct role of oxidative damage to endothelial cells in diabetic mice and show that protection of these cells can reduce one of the primary features of diabetic microangiopathy. Advisors/Committee Members: Edward C. Carlson.

Subjects/Keywords: Basement membrane; Diabetes; Endothelial cells; Metallothionein; Morphometric analysis; Pulmonary

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hewitt, H. M. (2013). Targeted Overexpression Of Metallothionein In Endothelial Cells Mitigates Pulmonary Alveolar Basement Membrane Thickening In Transgenic Diabetic Ove Mice: An Unbiased Tem Morphometric Analysis. (Masters Thesis). University of North Dakota. Retrieved from https://commons.und.edu/theses/1542

Chicago Manual of Style (16th Edition):

Hewitt, Holly M. “Targeted Overexpression Of Metallothionein In Endothelial Cells Mitigates Pulmonary Alveolar Basement Membrane Thickening In Transgenic Diabetic Ove Mice: An Unbiased Tem Morphometric Analysis.” 2013. Masters Thesis, University of North Dakota. Accessed July 15, 2019. https://commons.und.edu/theses/1542.

MLA Handbook (7th Edition):

Hewitt, Holly M. “Targeted Overexpression Of Metallothionein In Endothelial Cells Mitigates Pulmonary Alveolar Basement Membrane Thickening In Transgenic Diabetic Ove Mice: An Unbiased Tem Morphometric Analysis.” 2013. Web. 15 Jul 2019.

Vancouver:

Hewitt HM. Targeted Overexpression Of Metallothionein In Endothelial Cells Mitigates Pulmonary Alveolar Basement Membrane Thickening In Transgenic Diabetic Ove Mice: An Unbiased Tem Morphometric Analysis. [Internet] [Masters thesis]. University of North Dakota; 2013. [cited 2019 Jul 15]. Available from: https://commons.und.edu/theses/1542.

Council of Science Editors:

Hewitt HM. Targeted Overexpression Of Metallothionein In Endothelial Cells Mitigates Pulmonary Alveolar Basement Membrane Thickening In Transgenic Diabetic Ove Mice: An Unbiased Tem Morphometric Analysis. [Masters Thesis]. University of North Dakota; 2013. Available from: https://commons.und.edu/theses/1542

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