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You searched for +publisher:"University of North Carolina" +contributor:("Wang, Xiao"). One record found.

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University of North Carolina

1. Wang, Xiao. Mathematical modeling of signaling pathway dynamics and stochastic gene expression.

Degree: Statistics and Operations Research, 2006, University of North Carolina

This thesis presents the development and analysis of stochastic and deterministic models of cellular biochemical networks, such as signaling pathways and gene regulatory networks. First, the model of the yeast pheromone response pathway is constructed. Stochastic modeling reveals that the biochemical steps that regulate activation of the mitogen-activated protein kinase Fus3 can account for the graded-to-binary conversion. The model is also used to investigate the effects of protein turnover on the response of the pathway. It is demonstrated that the inclusion of protein turnover can lead too sustained oscillations of protein concentration in the absence of feedback regulation, which indicates protein turnover as a important signaling regulation mechanism. Second, an engineered promoter that allowed the simultaneous repression and activation of gene expression in Escherichia coli was constructed and used to construct a stochastic model to study synthetic gene networks under increasingly complex conditions: unregulated, repressed, activated and simultaneously repressed and activated, and in the presence of positive feedback. The stochastic model quantitatively captures the means and distributions of the expression from the engineered promoter of this modular system and accurately predict the in vivo behavior of an expanded network that includes positive feedback. The model also reveals the counterintuitive prediction that noise in protein expression levels can increase upon arrest of cell division, which was confirmed experimentally. Advisors/Committee Members: Wang, Xiao, Elston, Timothy.

Subjects/Keywords: College of Arts and Sciences; Department of Statistics and Operations Research

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wang, X. (2006). Mathematical modeling of signaling pathway dynamics and stochastic gene expression. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:c7a16d02-032d-4369-9f65-6008f4822504

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Wang, Xiao. “Mathematical modeling of signaling pathway dynamics and stochastic gene expression.” 2006. Thesis, University of North Carolina. Accessed December 04, 2020. https://cdr.lib.unc.edu/record/uuid:c7a16d02-032d-4369-9f65-6008f4822504.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Wang, Xiao. “Mathematical modeling of signaling pathway dynamics and stochastic gene expression.” 2006. Web. 04 Dec 2020.

Vancouver:

Wang X. Mathematical modeling of signaling pathway dynamics and stochastic gene expression. [Internet] [Thesis]. University of North Carolina; 2006. [cited 2020 Dec 04]. Available from: https://cdr.lib.unc.edu/record/uuid:c7a16d02-032d-4369-9f65-6008f4822504.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang X. Mathematical modeling of signaling pathway dynamics and stochastic gene expression. [Thesis]. University of North Carolina; 2006. Available from: https://cdr.lib.unc.edu/record/uuid:c7a16d02-032d-4369-9f65-6008f4822504

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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