Open Access Theses and Dissertations

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You searched for +publisher:"University of North Carolina" +contributor:("Vicci, Leandra"). Showing records 1 – 2 of 2 total matches.

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University of North Carolina

1. Spero, Richard. Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization.

Degree: Physics and Astronomy, 2010, University of North Carolina

URL: https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796 

The formation, function, and lysis of blood clots is largely governed by the transport of nano- and micro-scale particles. Yet there is not fully established physics that relates clot structure to transport phenomena such as fluid permeation and particle diffusion. This dissertation explores small particle transport in fibrin. I report on the size-dependence of particle mobility in fibrin, and discuss the implications of these results for fibrinolytic drug design. I measure the relationship between fibrin permeability and diffusion of 0.2 – 2.8 micron particles in fibrin gels, then determine the time and length scales at which small particle diffusion is directly related to bulk gel permeability. This result implies that one could develop a high throughput clot characterization assay that provides more detail than turbidity, the predominant high throughput measurement. I also present my work designing and developing systems to perform these and other experiments in high throughput, which include novel technologies for optical microscopy and magnetic force application. Advisors/Committee Members: Spero, Richard, Superfine, Richard, Falvo, Michael, Forest, M. Gregory, Vicci, Leandra, Washburn, Sean, Wolberg, Alisa.

Subjects/Keywords: College of Arts and Sciences; Department of Physics and Astronomy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Spero, R. (2010). Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Spero, Richard. “Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization.” 2010. Thesis, University of North Carolina. Accessed January 21, 2021. https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Spero, Richard. “Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization.” 2010. Web. 21 Jan 2021.

Vancouver:

Spero R. Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization. [Internet] [Thesis]. University of North Carolina; 2010. [cited 2021 Jan 21]. Available from: https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Spero R. Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization. [Thesis]. University of North Carolina; 2010. Available from: https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of North Carolina

2. Zhao, Longhua. Fluid-Structure Interaction in Viscous Dominated Flows.

Degree: Mathematics, 2010, University of North Carolina

URL: https://cdr.lib.unc.edu/record/uuid:58280df9-00dd-437f-b1b6-5b59bd632177 

Theoretical, numerical and experimental studies for several flows in the Low Reynolds number regime are reported in this thesis. It includes the flow structure and blocking phenomena in linear shear or rotation flow past an embedded rigid body, and flows induced by a slender rod precessing a cone to imitate the motion of nodal cilia are studied with the singularity method. The first subject is to explore interesting phenomena emerging in the fundamental problem of shear flow past rigid obstacles. An analytical and computational study of Lagrangian trajectories for linear shear flow past a sphere or spheroid at low Reynolds numbers is presented. Using the exact solutions available for the fluid flow in this geometry, we explore and analyze blocking phenomena, local bifurcation structures and their influences on dynamical effects arising in the fluid particle paths. In particular, based on the work by Chwang and Wu who established a blocking phenomenon in two-dimensional flows, whereby a cylinder placed in a linear shear prevents an unbounded region of upstream fluid from passing the body, we show that a similar blocking exists in three-dimensional flows. For the special case when the sphere is centered on the zero-velocity plane of the background shear, the separatrix streamline surfaces which bound the blocked region are computable in closed form by quadrature. With such analytical results, we study the foliation of the physical material streamline surfaces, identify the separation in the flow, and measure the blocked flow. When the sphere's center is out of the zero-velocity plane of the background shear, closed form expressions appear unavailable due to the broken up-down mirror symmetry. In this case, computations provide evidences for the persistence of the blocking region. Furthermore, a complex bifurcation structure in the particle trajectories is documented. We compute analytically the emergence of different critical points in the flow and characterize the global streamline topology associated with these critical points, which includes the emergence of a three-dimensional bounded eddy. Additionally, we study the case of a sphere embedded at a generic position in a rotating background flow, with its own prescribed rotation including fixed and freely rotating. Exact closed form solutions for fluid particle trajectories, stagnation points on the sphere, and critical points in the interior of the flow are derived. We extend our results further to spheroids as well, where similar blocking results are documented. The broken symmetry offered by a tilted spheroid geometry induces new three-dimensional effects on the streamline deflection, which can be viewed as effective positive or negative suction in the horizontal direction orthogonal to the background flow depending on the tilt orientation. We close this study with results of a spheroid embedded in a rotating background flow, with its own prescribed tilt orientation. Net fluid transport is observed in this flow, where the direction of transport depends on the… Advisors/Committee Members: Zhao, Longhua, Camassa, Roberto, McLaughlin, Richard, Forest, M. Gregory, Miller, Laura, Superfine, Richard, Vicci, Leandra.

Subjects/Keywords: College of Arts and Sciences; Department of Mathematics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Zhao, L. (2010). Fluid-Structure Interaction in Viscous Dominated Flows. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:58280df9-00dd-437f-b1b6-5b59bd632177

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Zhao, Longhua. “Fluid-Structure Interaction in Viscous Dominated Flows.” 2010. Thesis, University of North Carolina. Accessed January 21, 2021. https://cdr.lib.unc.edu/record/uuid:58280df9-00dd-437f-b1b6-5b59bd632177.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Zhao, Longhua. “Fluid-Structure Interaction in Viscous Dominated Flows.” 2010. Web. 21 Jan 2021.

Vancouver:

Zhao L. Fluid-Structure Interaction in Viscous Dominated Flows. [Internet] [Thesis]. University of North Carolina; 2010. [cited 2021 Jan 21]. Available from: https://cdr.lib.unc.edu/record/uuid:58280df9-00dd-437f-b1b6-5b59bd632177.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhao L. Fluid-Structure Interaction in Viscous Dominated Flows. [Thesis]. University of North Carolina; 2010. Available from: https://cdr.lib.unc.edu/record/uuid:58280df9-00dd-437f-b1b6-5b59bd632177

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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