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You searched for +publisher:"University of North Carolina" +contributor:("Vasquez, Paula"). Showing records 1 – 2 of 2 total matches.

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University of North Carolina

1. Jin, Yuan. RHEOLOGY AND FLOW OF MUCUS IN HUMAN BRONCHIAL EPITHELIAL CELL CULTURES.

Degree: Mathematics, 2015, University of North Carolina

The propulsion of mucus in human airways toward the trachea by the collective and coordinated action of cilia, known as mucociliary clearance, remains an outstanding modeling and computational challenge. A model system for mucociliary clearance is provided by human bronchial epithelial (HBE) cell cultures that generate macroscopic mean rotational flow. We coarse grain the coordinated cilia propulsion into an imposed dynamic velocity condition on the flat base of a cylinder. A multi-mode Giseskus nonlinear viscoelastic constitutive model derived from rheological data of mucus is employed for the mucus layer. The full system of governing equations for the transient and stationary axisymmetric flow field and air-mucus interface is solved numerically. Our modeling is the first step toward a platform for several purposes: to test accuracy of the constitutive modeling of mucus; to build a faithful model of the cilia-mucus boundary condition; to simulate both the flow and stress fields throughout the mucus layer; to explore the linear and nonlinear viscoelastic behavior of the mucus flow; and to explore the advection-diffusion process of a drug concentration dropped at the surface of the cell culture, and illustrate how the absorption by the bottom plate varies versus the initial drop position and the diffusion coefficient. Advisors/Committee Members: Jin, Yuan, Forest, M. Gregory, Vasquez, Paula, Hill, David, Huang, Jingfang, Miller, Laura.

Subjects/Keywords: Mathematics; College of Arts and Sciences; Department of Mathematics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jin, Y. (2015). RHEOLOGY AND FLOW OF MUCUS IN HUMAN BRONCHIAL EPITHELIAL CELL CULTURES. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:542a92cc-4718-4ac3-a7b1-b133c946a068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Jin, Yuan. “RHEOLOGY AND FLOW OF MUCUS IN HUMAN BRONCHIAL EPITHELIAL CELL CULTURES.” 2015. Thesis, University of North Carolina. Accessed October 27, 2020. https://cdr.lib.unc.edu/record/uuid:542a92cc-4718-4ac3-a7b1-b133c946a068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Jin, Yuan. “RHEOLOGY AND FLOW OF MUCUS IN HUMAN BRONCHIAL EPITHELIAL CELL CULTURES.” 2015. Web. 27 Oct 2020.

Vancouver:

Jin Y. RHEOLOGY AND FLOW OF MUCUS IN HUMAN BRONCHIAL EPITHELIAL CELL CULTURES. [Internet] [Thesis]. University of North Carolina; 2015. [cited 2020 Oct 27]. Available from: https://cdr.lib.unc.edu/record/uuid:542a92cc-4718-4ac3-a7b1-b133c946a068.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jin Y. RHEOLOGY AND FLOW OF MUCUS IN HUMAN BRONCHIAL EPITHELIAL CELL CULTURES. [Thesis]. University of North Carolina; 2015. Available from: https://cdr.lib.unc.edu/record/uuid:542a92cc-4718-4ac3-a7b1-b133c946a068

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of North Carolina

2. Hult, Caitlin. Modeling Nucleosomal DNA in Living Yeast.

Degree: Mathematics, 2017, University of North Carolina

The genome in living yeast cells is a highly dynamic system where entropic interactions and nuclear confinement drive the formation of domains of high chromosomal interaction, known as topologically associating domains. We investigate dynamic organization and territory formation of 16 chromosomes in living yeast cells during interphase, using coarse-grained, entropic polymer chain models. We are interested in determining the mechanisms, such as packaging molecules that create loops within chromatin fibers, that govern inter- and intra-chromatin fluctuations and induce global features of the entire genome as well as more localized features of the nucleolus. The Bloom Lab measures specific DNA sites in specific chromosomes using live cell fluorescence microscopy. Our goal is to identify the sufficient biological and biophysical assumptions necessary to reproduce the experimental data, from which we aim to shed insights into dynamics and structure that are beyond current experimental resolution. In this dissertation, we show through a reductionist 3D mathematical model that entropic interactions are the driving mechanisms of the formation of domains of high chromosomal interaction and that enzymatic processes modulate the spatiotemporal dynamics of these domains. We present novel modeling and visualization techniques for nucleolus spatiotemporal dynamics. We explore the minimal physical requirements to segregate this region of repeated DNA from the rest of the genome, with a particular emphasis on the role of transient loop formation. Our findings support and significantly expand upon previous work. Advisors/Committee Members: Hult, Caitlin, Forest, Mark, Adalsteinsson, David, Bloom, Kerry, Griffith, Boyce, Vasquez, Paula.

Subjects/Keywords: College of Arts and Sciences; Department of Mathematics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hult, C. (2017). Modeling Nucleosomal DNA in Living Yeast. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:da4bbc26-4bdf-416d-accc-4d1631067d82

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Hult, Caitlin. “Modeling Nucleosomal DNA in Living Yeast.” 2017. Thesis, University of North Carolina. Accessed October 27, 2020. https://cdr.lib.unc.edu/record/uuid:da4bbc26-4bdf-416d-accc-4d1631067d82.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Hult, Caitlin. “Modeling Nucleosomal DNA in Living Yeast.” 2017. Web. 27 Oct 2020.

Vancouver:

Hult C. Modeling Nucleosomal DNA in Living Yeast. [Internet] [Thesis]. University of North Carolina; 2017. [cited 2020 Oct 27]. Available from: https://cdr.lib.unc.edu/record/uuid:da4bbc26-4bdf-416d-accc-4d1631067d82.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hult C. Modeling Nucleosomal DNA in Living Yeast. [Thesis]. University of North Carolina; 2017. Available from: https://cdr.lib.unc.edu/record/uuid:da4bbc26-4bdf-416d-accc-4d1631067d82

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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