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You searched for +publisher:"University of North Carolina" +contributor:("Spero, Richard"). One record found.

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University of North Carolina

1. Spero, Richard. Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization.

Degree: Physics and Astronomy, 2010, University of North Carolina

The formation, function, and lysis of blood clots is largely governed by the transport of nano- and micro-scale particles. Yet there is not fully established physics that relates clot structure to transport phenomena such as fluid permeation and particle diffusion. This dissertation explores small particle transport in fibrin. I report on the size-dependence of particle mobility in fibrin, and discuss the implications of these results for fibrinolytic drug design. I measure the relationship between fibrin permeability and diffusion of 0.2 – 2.8 micron particles in fibrin gels, then determine the time and length scales at which small particle diffusion is directly related to bulk gel permeability. This result implies that one could develop a high throughput clot characterization assay that provides more detail than turbidity, the predominant high throughput measurement. I also present my work designing and developing systems to perform these and other experiments in high throughput, which include novel technologies for optical microscopy and magnetic force application. Advisors/Committee Members: Spero, Richard, Superfine, Richard, Falvo, Michael, Forest, M. Gregory, Vicci, Leandra, Washburn, Sean, Wolberg, Alisa.

Subjects/Keywords: College of Arts and Sciences; Department of Physics and Astronomy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Spero, R. (2010). Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Spero, Richard. “Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization.” 2010. Thesis, University of North Carolina. Accessed November 30, 2020. https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Spero, Richard. “Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization.” 2010. Web. 30 Nov 2020.

Vancouver:

Spero R. Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization. [Internet] [Thesis]. University of North Carolina; 2010. [cited 2020 Nov 30]. Available from: https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Spero R. Small Particle Transport in Fibrin Gels and High Throughput Clot Characterization. [Thesis]. University of North Carolina; 2010. Available from: https://cdr.lib.unc.edu/record/uuid:56b1a8f5-914c-49d9-930d-73ede3675796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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