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You searched for +publisher:"University of North Carolina" +contributor:("Smith, Austin"). Showing records 1 – 2 of 2 total matches.

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University of North Carolina

1. Smith, Austin Gerald. Lewis acid-promoted Friedel-Crafts alkylation of alpha-ketophosphate electrophiles.

Degree: Chemistry, 2011, University of North Carolina

I. Lewis Acid-Promoted Friedel-Crafts Alkylation of alpha-Ketophosphate Electrophiles: The alpha-alkylation of alpha-ketophosphate electrophiles by electron-rich neutral nucleophiles is described. The reaction is promoted by either BF3.OEt2 or ZnCl2. Aromatic, heteroaromatic, heteroatom and nonaromatic nucleophiles are tolerated. Electron-rich alpha-ketophosphates display the highest reactivity; electron-neutral and electron-poor substrates are also tolerated at elevated temperatures. Enantioenriched alpha-ketophosphate yields racemic product, lending evidence to an alpha-acyl carbenium ion intermediate. II. (3+2)-Annulation of Quaternary Donor-Acceptor Cyclopropanes and Aldehydes: The (3+2)-annulation of all-carbon donor site donor-acceptor cyclopropanes and aldehydes is described. Catalytic Sn(II), Sn(IV), or Hf(IV) facilitates the diastereoselective annulation. One-step access to highly substituted cis-tetrahydrofurans is possible. The reaction is tolerant of electron-rich and electron poor aromatic aldehydes, as well as alkenyl and aliphatic aldehydes. Mechanistic experiments with optically active cyclopropanes suggest an aldehyde nucleophilic substitution mechanism is operative and demonstrate that chirality transfer to the tetrahydrofuran products is possible. III. Enantioselective Synthesis of of Pyrrolidines From Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights A dynamic kinetic asymmetric (3+2)-annulation of racemic D-A cyclopropanes and N-benzyl aromatic aldimines is described. Enantio- and diastereoselective access to 2,5-cis pyrrolidines is possible through the use of a (4-Br-tBu-pybox)MgI2 catalyst. Results from experiments with cyclically-constrained (Z)-aldimine suggest that the major cis-isomer in the DyKAT is not a product of a (Z)-aldimine pathway. Advisors/Committee Members: Smith, Austin Gerald, Johnson, Jeffrey.

Subjects/Keywords: College of Arts and Sciences; Department of Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Smith, A. G. (2011). Lewis acid-promoted Friedel-Crafts alkylation of alpha-ketophosphate electrophiles. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:19a3bc2c-414e-4b1b-8e3f-89e45d62d2c2

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Smith, Austin Gerald. “Lewis acid-promoted Friedel-Crafts alkylation of alpha-ketophosphate electrophiles.” 2011. Thesis, University of North Carolina. Accessed January 17, 2021. https://cdr.lib.unc.edu/record/uuid:19a3bc2c-414e-4b1b-8e3f-89e45d62d2c2.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Smith, Austin Gerald. “Lewis acid-promoted Friedel-Crafts alkylation of alpha-ketophosphate electrophiles.” 2011. Web. 17 Jan 2021.

Vancouver:

Smith AG. Lewis acid-promoted Friedel-Crafts alkylation of alpha-ketophosphate electrophiles. [Internet] [Thesis]. University of North Carolina; 2011. [cited 2021 Jan 17]. Available from: https://cdr.lib.unc.edu/record/uuid:19a3bc2c-414e-4b1b-8e3f-89e45d62d2c2.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Smith AG. Lewis acid-promoted Friedel-Crafts alkylation of alpha-ketophosphate electrophiles. [Thesis]. University of North Carolina; 2011. Available from: https://cdr.lib.unc.edu/record/uuid:19a3bc2c-414e-4b1b-8e3f-89e45d62d2c2

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of North Carolina

2. Smith, Austin. PROTEIN STRUCTURE, STABILITY AND DYNAMICS IN CELLS AND CELL-LIKE ENVIRONMENTS.

Degree: Chemistry, 2015, University of North Carolina

The intracellular milieu is filled with small molecules, nucleic acids, lipids and proteins. Theories have attempted to explain how macromolecules react to this environment for over 30 years. Recent experiment-based studies have shown that protein stability and dynamics are altered in this environment. I used the loop of chymotrypsin inhibitor 2 and two unfolded proteins (α-synuclein and FlgM) to show that the crowded cellular matrix does not necessarily cause structuring of these dynamic regions. Most importantly, I have shown the thermodynamic and mechanistic basis for how protein stability is changed in the cellular environment. To do this I use a marginally stable globular protein (an isolated SH3 domain) to measure stability, dynamics, and folding rates in cells and cell-like environments. Proteins are enthalpically destabilized in cells. The destabilization arises from charge-charge interactions of the cellular environment with the unfolded ensemble of the protein. These interactions also slow folding of the protein. This work will allow creation of a more complete picture of protein thermodynamics inside the cell. Furthermore, the SH3 domain is amenable to studying in vitro protein stability over a broad range of pH values, and allows acquisition of folding and unfolding rates with a variety of crowders. Future efforts will facilitate a better understanding of surface charge interactions and will allow elucidation of a crowder’s interaction with the transition state. Advisors/Committee Members: Smith, Austin, Pielak, Gary J., Thompson, Nancy, Lee, Andrew, Spremulli, Linda, Berkowitz, Max.

Subjects/Keywords: Chemistry; Biophysics; Biochemistry; College of Arts and Sciences; Department of Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Smith, A. (2015). PROTEIN STRUCTURE, STABILITY AND DYNAMICS IN CELLS AND CELL-LIKE ENVIRONMENTS. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:19a082d1-c0ab-4254-a131-5445a0502aed

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Smith, Austin. “PROTEIN STRUCTURE, STABILITY AND DYNAMICS IN CELLS AND CELL-LIKE ENVIRONMENTS.” 2015. Thesis, University of North Carolina. Accessed January 17, 2021. https://cdr.lib.unc.edu/record/uuid:19a082d1-c0ab-4254-a131-5445a0502aed.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Smith, Austin. “PROTEIN STRUCTURE, STABILITY AND DYNAMICS IN CELLS AND CELL-LIKE ENVIRONMENTS.” 2015. Web. 17 Jan 2021.

Vancouver:

Smith A. PROTEIN STRUCTURE, STABILITY AND DYNAMICS IN CELLS AND CELL-LIKE ENVIRONMENTS. [Internet] [Thesis]. University of North Carolina; 2015. [cited 2021 Jan 17]. Available from: https://cdr.lib.unc.edu/record/uuid:19a082d1-c0ab-4254-a131-5445a0502aed.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Smith A. PROTEIN STRUCTURE, STABILITY AND DYNAMICS IN CELLS AND CELL-LIKE ENVIRONMENTS. [Thesis]. University of North Carolina; 2015. Available from: https://cdr.lib.unc.edu/record/uuid:19a082d1-c0ab-4254-a131-5445a0502aed

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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