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You searched for +publisher:"University of North Carolina" +contributor:("Schools, Zachary"). One record found.

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University of North Carolina

1. Schools, Zachary. Engineering and biophysical analysis of alpha adrenergic receptor crystallography constructs.

Degree: Pharmacology, 2016, University of North Carolina

G protein-coupled receptors (GPCRs) are ubiquitously expressed membrane-spanning proteins that control all of human physiology. GPCRs are structurally complex and their mechanism of activation and signaling is not fully understood. Furthermore, there is a need for more subtype-selective and functionally selective drugs. Development of these drugs could be accelerated by obtaining crystal structures of GPCRs. One such family that could benefit from the structural information in a crystal structure is the Alpha Adrenergic receptors (ADRA). ADRA receptors control cardiovascular as well as peripheral and central nervous system functions, but lack subtype selective drugs. Thus, the ADRA receptor family was screened in parallel for thermostability and likelihood of crystal formation. ADRA1A-nBRIL bound to prazosin was found to be the best target for further crystallization efforts. Advisors/Committee Members: Schools, Zachary, Roth, Bryan, Nicholas, Robert, Graves, Lee.

Subjects/Keywords: School of Medicine; Department of Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Schools, Z. (2016). Engineering and biophysical analysis of alpha adrenergic receptor crystallography constructs. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:5cc29081-8f96-4443-8ee6-f1f839f9a631

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Schools, Zachary. “Engineering and biophysical analysis of alpha adrenergic receptor crystallography constructs.” 2016. Thesis, University of North Carolina. Accessed October 30, 2020. https://cdr.lib.unc.edu/record/uuid:5cc29081-8f96-4443-8ee6-f1f839f9a631.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Schools, Zachary. “Engineering and biophysical analysis of alpha adrenergic receptor crystallography constructs.” 2016. Web. 30 Oct 2020.

Vancouver:

Schools Z. Engineering and biophysical analysis of alpha adrenergic receptor crystallography constructs. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2020 Oct 30]. Available from: https://cdr.lib.unc.edu/record/uuid:5cc29081-8f96-4443-8ee6-f1f839f9a631.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schools Z. Engineering and biophysical analysis of alpha adrenergic receptor crystallography constructs. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:5cc29081-8f96-4443-8ee6-f1f839f9a631

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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