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You searched for +publisher:"University of North Carolina" +contributor:("Roche, Kyle"). One record found.

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University of North Carolina

1. Roche, Kyle. Intrinsic regulation of quiescence and radioresistance in intestinal stem cells.

Degree: Cell Biology and Physiology, 2016, University of North Carolina

The intestinal epithelium regenerates every 5-7 days, a process that is facilitated by a pool of intestinal stem cells. Over the past decade, it has become apparent that the intestinal stem cell pool is diverse, containing at least two populations. Active stem cells (aISCs) are moderately proliferative and contribute to homeostatic regeneration, while reserve stem cells (rISCs) are slowly proliferative and facilitate regeneration following damage-induced loss of the aISC population. The genetic mechanisms required for the production and maintenance of rISCs are unknown. Sox9 is a transcription factor that has been shown to maintain stem cell populations in various tissues. In the intestinal epithelium, Sox9 is expressed in a gradient that negatively correlates with proliferative capacity. Transit-amplifying progenitors express the lowest levels of Sox9, while aISCs express intermediate levels, and cells expressing the highest levels of Sox9 are consistent with slowly cycling rISCs. In this dissertation, I will address the role that Sox9 plays in maintaining rISC function within the intestinal epithelium. I find that Sox9 is not only necessary for the production of a quiescent rISCs, but that it is also uniformly necessary for maintaining radioresistance within the rISC pool. This work identifies Sox9 as a novel intrinsic regulator of the rISC state. Advisors/Committee Members: Roche, Kyle, Otey, Carol, Magness, Scott, Sheikh, Shehzad, Goy, Michael F., Henning, Susan.

Subjects/Keywords: School of Medicine; Department of Cell Biology and Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Roche, K. (2016). Intrinsic regulation of quiescence and radioresistance in intestinal stem cells. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:91534062-64fa-4881-9c13-92b57864f0e7

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Roche, Kyle. “Intrinsic regulation of quiescence and radioresistance in intestinal stem cells.” 2016. Thesis, University of North Carolina. Accessed September 21, 2020. https://cdr.lib.unc.edu/record/uuid:91534062-64fa-4881-9c13-92b57864f0e7.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Roche, Kyle. “Intrinsic regulation of quiescence and radioresistance in intestinal stem cells.” 2016. Web. 21 Sep 2020.

Vancouver:

Roche K. Intrinsic regulation of quiescence and radioresistance in intestinal stem cells. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2020 Sep 21]. Available from: https://cdr.lib.unc.edu/record/uuid:91534062-64fa-4881-9c13-92b57864f0e7.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Roche K. Intrinsic regulation of quiescence and radioresistance in intestinal stem cells. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:91534062-64fa-4881-9c13-92b57864f0e7

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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