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You searched for +publisher:"University of North Carolina" +contributor:("Rebeles, Jennifer"). One record found.

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University of North Carolina

1. Rebeles, Jennifer. Influenza-Specific T Cell Memory: Influenza of Obesity, Weight Loss, Weight Gain.

Degree: Nutrition, 2017, University of North Carolina

Obesity is a global epidemic, with 10% of men and 14% of women obese worldwide. Obesity is a known risk factor for increased complications and death from infection with influenza virus, and impairs the T cell response to both influenza infection and vaccination. As obesity is primarily a metabolic disorder, and immune cell function is dictated by metabolism of the immune cell, the effect of obesity on memory T cell metabolism following a secondary influenza infection was investigated. This dissertation addressed whether the metabolic environment at the time of memory T cell generation or at the time of re-challenge would influence T cell metabolism and function. C57BL/6J high fat diet-induced obese mice were infected with X-31 influenza virus to generate memory T cells, then switched to a low-fat diet to induce weight loss. Following weight loss and normalized fasting glucose levels, mice were re-infected with influenza Puerto Rico/8/34 (PR8) to activate the memory T cells in a newly generated lean state. Conversely, lean mice were infected with X-31 to generate memory T cells followed by a diet switch to a high fat diet to induce obesity. Following weight gain and elevated fasting glucose levels, mice were re-exposed to PR8. Compared with mice that were always lean, mice that were obese for both primary and secondary influenza infections had impaired T cell metabolism and function. Mice that lost weight maintained a metabolic phenotype that paralleled the always obese metabolic phenotype along with dysregulated frequencies of central memory, effector memory, and tissue resident memory T cell populations and decreased function of influenza-specific memory T cell subsets. Mice that had gained weight, and were previously lean, maintained a metabolic profile similar to the mice that were always lean, although also had T cell subset alterations and diminished function. Altogether, this data demonstrates that metabolic environment present at the time of memory T cell generation and at time of secondary immune challenge both impact T cell function. For the first time, obesity has been shown to alter T cell metabolism, and we demonstrate that weight loss will not restore T cell metabolism or function. Advisors/Committee Members: Rebeles, Jennifer, Beck, Melinda A., Coleman, Rosalind, Makowski, Liza, Whitmire, Jason, Hursting, Stephen, University of North Carolina at Chapel Hill.

Subjects/Keywords: Gillings School of Global Public Health; Department of Nutrition

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APA (6th Edition):

Rebeles, J. (2017). Influenza-Specific T Cell Memory: Influenza of Obesity, Weight Loss, Weight Gain. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:73d6b8d2-f8ec-4a04-b491-9c75e26d6b55

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Rebeles, Jennifer. “Influenza-Specific T Cell Memory: Influenza of Obesity, Weight Loss, Weight Gain.” 2017. Thesis, University of North Carolina. Accessed December 04, 2020. https://cdr.lib.unc.edu/record/uuid:73d6b8d2-f8ec-4a04-b491-9c75e26d6b55.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Rebeles, Jennifer. “Influenza-Specific T Cell Memory: Influenza of Obesity, Weight Loss, Weight Gain.” 2017. Web. 04 Dec 2020.

Vancouver:

Rebeles J. Influenza-Specific T Cell Memory: Influenza of Obesity, Weight Loss, Weight Gain. [Internet] [Thesis]. University of North Carolina; 2017. [cited 2020 Dec 04]. Available from: https://cdr.lib.unc.edu/record/uuid:73d6b8d2-f8ec-4a04-b491-9c75e26d6b55.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rebeles J. Influenza-Specific T Cell Memory: Influenza of Obesity, Weight Loss, Weight Gain. [Thesis]. University of North Carolina; 2017. Available from: https://cdr.lib.unc.edu/record/uuid:73d6b8d2-f8ec-4a04-b491-9c75e26d6b55

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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