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You searched for +publisher:"University of North Carolina" +contributor:("Nwachukwu, Kala"). One record found.

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University of North Carolina

1. Nwachukwu, Kala. THE EFFECTS OF IONS ON MUCIN RHEOLOGY AND ORGANIZATION.

Degree: Cell Biology and Physiology, 2016, University of North Carolina

Increased mucus thickness is a common symptom of pulmonary diseases, such as cystic fibrosis (CF) and also occurs in chronic cigarette smokers. The thickening of the mucus layer is caused by a defect in cystic fibrosis transmembrane conductance regulator (CFTR), which causes an imbalance of ion transport, leading to reduced CFTR mediated Cl- dehydrated mucus layer, and poor mucociliary clearance. Here, we present data demonstrating the effects of ions that play a role in mucus layer homeostasis and their effects on mucin composition and rheology. We demonstrate that extracellular CaCl2 increases complex mucin viscosity, while MgCl2 has no effect. Furthermore, we show that HCO3- and pH effect mucin rheology, whereas lower pH and higher concentrated HCO3- results in a higher complex viscosity. While the influence of CaCl2 is not currently known, our data suggest that in excess it may contribute to the viscoelastic properties of mucus. Advisors/Committee Members: Nwachukwu, Kala, Tarran, Robert, Hill, David, Otey, Carol, Cheney, Richard.

Subjects/Keywords: School of Medicine; Department of Cell Biology and Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Nwachukwu, K. (2016). THE EFFECTS OF IONS ON MUCIN RHEOLOGY AND ORGANIZATION. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:d9e560a1-8e85-4e18-9651-cb8d998f022e

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Nwachukwu, Kala. “THE EFFECTS OF IONS ON MUCIN RHEOLOGY AND ORGANIZATION.” 2016. Thesis, University of North Carolina. Accessed September 25, 2020. https://cdr.lib.unc.edu/record/uuid:d9e560a1-8e85-4e18-9651-cb8d998f022e.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Nwachukwu, Kala. “THE EFFECTS OF IONS ON MUCIN RHEOLOGY AND ORGANIZATION.” 2016. Web. 25 Sep 2020.

Vancouver:

Nwachukwu K. THE EFFECTS OF IONS ON MUCIN RHEOLOGY AND ORGANIZATION. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2020 Sep 25]. Available from: https://cdr.lib.unc.edu/record/uuid:d9e560a1-8e85-4e18-9651-cb8d998f022e.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nwachukwu K. THE EFFECTS OF IONS ON MUCIN RHEOLOGY AND ORGANIZATION. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:d9e560a1-8e85-4e18-9651-cb8d998f022e

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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