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You searched for +publisher:"University of North Carolina" +contributor:("McCormick, Maggie"). One record found.

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University of North Carolina

1. McCormick, Maggie. The adhesion molecule PECAM-1 directs endothelial nitric oxide synthase activity and cardiac function to regulate cardiovascular homeostasis.

Degree: Cell Biology and Physiology, 2012, University of North Carolina

The mammalian vascular system is integral to the regulation of homeostasis within an organism. This system is composed of a vast network of blood vessels that transport oxygen and nutrients throughout the body. Blood vessels are lined by endothelial cells (ECs) that provide an interface between circulating blood and the underlying tissue. Based on their unique location, it is unsurprising that ECs are master regulators of numerous physiological processes. ECs are equipped with receptors that interact with their surrounding environment. Among these molecules is Platelet Endothelial Cell Adhesion Molecule-1, or PECAM-1. Since its identification in the early 1990s, PECAM-1 has gained increasing attention for its multi-faceted roles in vascular biology. In this dissertation, I describe two novel roles for PECAM-1 which advance our understanding for how this receptor regulates EC signaling and function. One of the most important cellular signaling molecules in the vasculature is nitric oxide (NO) generated by the enzyme endothelial nitric oxide synthase (eNOS). NO is required for vasodilation and maintenance of the endothelium. Reduced NO production can lead to endothelial dysfunction, the first step in a host of diseases, including atherosclerosis (hardening of the arteries). Previous studies have suggested a role for PECAM-1 in regulating eNOS activity and NO production. Here, I define a pathway by which PECAM-1 regulates the expression of a trafficking protein that influences eNOS localization and activity. In the second half of my dissertation, I focus in vivo using wild type and PECAM-1-/- mice. Our lab has shown that PECAM-1-mediated signaling facilitates activation and expression of molecules that participate in cellular crosstalk. Furthermore, it is well documented that cell crosstalk is central to proper cardiac function. Therefore, we hypothesized that genetic deletion of PECAM-1 may have deleterious effects on heart function. In agreement with this hypothesis, we are the first group to report that PECAM-1-/- mice display dilated cardiomyopathy. Work described in this dissertation defines the mechanism leading to these defects in function. Taken together, the work presented in this thesis further expands the evolving roles of PECAM-1 in cardiovascular biology and provides novel insight to its role in regulating organ function. Advisors/Committee Members: McCormick, Maggie, Otey, Carol.

Subjects/Keywords: School of Medicine; Department of Cell Biology and Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

McCormick, M. (2012). The adhesion molecule PECAM-1 directs endothelial nitric oxide synthase activity and cardiac function to regulate cardiovascular homeostasis. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:958d3e25-0f53-41fd-ab09-99818c8657c9

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

McCormick, Maggie. “The adhesion molecule PECAM-1 directs endothelial nitric oxide synthase activity and cardiac function to regulate cardiovascular homeostasis.” 2012. Thesis, University of North Carolina. Accessed September 25, 2020. https://cdr.lib.unc.edu/record/uuid:958d3e25-0f53-41fd-ab09-99818c8657c9.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

McCormick, Maggie. “The adhesion molecule PECAM-1 directs endothelial nitric oxide synthase activity and cardiac function to regulate cardiovascular homeostasis.” 2012. Web. 25 Sep 2020.

Vancouver:

McCormick M. The adhesion molecule PECAM-1 directs endothelial nitric oxide synthase activity and cardiac function to regulate cardiovascular homeostasis. [Internet] [Thesis]. University of North Carolina; 2012. [cited 2020 Sep 25]. Available from: https://cdr.lib.unc.edu/record/uuid:958d3e25-0f53-41fd-ab09-99818c8657c9.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McCormick M. The adhesion molecule PECAM-1 directs endothelial nitric oxide synthase activity and cardiac function to regulate cardiovascular homeostasis. [Thesis]. University of North Carolina; 2012. Available from: https://cdr.lib.unc.edu/record/uuid:958d3e25-0f53-41fd-ab09-99818c8657c9

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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