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You searched for +publisher:"University of North Carolina" +contributor:("Lin, Lin"). Showing records 1 – 3 of 3 total matches.

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University of North Carolina

1. Lin, Lin. Characterization of the Water Transport Properties of the Active Layers of Polyamide Reverse Osmosis and Nanofiltration Membranes.

Degree: Environmental Sciences and Engineering, 2015, University of North Carolina

The overall objective of this study was to elucidate which parameter among water partitioning, water diffusion and active layer thickness accounts for the differences in water permeability among polyamide reverse osmosis (RO) and nanofiltration (NF) membranes. To achieve this overall objective, the following specific objectives were pursued: (i) to identify appropriate methods (facile and accurate) for measuring active layer thickness in RO/NF membranes; (ii) to ascertain the existence of voids within the polyamide active layers of RO/NF membranes and develop methods to quantify void volume fraction in active layers; (iii) to measure the partition coefficient of water into membrane active layers, and calculate the diffusion coefficient of water in active layers based on measurements of membrane water permeability (A), active layer thickness (δ), and water partition coefficient (K); and (iv) to correlate membrane water permeability (A) to active layer thickness (δ), water partition coefficient (K) and water diffusion coefficient (D) for a group of polyamide RO/NF membranes with a broad range of performance levels. The following major conclusions were drawn through this dissertation: (i) atomic force microscopy (AFM), Rutherford backscattering spectrometry (RBS), quartz crystal microbalance (QCM), profilometry and ellipsometry produce consistent active layer thickness results among each other and likely provide the most accurate results of active layer thickness of RO/NF membranes; (ii) scanning electron microscopy (SEM) and transmission electron microscopy (TEM) likely overestimate active layer thickness; (iii) voids with sizes in the ≈10-100 nm range commonly exist in the active layers of RO/NF membranes, occupy a significant volume fraction of the active layers, and are filled with water when the membranes are in contact with water (e.g., when they are being used for water purification); (iii) among active layer thickness, water partition coefficient and water diffusion coefficient, the differences in water permeabilities among RO/NF membranes were mostly accounted for by the differences in the water diffusion coefficients in their active layers; (iv) the presence of the voids in the active layer increases the membrane water permeance; and (v) there was not a clear correlation between void volume fraction and water permeance, water partition coefficient or water diffusion coefficient. Advisors/Committee Members: Lin, Lin, Coronell, Orlando, Aitken, Michael, Characklis, Gregory, Clegg, Thomas, Dewan, Prasun, Lopez, Rene.

Subjects/Keywords: Environmental engineering; Environmental sciences; Gillings School of Global Public Health; Department of Environmental Sciences and Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lin, L. (2015). Characterization of the Water Transport Properties of the Active Layers of Polyamide Reverse Osmosis and Nanofiltration Membranes. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:8ead5fe9-6886-4daf-a5c3-79c7eac2c91b

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lin, Lin. “Characterization of the Water Transport Properties of the Active Layers of Polyamide Reverse Osmosis and Nanofiltration Membranes.” 2015. Thesis, University of North Carolina. Accessed March 09, 2021. https://cdr.lib.unc.edu/record/uuid:8ead5fe9-6886-4daf-a5c3-79c7eac2c91b.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lin, Lin. “Characterization of the Water Transport Properties of the Active Layers of Polyamide Reverse Osmosis and Nanofiltration Membranes.” 2015. Web. 09 Mar 2021.

Vancouver:

Lin L. Characterization of the Water Transport Properties of the Active Layers of Polyamide Reverse Osmosis and Nanofiltration Membranes. [Internet] [Thesis]. University of North Carolina; 2015. [cited 2021 Mar 09]. Available from: https://cdr.lib.unc.edu/record/uuid:8ead5fe9-6886-4daf-a5c3-79c7eac2c91b.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin L. Characterization of the Water Transport Properties of the Active Layers of Polyamide Reverse Osmosis and Nanofiltration Membranes. [Thesis]. University of North Carolina; 2015. Available from: https://cdr.lib.unc.edu/record/uuid:8ead5fe9-6886-4daf-a5c3-79c7eac2c91b

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of North Carolina

2. Lin, Lin. THE ROLE OF BP180 IN GRANULOPOIESIS AND NLRP3 INFLAMMASOME ACTIVATION IN BULLOUS PEMPHIGOID.

Degree: 2016, University of North Carolina

BP180 (also called collagen XVII) is a hemidesmosomal protein. Autoantibodies directly against it cause bullous pemphigoid (BP). Gene mutations of BP180 result in generalized atrophic benign epidermolysis bullosa (GABEB). BP patients’ autoantibodies primarily recognize NC16A domain of BP180; however, there is no cross reactivity between human NC16A and mouse homologue termed NC14A. To investigate the pathogenesis of BP and identify new functions of BP180, we established humanized BP180NC16A (NC16A) mice, and subsequently NC16A domain truncated (ΔNC16A) mice. In ΔNC16A mice, we discovered a novel function of BP180: this cell-matrix adhesion molecule may work on a signaling pathway regulating granulopoiesis. It was recently reported that GABEB or other types of epidermolysis bullosa (EB) patients have granulocyte infiltration and eosinophilia. Abnormal granulopoiesis was also observed in ΔNC16A mice in addition to skin abnormality. The affected granulopoiesis originated in the stromal cell compartment of the bone marrow because transplantation of bone marrow from ΔNC16 mice into wild-type mice corrected the myeloid hyperplasia. In addition, ΔNC16 mice at 4 weeks of age also developed myeloid hyperplasia without any skin lesions. K14 Cre-driven, skin-specific ΔNC16 mice exhibit similar skin lesions as ΔNC16A mice, but had normal granulopoiesis. We demonstrated that NC16A deletion induces NF-kB signaling pathway activation that leads to elevated G-CSF secretion in bone marrow and blood. G-CSF regulates granulopoiesis in bone marrow. These findings provide a mechanism for clinical relevant pathophysiological observation in BP and Junctional Epidermolysis Bullosa (JEB). NC16A mice injected with anti-NC16A autoantibodies develop skin disease that closely mimics the clinical, immunological and histological features of human BP. Previous works have shown that pathological autoantibodies against NC16A, when binding to the target on basal keratinocytes, trigger complement activation to generate C5a. C5a binding to the C5a receptor on mast cells leads to TNFα release. Mast cell recruitment of polymorphonuclear neutrophils is required for disease. However, the mechanisms by which mast cells recruit neutrophils to the antibody-binding sites are not completely known. We used mice lacking key components of NLRP’s inflammasome to test whether mast cell-released TNF-α would act on keratinocyte as first signal and pathogenic IgG binding to BP180 as a second signal to activate NLRP3 inflammasome in basal keratinocyte. We found that pathogenic antibody-induced BP depends on NLRP3 activation, leading to IL-1β release and subsequent neutrophil recruitment. Furthermore, we showed that IL-1R antagonist, Anakinra, could be an effective drug to treat experimental BP. In this study, we suggest a molecular mechanism for mast cells recruitment of neutrophils in experimental BP. More importantly, our findings identify potential new therapeutic targets for treatment of BP. The findings described in this dissertation explored a novel function of… Advisors/Committee Members: Lin, Lin, Liu, Zhi, Arnold, Roland, Miao, Edward, Ting, Jenny P.-Y., Vilen, Barbara J., Liu, Zhi.

Subjects/Keywords: School of Dentistry; Oral and Craniofacial Biomedicine PhD Program

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lin, L. (2016). THE ROLE OF BP180 IN GRANULOPOIESIS AND NLRP3 INFLAMMASOME ACTIVATION IN BULLOUS PEMPHIGOID. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:e1e4c123-fc53-47cd-8b49-b71d2aee62d3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lin, Lin. “THE ROLE OF BP180 IN GRANULOPOIESIS AND NLRP3 INFLAMMASOME ACTIVATION IN BULLOUS PEMPHIGOID.” 2016. Thesis, University of North Carolina. Accessed March 09, 2021. https://cdr.lib.unc.edu/record/uuid:e1e4c123-fc53-47cd-8b49-b71d2aee62d3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lin, Lin. “THE ROLE OF BP180 IN GRANULOPOIESIS AND NLRP3 INFLAMMASOME ACTIVATION IN BULLOUS PEMPHIGOID.” 2016. Web. 09 Mar 2021.

Vancouver:

Lin L. THE ROLE OF BP180 IN GRANULOPOIESIS AND NLRP3 INFLAMMASOME ACTIVATION IN BULLOUS PEMPHIGOID. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2021 Mar 09]. Available from: https://cdr.lib.unc.edu/record/uuid:e1e4c123-fc53-47cd-8b49-b71d2aee62d3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin L. THE ROLE OF BP180 IN GRANULOPOIESIS AND NLRP3 INFLAMMASOME ACTIVATION IN BULLOUS PEMPHIGOID. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:e1e4c123-fc53-47cd-8b49-b71d2aee62d3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of North Carolina

3. Lin, Lin. Living with uncertainty: the psychological adjustment and coping by parents of children with cancer in Taiwan.

Degree: 2007, University of North Carolina

The prognoses of childhood cancers have improved over the last few decades. Nevertheless, parental uncertainty about the absolute cure and possible relapse pervades the entire illness trajectory. The perception of uncertainty has been previously identified as a significant factor correlating to psychological distress. The influence of coping processes on psychological outcomes in parents of children with cancer has not been investigated vigorously. The continual uncertainty may serve as a catalyst for positive psychological changes and personal growth especially in the context of chronic illnesses. The purpose of this study was to develop and examine a conceptual model depicting the psychological adjustment and coping of Taiwanese parents by living with continual uncertainty about their child's cancer. This study was a secondary data analysis of 205 mothers and 96 fathers of 226 children who had been diagnosed with cancer in Taiwan. A cross-sectional design was utilized to examine the relationships among proposed variables. Some variables were measured by culturally sensitive instruments developed in Taiwan. The proposed alternative models fit adequately to the data via structural equation modeling tests. Parental uncertainty was directly correlated to psychological distress whereas parents' perceived social support and coping did not mediate the relationship between parental uncertainty and psychological distress. However, parental uncertainty and parents' perceived social support were associated with psychological growth mediated by parents' coping such as interacting with families and maintaining an optimistic state of mind. Based on the current research findings, reducing illness-related uncertainty may decrease psychological distress directly and increase psychological growth indirectly though more coping in Taiwanese parents of children with cancer. Furthermore, perceived social support did not directly help parents to reduce psychological distress or increase psychological growth. However, the availability of social support may improve the reduction of psychological distress by lowering parental uncertainty and increase psychological growth by lowering parental uncertainty and encouraging more coping. The psychological adjustment of Taiwanese parents to childhood cancer has effectively conceptualized by the adaptation of Mishel's (1998, 1990) Uncertainty in Illness Theory and Reconceptualization of Uncertainty in Illness Theory as shown in the present study. The findings may provide possible guidelines for nurses in delivering a more competent health care for Taiwanese parents of children with cancer. Advisors/Committee Members: Lin, Lin, Mishel, Merle H..

Subjects/Keywords: School of Nursing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lin, L. (2007). Living with uncertainty: the psychological adjustment and coping by parents of children with cancer in Taiwan. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:76f7436e-0db1-4643-b1c9-092182d11508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lin, Lin. “Living with uncertainty: the psychological adjustment and coping by parents of children with cancer in Taiwan.” 2007. Thesis, University of North Carolina. Accessed March 09, 2021. https://cdr.lib.unc.edu/record/uuid:76f7436e-0db1-4643-b1c9-092182d11508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lin, Lin. “Living with uncertainty: the psychological adjustment and coping by parents of children with cancer in Taiwan.” 2007. Web. 09 Mar 2021.

Vancouver:

Lin L. Living with uncertainty: the psychological adjustment and coping by parents of children with cancer in Taiwan. [Internet] [Thesis]. University of North Carolina; 2007. [cited 2021 Mar 09]. Available from: https://cdr.lib.unc.edu/record/uuid:76f7436e-0db1-4643-b1c9-092182d11508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin L. Living with uncertainty: the psychological adjustment and coping by parents of children with cancer in Taiwan. [Thesis]. University of North Carolina; 2007. Available from: https://cdr.lib.unc.edu/record/uuid:76f7436e-0db1-4643-b1c9-092182d11508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.