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You searched for +publisher:"University of North Carolina" +contributor:("Lessey-Morillon, Elizabeth"). One record found.

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University of North Carolina

1. Lessey-Morillon, Elizabeth. The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction In Endothelial Cells To Stimulate Transendothelial Migration.

Degree: Cell Biology and Physiology, 2014, University of North Carolina

RhoA-mediated cytoskeletal rearrangements in endothelial cells (ECs) play an active role in leukocyte transendothelial cell migration (TEM), a normal physiological process in which leukocytes cross the endothelium to enter the underlying tissue. While much has been learned about RhoA signaling pathways downstream from ICAM-1 in ECs, little is known about the consequences of the tractional forces that leukocytes generate on ECs as they migrate over the surface before TEM. We have found that after applying mechanical forces to ICAM-1 clusters, there is an increase in cellular stiffening and enhanced RhoA signaling compared to ICAM-1 clustering alone. We have identified that the Rho GEF LARG/ARHGEF12 acts downstream of clustered ICAM-1 to increase RhoA activity and that this pathway is further enhanced by mechanical force on ICAM-1. Depletion of LARG decreases leukocyte crawling and inhibits TEM. This is the first report of endothelial LARG regulating leukocyte behavior and EC stiffening in response to tractional forces generated by leukocytes. Advisors/Committee Members: Lessey-Morillon, Elizabeth, Burridge, Keith, Bear, James, Doerschuk, Claire, Major, Ben, Tzima, Eleni.

Subjects/Keywords: Cytology; School of Medicine; Department of Cell Biology and Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lessey-Morillon, E. (2014). The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction In Endothelial Cells To Stimulate Transendothelial Migration. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:e0425b15-91e2-46a9-aead-d82aee48dc8b

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lessey-Morillon, Elizabeth. “The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction In Endothelial Cells To Stimulate Transendothelial Migration.” 2014. Thesis, University of North Carolina. Accessed October 28, 2020. https://cdr.lib.unc.edu/record/uuid:e0425b15-91e2-46a9-aead-d82aee48dc8b.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lessey-Morillon, Elizabeth. “The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction In Endothelial Cells To Stimulate Transendothelial Migration.” 2014. Web. 28 Oct 2020.

Vancouver:

Lessey-Morillon E. The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction In Endothelial Cells To Stimulate Transendothelial Migration. [Internet] [Thesis]. University of North Carolina; 2014. [cited 2020 Oct 28]. Available from: https://cdr.lib.unc.edu/record/uuid:e0425b15-91e2-46a9-aead-d82aee48dc8b.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lessey-Morillon E. The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction In Endothelial Cells To Stimulate Transendothelial Migration. [Thesis]. University of North Carolina; 2014. Available from: https://cdr.lib.unc.edu/record/uuid:e0425b15-91e2-46a9-aead-d82aee48dc8b

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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