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You searched for +publisher:"University of North Carolina" +contributor:("Klett, Eric"). Showing records 1 – 2 of 2 total matches.

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University of North Carolina

1. Dong, Sharlene. Epigenetic regulation of murine Stab2 expression in determining atherosclerotic susceptibility.

Degree: Nutrition, 2017, University of North Carolina

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries. In mice, the aortic arch and root show distinct patterns of lesion development. A quantitative trait locus (QTL) analysis of an intercross between apoE-null mice on 129S6 and DBA/2J backgrounds has revealed a significant locus on chromosome 10, Aath5, that affects plaque size in the arch. One candidate gene in the Aath5 locus is the Stab2 gene, which encodes a receptor for hyaluronan. The DBA allele of the Stab2 gene includes a unique intracisternal A-particle (IAP) retrotransposon inserted in reverse in the promoter region, which drives Stab2 expression. Methylation status of this region was analyzed through allele-specific bisulfite sequencing and correlated with ectopic Stab2 expression in the heart and kidneys. Thus, epigenetic regulation of this IAP element may play a role in regulating Stab2 expression and affect atherosclerotic susceptibility in the aortic arch. Advisors/Committee Members: Dong, Sharlene, Maeda, Nobuyo, Coleman, Rosalind, Klett, Eric.

Subjects/Keywords: Gillings School of Global Public Health; Department of Nutrition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Dong, S. (2017). Epigenetic regulation of murine Stab2 expression in determining atherosclerotic susceptibility. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:67d29a0e-cc10-47d3-af08-55b198b0bd78

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Dong, Sharlene. “Epigenetic regulation of murine Stab2 expression in determining atherosclerotic susceptibility.” 2017. Thesis, University of North Carolina. Accessed October 31, 2020. https://cdr.lib.unc.edu/record/uuid:67d29a0e-cc10-47d3-af08-55b198b0bd78.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Dong, Sharlene. “Epigenetic regulation of murine Stab2 expression in determining atherosclerotic susceptibility.” 2017. Web. 31 Oct 2020.

Vancouver:

Dong S. Epigenetic regulation of murine Stab2 expression in determining atherosclerotic susceptibility. [Internet] [Thesis]. University of North Carolina; 2017. [cited 2020 Oct 31]. Available from: https://cdr.lib.unc.edu/record/uuid:67d29a0e-cc10-47d3-af08-55b198b0bd78.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dong S. Epigenetic regulation of murine Stab2 expression in determining atherosclerotic susceptibility. [Thesis]. University of North Carolina; 2017. Available from: https://cdr.lib.unc.edu/record/uuid:67d29a0e-cc10-47d3-af08-55b198b0bd78

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of North Carolina

2. Cooper, Daniel. Physiological Consequences of Compartmentalized Glycerolipid Synthesis.

Degree: Nutrition, 2015, University of North Carolina

The metabolic derangements present in type 2 diabetes are associated with the accumulation of triacylglycerol (TAG) in adipose and non-adipose tissues. However, the mechanisms whereby TAG accumulation drives pathogenesis remain obscure. The synthesis of TAG and other glycerolipids is initiated by the rate-limiting enzyme, glycerol-3-phosphate acyltransferase (GPAT), which catalyzes the esterification of an acyl-CoA to the sn-1 position of the glycerol-3-phosphate backbone. Four mammalian GPAT isoforms, each the product of a separate gene, have been discovered and recent evidence suggests that each GPAT isoform performs a unique function in directing glycerolipid synthesis. To test this hypothesis, we investigated the role of different GPAT isoforms in liver and brown adipose lipid metabolism, and adipocyte differentiation. First, we compared the unique functions of the major hepatic GPAT isoforms, GPAT1 and GPAT4. Although these isoforms contribute a similar amount of total GPAT activity in liver, GPAT1, but not GPAT4, was required for the incorporation of de novo synthesized fatty acids (FA) into TAG and to divert FA away from β-oxidation. Next, we elucidated the mechanism whereby mice lacking GPAT4 are protected from diet-induced obesity. GPAT4 is a major GPAT isoform in BAT, comprising approximately 65% of the total GPAT activity. In primary brown adipocytes lacking GPAT4 exogenous oleate was oxidized at a 46% higher rate than controls, suggesting that Gpat4-/- mice are protected from diet-induced obesity because GPAT4 in brown adipose tissue is required to limit the oxidation of exogenous FA. Finally, we provide evidence that the lipodystrophy-associated protein Seipin is an evolutionarily conserved regulator of GPAT activity. Seipin and its yeast ortholog, Fld1, physically interacted with GPAT and the loss of Seipin was associated with increased GPAT activity because GPAT had a higher affinity for one of its substrates, glycerol-3-phosphate. Seipin deficiency impairs adipogenesis and alters lipid droplet morphology and in 3T3L1 preadipocytes, GPAT overexpression recapitulated these effects, suggesting that increased GPAT activity is the underlying cause of the impaired adipogenesis and altered lipid droplet morphology. Taken together, these results suggest that the functions of each GPAT isoform are linked to specific physiological processes and that glycerolipid synthesis is highly compartmentalized. Advisors/Committee Members: Cooper, Daniel, Coleman, Rosalind, Klett, Eric, Lund, Pauline Kay, Makowski, Liza, Hursting, Stephen.

Subjects/Keywords: Biochemistry; Nutrition; Gillings School of Global Public Health; Department of Nutrition

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Cooper, D. (2015). Physiological Consequences of Compartmentalized Glycerolipid Synthesis. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:cdb988ba-d01d-4e5c-8693-fedec95fa5c1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Cooper, Daniel. “Physiological Consequences of Compartmentalized Glycerolipid Synthesis.” 2015. Thesis, University of North Carolina. Accessed October 31, 2020. https://cdr.lib.unc.edu/record/uuid:cdb988ba-d01d-4e5c-8693-fedec95fa5c1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Cooper, Daniel. “Physiological Consequences of Compartmentalized Glycerolipid Synthesis.” 2015. Web. 31 Oct 2020.

Vancouver:

Cooper D. Physiological Consequences of Compartmentalized Glycerolipid Synthesis. [Internet] [Thesis]. University of North Carolina; 2015. [cited 2020 Oct 31]. Available from: https://cdr.lib.unc.edu/record/uuid:cdb988ba-d01d-4e5c-8693-fedec95fa5c1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cooper D. Physiological Consequences of Compartmentalized Glycerolipid Synthesis. [Thesis]. University of North Carolina; 2015. Available from: https://cdr.lib.unc.edu/record/uuid:cdb988ba-d01d-4e5c-8693-fedec95fa5c1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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