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You searched for +publisher:"University of North Carolina" +contributor:("Kay Lund, Pauline Kay"). One record found.

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University of North Carolina

1. Freeman, Leslie. A Role for the NLR Family Members NLRC4 And NLRP3 in Astrocytic Inflammasome Activation and Astrogliosis.

Degree: 2016, University of North Carolina

The inflammasome is implicated in many inflammatory diseases but has been primarily studied in the macrophage-myeloid lineage. Here we demonstrate a physiologic role for nucleotide-binding domain, leucine-rich repeat, CARD domain containing 4 (NLRC4) in brain astrocytes. NLRC4 has been primarily studied in the context of gram-negative bacteria, where it is required for the maturation of pro-caspase-1 to active caspase-1. We show the heightened expression of NLRC4 protein in astrocytes in a cuprizone model of neuroinflammation and demyelination as well as human multiple sclerotic brains. Similar to macrophages, NLRC4 in astrocytes is required for inflammasome activation by its known agonist, flagellin. However, NLRC4 in astrocytes also mediate inflammasome activation in response to lysophosphatidylcholine (LPC), an inflammatory molecule associated with neurologic disorders. In addition to NLRC4, astrocytic NLRP3 is required for inflammasome activation by LPC. Two biochemical assays show the interaction of NLRC4 with NLRP3, suggesting the possibility of a NLRC4-NLRP3 co-inflammasome. Advisors/Committee Members: Freeman, Leslie, Ting, Jenny P.-Y., Matsushima, Glenn, Koller, Beverly H., Markovic-Plese, Silva, Kay Lund, Pauline Kay.

Subjects/Keywords: School of Medicine; Curriculum in Genetics and Molecular Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Freeman, L. (2016). A Role for the NLR Family Members NLRC4 And NLRP3 in Astrocytic Inflammasome Activation and Astrogliosis. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:ec028a13-7c5a-41ed-af8d-3b5a5865278d

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Freeman, Leslie. “A Role for the NLR Family Members NLRC4 And NLRP3 in Astrocytic Inflammasome Activation and Astrogliosis.” 2016. Thesis, University of North Carolina. Accessed October 31, 2020. https://cdr.lib.unc.edu/record/uuid:ec028a13-7c5a-41ed-af8d-3b5a5865278d.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Freeman, Leslie. “A Role for the NLR Family Members NLRC4 And NLRP3 in Astrocytic Inflammasome Activation and Astrogliosis.” 2016. Web. 31 Oct 2020.

Vancouver:

Freeman L. A Role for the NLR Family Members NLRC4 And NLRP3 in Astrocytic Inflammasome Activation and Astrogliosis. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2020 Oct 31]. Available from: https://cdr.lib.unc.edu/record/uuid:ec028a13-7c5a-41ed-af8d-3b5a5865278d.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Freeman L. A Role for the NLR Family Members NLRC4 And NLRP3 in Astrocytic Inflammasome Activation and Astrogliosis. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:ec028a13-7c5a-41ed-af8d-3b5a5865278d

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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