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University of North Carolina

1. Hsia, Hung-Ching. ROLES AND REGULATION OF STAT3 IN INNATE IMMUNITY.

Degree: Cell Biology and Physiology, 2017, University of North Carolina

Innate immunity is the first line of host defense to microbial infections. The rapid induction of the innate immune response is achieved through recognition of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). Upon recognition of PAMPs and DAMPs, cells initiate immune responses by expressing type I interferons (IFN) and interferon-stimulated genes (ISGs) to establish an antiviral and antimicrobial state, and by secreting cytokines and chemokines to recruit and activate immune cells such as macrophages and monocytes. These processes are precisely regulated to initiate a swift and effective defense against pathogens. My dissertation focuses on the roles and regulation of signal transducer and activator of transcription 3 (STAT3) in these responses. In the first project, I investigated the role of STAT3 in myeloid cells with regards to innate immune responses during viral infection. We discovered that STAT3 knockout mice are more susceptible to herpes simplex virus-1 (HSV-1) due to an attenuated IFN response and to defects in dendritic cell and natural killer cell activation, revealing a requirement of STAT3 in eliciting an effective innate immune response against HSV-1. The second project focused on dissecting the signaling pathways activated by cytosolic DNA, a DAMP, and the regulation of downstream transcription factors. I identified a novel signaling axis involving an inhibitory phosphorylation in STAT3 by TANK-binding kinase 1 (TBK1). This TBK1-mediated phosphorylation restricts STAT3 activation and expression of selective STAT3 target genes in response to cytosolic DNA. Collectively, the research presented in this dissertation demonstrates a pivotal role of STAT3 in host innate immunity against viral infection, and uncovers a novel mechanism whereby the activity of STAT3 can be fine-tuned by innate immune response pathways. Advisors/Committee Members: Hsia, Hung-Ching, Baldwin, Albert, Cyr, Douglas, Damania, Blossom, Major, Ben, Xiong, Yue.

Subjects/Keywords: School of Medicine; Department of Cell Biology and Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hsia, H. (2017). ROLES AND REGULATION OF STAT3 IN INNATE IMMUNITY. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:757e9627-ce60-4c50-9567-df37da02c123

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Hsia, Hung-Ching. “ROLES AND REGULATION OF STAT3 IN INNATE IMMUNITY.” 2017. Thesis, University of North Carolina. Accessed September 28, 2020. https://cdr.lib.unc.edu/record/uuid:757e9627-ce60-4c50-9567-df37da02c123.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Hsia, Hung-Ching. “ROLES AND REGULATION OF STAT3 IN INNATE IMMUNITY.” 2017. Web. 28 Sep 2020.

Vancouver:

Hsia H. ROLES AND REGULATION OF STAT3 IN INNATE IMMUNITY. [Internet] [Thesis]. University of North Carolina; 2017. [cited 2020 Sep 28]. Available from: https://cdr.lib.unc.edu/record/uuid:757e9627-ce60-4c50-9567-df37da02c123.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsia H. ROLES AND REGULATION OF STAT3 IN INNATE IMMUNITY. [Thesis]. University of North Carolina; 2017. Available from: https://cdr.lib.unc.edu/record/uuid:757e9627-ce60-4c50-9567-df37da02c123

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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