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You searched for +publisher:"University of North Carolina" +contributor:("Holk, Alicia"). One record found.

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University of North Carolina

1. Holk, Alicia. Investigating novel mechanisms of Translesion Synthesis (TLS) regulation in cancer.

Degree: 2016, University of North Carolina

Cells are subjected to a range of DNA damaging agents from intrinsic, environmental, and therapeutic sources. The ability to cope with DNA damage is essential for maintaining genomic stability and preventing disease. Trans-lesion Synthesis(TLS) is a mechanism by which cells tolerate DNA damage by utilizing flexible, albeit error-prone, polymerases to bypass DNA lesions. Here we show that aberrantly expressed cancer testes antigen, Melanoma-Associated Antigen 4 (MAGE-A4), is a unique regulator of TLS in many neoplastic cells, demonstrating a novel mechanism for both mutagenesis and therapy-resistant cancer. Owing to its role in chemoresistance, TLS represents an appealing pathway for targeted cancer therapies. As an initial step in the drug discovery process we have identified small molecule inhibitors which target the essential interaction between TLS Polymerase Eta and mono-ubiquitinated PCNA. Taken together, we have identified a new mechanism for conferring tumorigenic phenotypes and initiated efforts to target this pathway for therapeutic purposes. Advisors/Committee Members: Holk, Alicia, Vaziri, Cyrus, Sekelsky, Jeff, Ramsden, Dale, Major, Ben.

Subjects/Keywords: School of Medicine; Curriculum in Genetics and Molecular Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Holk, A. (2016). Investigating novel mechanisms of Translesion Synthesis (TLS) regulation in cancer. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:44421fcc-2ffd-4fa1-8288-80a18d51f659

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Holk, Alicia. “Investigating novel mechanisms of Translesion Synthesis (TLS) regulation in cancer.” 2016. Thesis, University of North Carolina. Accessed October 23, 2020. https://cdr.lib.unc.edu/record/uuid:44421fcc-2ffd-4fa1-8288-80a18d51f659.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Holk, Alicia. “Investigating novel mechanisms of Translesion Synthesis (TLS) regulation in cancer.” 2016. Web. 23 Oct 2020.

Vancouver:

Holk A. Investigating novel mechanisms of Translesion Synthesis (TLS) regulation in cancer. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2020 Oct 23]. Available from: https://cdr.lib.unc.edu/record/uuid:44421fcc-2ffd-4fa1-8288-80a18d51f659.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Holk A. Investigating novel mechanisms of Translesion Synthesis (TLS) regulation in cancer. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:44421fcc-2ffd-4fa1-8288-80a18d51f659

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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