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You searched for +publisher:"University of North Carolina" +contributor:("Erickson, Harold"). One record found.

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University of North Carolina

1. Kim, Doo Nam. Computer-based Design of β-sheet Containing Proteins.

Degree: Biochemistry and Biophysics, 2016, University of North Carolina

URL: https://cdr.lib.unc.edu/record/uuid:076f3980-6637-481b-bece-d26ad5cdb96a 

Protein design is an excellent test of the minimal determinants of protein structure. Although 70% of naturally occurring proteins contain β-sheets, most previous design efforts have been limited to α-helix bundle proteins or the redesign of naturally occurring proteins. Here, we test and develop computer based methods for designing proteins rich in β-strands. The molecular modeling program Rosetta was used for three separate design tasks: (1) the design of α/β and α+β proteins with a new method called SEWING, which builds proteins from pieces of naturally occurring proteins, (2) the stabilization of β-sheet proteins via the redesign of surface-facing residues, and (3) the de novo design of β-sandwich proteins. This research showed that it is possible to extend the SEWING method to non-α-helix proteins, allowing the incorporation of structural features found in nature, and that it is possible to dramatically boost protein thermal stability (> 25 °C) with the redesign β-sheet surfaces. However, we also found that the de novo design of β-sandwich proteins still remains an elusive goal. Advisors/Committee Members: Kim, Doo Nam, Kuhlman, Brian, Zhang, Qi, Lee, Andrew, Erickson, Harold, Richardson, Jane.

Subjects/Keywords: School of Medicine; Department of Biochemistry and Biophysics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kim, D. N. (2016). Computer-based Design of β-sheet Containing Proteins. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:076f3980-6637-481b-bece-d26ad5cdb96a

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kim, Doo Nam. “Computer-based Design of β-sheet Containing Proteins.” 2016. Thesis, University of North Carolina. Accessed January 26, 2021. https://cdr.lib.unc.edu/record/uuid:076f3980-6637-481b-bece-d26ad5cdb96a.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kim, Doo Nam. “Computer-based Design of β-sheet Containing Proteins.” 2016. Web. 26 Jan 2021.

Vancouver:

Kim DN. Computer-based Design of β-sheet Containing Proteins. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2021 Jan 26]. Available from: https://cdr.lib.unc.edu/record/uuid:076f3980-6637-481b-bece-d26ad5cdb96a.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim DN. Computer-based Design of β-sheet Containing Proteins. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:076f3980-6637-481b-bece-d26ad5cdb96a

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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