Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"University of North Carolina" +contributor:("Eldridge, Meagan"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of North Carolina

1. Eldridge, Meagan. Identifying biomarkers of response to modified FOLFIRINOX regimens using patient derived xenograft mouse models of pancreatic ductal adenocarcinoma.

Degree: Pharmacology, 2014, University of North Carolina

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited effective therapies. FOLFIRINOX is a chemotherapeutic regimen for patients with metastatic disease that provides an unprecedented median overall survival of 11.1 months. However, significant toxicities necessitate dose reductions and limit the number of patients eligible for FOLFIRINOX treatment. I used patient derived xenograft (PDX) mouse models of PDAC to assess efficacy of modified regimens and determine if intra-tumoral heterogeneity plays a role in response. I also used RNA sequencing of PDX tumors to identify potential biomarkers of response. No significant differences in response to standard and modified FOLFIRINOX regimens were observed; however, intra-tumoral heterogeneity affected responses of one PDX tumor line to modified regimens. Biomarkers associated with differential responses could not be identified by RNA sequencing. RNA sequencing data confirmed previously identified PDAC subtypes, classical and basal-like. Advisors/Committee Members: Eldridge, Meagan, Yeh, Jen Jen, Graves, Lee, Nicholas, Robert.

Subjects/Keywords: Pharmacology; School of Medicine; Department of Pharmacology

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Eldridge, M. (2014). Identifying biomarkers of response to modified FOLFIRINOX regimens using patient derived xenograft mouse models of pancreatic ductal adenocarcinoma. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:53f3ee63-f386-49e8-b5d3-a2569507dc6e

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Eldridge, Meagan. “Identifying biomarkers of response to modified FOLFIRINOX regimens using patient derived xenograft mouse models of pancreatic ductal adenocarcinoma.” 2014. Thesis, University of North Carolina. Accessed October 30, 2020. https://cdr.lib.unc.edu/record/uuid:53f3ee63-f386-49e8-b5d3-a2569507dc6e.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Eldridge, Meagan. “Identifying biomarkers of response to modified FOLFIRINOX regimens using patient derived xenograft mouse models of pancreatic ductal adenocarcinoma.” 2014. Web. 30 Oct 2020.

Vancouver:

Eldridge M. Identifying biomarkers of response to modified FOLFIRINOX regimens using patient derived xenograft mouse models of pancreatic ductal adenocarcinoma. [Internet] [Thesis]. University of North Carolina; 2014. [cited 2020 Oct 30]. Available from: https://cdr.lib.unc.edu/record/uuid:53f3ee63-f386-49e8-b5d3-a2569507dc6e.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Eldridge M. Identifying biomarkers of response to modified FOLFIRINOX regimens using patient derived xenograft mouse models of pancreatic ductal adenocarcinoma. [Thesis]. University of North Carolina; 2014. Available from: https://cdr.lib.unc.edu/record/uuid:53f3ee63-f386-49e8-b5d3-a2569507dc6e

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.