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You searched for +publisher:"University of North Carolina" +contributor:("Dumond, Julie"). Showing records 1 – 2 of 2 total matches.

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University of North Carolina

1. Mellnik, John. Microrheology and Heterogeneity in Biological Fluids: Approaches, Models and Applications.

Degree: 2015, University of North Carolina

Fluids play an important role in a wide range of biological processes. They facilitate cellular activities, protect us from infection and propagate nutrients throughout the body, to name a few. In each case, the properties of the fluid are finely tuned to the task at hand, and understanding those properties can afford a deeper understanding of the underlying biology. Furthermore, knowing how disease or environmental factors alter the properties of these fluids can provide a means to interpret, and forecast, downstream deleterious effects. To this end, microrheology is an increasingly popular means of investigating biological fluids. This technique, whereby tracer particles are embedded in the fluid of interest and their diffusive movements are used to infer the viscous and elastic moduli of the surrounding fluid, offers insight into properties of the fluid at a spatial and temporal resolution unmatched by traditional macrorheology approaches. Despite its benefits, the wider application of microrheology has been limited by the presence of two, frequently encountered, phenomena: the existence of an active driving force coupled to the stochastic movement of the tracer particles, and the presence of spatial, or temporal, heterogeneity in the fluid under investigation. This work proposes best practices for addressing each of these phenomena and demonstrates how they may be coupled to diffusion models to more accurately describe, and predict, the movement of micro- and nano-scale particles through biological fluids. We apply the methodology developed herein to the analysis of bronchoalveolar lavage fluid from a pediatric cystic fibrosis cohort as part of an ongoing effort to characterize pulmonary manifestations of the disease. Advisors/Committee Members: Mellnik, John, Elston, Timothy, Forest, M. Gregory, Dumond, Julie, Gomez, Shawn, Lai, Samuel.

Subjects/Keywords: Mechanics, Applied – Mathematics; School of Medicine; Curriculum in Bioinformatics and Computational Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mellnik, J. (2015). Microrheology and Heterogeneity in Biological Fluids: Approaches, Models and Applications. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:348e164c-ec6f-4a64-9b17-015e82d77fa8

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mellnik, John. “Microrheology and Heterogeneity in Biological Fluids: Approaches, Models and Applications.” 2015. Thesis, University of North Carolina. Accessed November 29, 2020. https://cdr.lib.unc.edu/record/uuid:348e164c-ec6f-4a64-9b17-015e82d77fa8.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mellnik, John. “Microrheology and Heterogeneity in Biological Fluids: Approaches, Models and Applications.” 2015. Web. 29 Nov 2020.

Vancouver:

Mellnik J. Microrheology and Heterogeneity in Biological Fluids: Approaches, Models and Applications. [Internet] [Thesis]. University of North Carolina; 2015. [cited 2020 Nov 29]. Available from: https://cdr.lib.unc.edu/record/uuid:348e164c-ec6f-4a64-9b17-015e82d77fa8.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mellnik J. Microrheology and Heterogeneity in Biological Fluids: Approaches, Models and Applications. [Thesis]. University of North Carolina; 2015. Available from: https://cdr.lib.unc.edu/record/uuid:348e164c-ec6f-4a64-9b17-015e82d77fa8

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of North Carolina

2. Watt, Kevin. Physiologically-based Pharmacokinetics in Critically Ill Children.

Degree: 2016, University of North Carolina

Extracorporeal membrane oxygenation (ECMO) is used to support cardiorespiratory failure in critically ill infants, children, and adults. In these vulnerable populations, the effect of ECMO on drug disposition leaves clinicians with uncertainty about dosing. The goal of this dissertation research was to develop a physiologically-based pharmacokinetic (PBPK) modeling approach that translated results from ex vivo ECMO studies to bedside dosing recommendations. To determine optimal dosing, the impact of the ECMO circuit on antifungal disposition was first assessed in isolation through ex vivo studies of three antifungal drugs. These experiments showed variable degrees of extraction by the ECMO circuit with micafungin highly extracted and fluconazole and amphotericin B deoxycholate with limited extraction. These results were then used to parameterize drug-specific ECMO compartments in the PBPK models. Model building followed an established workflow whereby a PBPK model was developed in adults and scaled to children. Once the Pediatric PBPK Model met acceptance criteria, an ECMO compartment was added to the Pediatric PBPK Model to form the ECMO PBPK Model. The fluconazole ECMO PBPK Model over-predicted exposure (1.13 fold error) but was within the pre-specified acceptance criteria of 0.7-1.3 fold error. PBPK-predicted dosing recommendations showed good agreement with recommendations based on the Fluconazole ECMO PK Trial. The micafungin ECMO PBPK Model also over-predicted exposure (1.16 fold error), but, again, dosing recommendations were in close agreement with recommendations determined from the trial. The two clinical PK trials of fluconazole and micafungin in children on ECMO were performed in parallel with the PBPK model building. Both the Fluconazole and Micafungin ECMO PK Trials showed that exposure was significantly lower in children on ECMO compared to children not on ECMO. Although determining optimal dosing for these two commonly used drugs in children on ECMO was important, more importantly, the PBPK modeling developed in this dissertation demonstrated the utility of this approach to understand and quantify the physiologic alterations driving drug disposition in critically ill children. A more precise, refined, integrated approach for drug dosing in this pediatric sub-population will improve both the safety and efficacy of drug therapy in children supported with ECMO. Advisors/Committee Members: Watt, Kevin, Brouwer, Kim L. R., Thakker, Dhiren, Benjamin, Daniel, Cohen-Wolkowiez, Michael, Dumond, Julie.

Subjects/Keywords: Eshelman School of Pharmacy; Division of Pharmacotherapy and Experimental Therapeutics

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Watt, K. (2016). Physiologically-based Pharmacokinetics in Critically Ill Children. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:354a5455-70d4-43ca-a13a-d1bd3706ba75

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Watt, Kevin. “Physiologically-based Pharmacokinetics in Critically Ill Children.” 2016. Thesis, University of North Carolina. Accessed November 29, 2020. https://cdr.lib.unc.edu/record/uuid:354a5455-70d4-43ca-a13a-d1bd3706ba75.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Watt, Kevin. “Physiologically-based Pharmacokinetics in Critically Ill Children.” 2016. Web. 29 Nov 2020.

Vancouver:

Watt K. Physiologically-based Pharmacokinetics in Critically Ill Children. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2020 Nov 29]. Available from: https://cdr.lib.unc.edu/record/uuid:354a5455-70d4-43ca-a13a-d1bd3706ba75.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Watt K. Physiologically-based Pharmacokinetics in Critically Ill Children. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:354a5455-70d4-43ca-a13a-d1bd3706ba75

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.