Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"University of North Carolina" +contributor:("Dant, Trisha"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of North Carolina

1. Dant, Trisha. Examining Factors Critical to T Cell Suppression and Migration During Acute Graft-Versus-Host Disease.

Degree: Microbiology and Immunology, 2017, University of North Carolina

Allogeneic stem cell transplant (allo-SCT) is a curative therapy for malignant and non-malignant diseases. Unfortunately, acute Graft-versus-Host Disease (aGvHD) is a complication of allo-SCT, and is characterized by migration of donor T cells present in the stem cell graft first to secondary lymphoid tissue (SLT) and then to recipient target organs where they cause inflammation and tissue damage. The purpose of the work described herein is to obtain novel insights into aGvHD pathogenesis. Specifically, we examine ways to modulate T cell function in order to reduce aGvHD. We address new ways to suppress donor T cells first by eliminating the Aryl-hydrocarbon Receptor transcription factor, which caused donor T cells to differentiate into Tregs versus Th17 cells in the colon that consequently reduced aGvHD severity. Secondly, we address suppressing donor T cells through providing ex vivo generated ILC2 cells that are eliminated from recipients during the conditioning regimen, which enhanced the accumulation of MDSCs in the GI tract that both prevented and treated aGvHD. Finally, we examined the impact that modulating actin cytoskeletal dynamics has on T cell function during aGvHD by eliminating the actin-binding protein Coronin 1B. Lack of Coronin 1B resulted in attenuated aGvHD and reduced accumulation in SLT and target organs caused by both a reduction in highly proliferative T cells along with increased cell death. Taken together, our research described extends our knowledge of factors important to T cell function during aGvHD. Advisors/Committee Members: Dant, Trisha, Serody, Jonathan, Wan, Yisong, Hansen, Jonathan, Liu, Zhi, Whitmire, Jason.

Subjects/Keywords: School of Medicine; Department of Microbiology and Immunology

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Dant, T. (2017). Examining Factors Critical to T Cell Suppression and Migration During Acute Graft-Versus-Host Disease. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:60e87d06-bfe3-43b7-9d31-40ca2895bdb9

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Dant, Trisha. “Examining Factors Critical to T Cell Suppression and Migration During Acute Graft-Versus-Host Disease.” 2017. Thesis, University of North Carolina. Accessed November 27, 2020. https://cdr.lib.unc.edu/record/uuid:60e87d06-bfe3-43b7-9d31-40ca2895bdb9.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Dant, Trisha. “Examining Factors Critical to T Cell Suppression and Migration During Acute Graft-Versus-Host Disease.” 2017. Web. 27 Nov 2020.

Vancouver:

Dant T. Examining Factors Critical to T Cell Suppression and Migration During Acute Graft-Versus-Host Disease. [Internet] [Thesis]. University of North Carolina; 2017. [cited 2020 Nov 27]. Available from: https://cdr.lib.unc.edu/record/uuid:60e87d06-bfe3-43b7-9d31-40ca2895bdb9.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dant T. Examining Factors Critical to T Cell Suppression and Migration During Acute Graft-Versus-Host Disease. [Thesis]. University of North Carolina; 2017. Available from: https://cdr.lib.unc.edu/record/uuid:60e87d06-bfe3-43b7-9d31-40ca2895bdb9

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.