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You searched for +publisher:"University of North Carolina" +contributor:("Constance, Brian"). One record found.

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University of North Carolina

1. Constance, Brian. The role of tau in Alzheimer’s Disease: Effects of Lys-280 and Lys-281 acetylation on tau function and structure.

Degree: Pharmacology, 2016, University of North Carolina

The tau protein is implicated in Alzheimer’s disease (AD), and it is a prominent feature of AD pathology. In AD, tau's normal ability to stabilize microtubules (MTs) is impaired, and tau becomes aggregated. Aberrant post-translational modifications (PTMs) of tau may provide an explanation for why this occurs. There are mounting indications that tau acetylation plays a role in AD, with acetylated K280 being discovered as a marker of tau aggregation in AD brain. We hypothesize that acetylation of lysines in tau’s microtubule binding region (MTBR) causes a loss of tau stabilizing function and a gain of propensity to form aggregates. Using lysine to glutamine (K->Q) mutations to model acetylation, we provide evidence suggesting that single (K280) or double (K280/K281) acetylation inhibits MT assembly. Furthermore, we implicate the K280 acetylation in accelerating tau aggregation, and in the seeding of aberrantly phosphorylated, tau aggregation. Advisors/Committee Members: Constance, Brian, Cohen, Todd, Graves, Lee, Nicholas, Robert.

Subjects/Keywords: School of Medicine; Department of Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Constance, B. (2016). The role of tau in Alzheimer’s Disease: Effects of Lys-280 and Lys-281 acetylation on tau function and structure. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:80bdebaf-4ea9-45e7-8bd1-4e1e43c5c11a

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Constance, Brian. “The role of tau in Alzheimer’s Disease: Effects of Lys-280 and Lys-281 acetylation on tau function and structure.” 2016. Thesis, University of North Carolina. Accessed October 28, 2020. https://cdr.lib.unc.edu/record/uuid:80bdebaf-4ea9-45e7-8bd1-4e1e43c5c11a.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Constance, Brian. “The role of tau in Alzheimer’s Disease: Effects of Lys-280 and Lys-281 acetylation on tau function and structure.” 2016. Web. 28 Oct 2020.

Vancouver:

Constance B. The role of tau in Alzheimer’s Disease: Effects of Lys-280 and Lys-281 acetylation on tau function and structure. [Internet] [Thesis]. University of North Carolina; 2016. [cited 2020 Oct 28]. Available from: https://cdr.lib.unc.edu/record/uuid:80bdebaf-4ea9-45e7-8bd1-4e1e43c5c11a.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Constance B. The role of tau in Alzheimer’s Disease: Effects of Lys-280 and Lys-281 acetylation on tau function and structure. [Thesis]. University of North Carolina; 2016. Available from: https://cdr.lib.unc.edu/record/uuid:80bdebaf-4ea9-45e7-8bd1-4e1e43c5c11a

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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