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You searched for +publisher:"University of North Carolina" +contributor:("Clarkson, Michael"). One record found.

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University of North Carolina

1. Clarkson, Michael. Dynamic Effects of Mutations in Eglin c.

Degree: Biochemistry and Biophysics, 2006, University of North Carolina

URL: https://cdr.lib.unc.edu/record/uuid:5a070fe7-5aff-4908-9e6c-782a95fe1a25 

In order to investigate the mechanism of dynamic propagation in proteins and the role these responses play in energetic communication, a series of novel dynamic perturbationresponse experiments using NMR spin-relaxation of 15N and 2H were performed on the serine protease inhibitor eglin c. Although analysis was complicated in some cases by significant structural changes, a considerable number of mutations provoked a substantial response among contiguous side chains while leaving backbone dynamics unaltered. In contrast, some mutations induced dynamic effects that were distributed discontinuously through the protein and associated with very subtle structural changes. Side chains did not always produce reciprocal dynamic responses. Both the "contiguous network responses" and "disperse network responses" were associated with significant free energies of interaction. These results suggest that dynamic networks may play a role in energetic communication. Advisors/Committee Members: Clarkson, Michael, Lee, Andrew, Pielak, Gary J..

Subjects/Keywords: School of Medicine; Department of Biochemistry and Biophysics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Clarkson, M. (2006). Dynamic Effects of Mutations in Eglin c. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:5a070fe7-5aff-4908-9e6c-782a95fe1a25

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Clarkson, Michael. “Dynamic Effects of Mutations in Eglin c.” 2006. Thesis, University of North Carolina. Accessed January 17, 2021. https://cdr.lib.unc.edu/record/uuid:5a070fe7-5aff-4908-9e6c-782a95fe1a25.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Clarkson, Michael. “Dynamic Effects of Mutations in Eglin c.” 2006. Web. 17 Jan 2021.

Vancouver:

Clarkson M. Dynamic Effects of Mutations in Eglin c. [Internet] [Thesis]. University of North Carolina; 2006. [cited 2021 Jan 17]. Available from: https://cdr.lib.unc.edu/record/uuid:5a070fe7-5aff-4908-9e6c-782a95fe1a25.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clarkson M. Dynamic Effects of Mutations in Eglin c. [Thesis]. University of North Carolina; 2006. Available from: https://cdr.lib.unc.edu/record/uuid:5a070fe7-5aff-4908-9e6c-782a95fe1a25

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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