Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"University of New South Wales" +contributor:("Poynten, Ann, Department of Endocrinology, Prince of Wales Hospital, Sydney"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of New South Wales

1. Tummanapalli, Shyam Sunder. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.

Degree: Optometry & Vision Science, 2020, University of New South Wales

Background: Corneal nerve fibers express diffusible, trophic neuropeptides such as substance P and calcitonin gene-related peptide (CGRP) into tears in response to neurogenic inflammation. Impaired corneal nerve fibers have been proposed as early indicators of diabetic peripheral neuropathy (DPN). However, the changes that occur in the concentration of these neuropeptides and their relationship with peripheral neuropathy in the diabetic cohort has not been explored.Aim: To demonstrate the changes the concentrations of substance P and CGRP in tears as a result of corneal denervation in diabetes and their association with severity of DPN. Methods: The concentrations of substance P and CGRP in flush tears were measured by enzyme-linked immunosorbent assay. Corneal nerve fibers were assessed using corneal confocal microscopy. Motor nerve axonal excitability tests were conducted to assess axonal function.Results: Age was identified as a confounding factor and controlled in all subsequent studies. Corneal nerve fiber loss was associated with early markers of axonal dysfunction and severity of neuropathy in type 1 diabetes, suggesting that corneal nerve loss is a generalized neuropathic process. There was a significant reduction in the concentration of substance P in tears in people with type 1 diabetic neuropathy. The concentration of substance P in tears was associated with corneal nerve loss and with the severity of peripheral neuropathy in type 1 diabetes. In type 2 diabetes, there was no difference in neuropeptides between groups, regardless of neuropathic status. In both type 1 and type 2 diabetes, corneal nerve parameters were significantly decreased in DPN. Corneal confocal microscopy had a better diagnostic performance than the nerve excitability measures for detecting DPN in a cohort of participants with type 1 and type 2 diabetes. Tear film substance P concentration had a relatively good diagnostic efficiency in the assessment of DPN and may be used as a potential proxy marker for peripheral neuropathy in type 1 diabetes, but not in type 2 diabetes. The co-existence of renal dysfunction with diabetes does have an added detrimental effect on corneal small nerve fibers.Conclusion: The ocular surface can indeed be a useful means to detect peripheral neuropathic status in diabetes. The measurement of tear film substance P offers significant promise in the detection of DPN. Advisors/Committee Members: Markoulli, Maria, Optometry & Vision Science, Faculty of Science, UNSW, Willcox, Mark, Optometry & Vision Science, Faculty of Science, UNSW, Poynten, Ann, Department of Endocrinology, Prince of Wales Hospital, Sydney.

Subjects/Keywords: Tear neuropeptide; Diabetic peripheral neuropathy; Corneal confocal microscopy; Total neuropathy score; Type 2 diabetes; Tear film; Corneal nerves; Nerve excitability studies; Substance P; Calcitonin gene-related peptide; Chronic kidney disease; Flush tears; Inferior whorl; Fractal dimension; Type 1 diabetes

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Tummanapalli, S. S. (2020). Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

Chicago Manual of Style (16th Edition):

Tummanapalli, Shyam Sunder. “Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.” 2020. Doctoral Dissertation, University of New South Wales. Accessed February 26, 2021. http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true.

MLA Handbook (7th Edition):

Tummanapalli, Shyam Sunder. “Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.” 2020. Web. 26 Feb 2021.

Vancouver:

Tummanapalli SS. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. [Internet] [Doctoral dissertation]. University of New South Wales; 2020. [cited 2021 Feb 26]. Available from: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true.

Council of Science Editors:

Tummanapalli SS. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. [Doctoral Dissertation]. University of New South Wales; 2020. Available from: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

.