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You searched for +publisher:"University of New South Wales" +contributor:("Markoulli, Maria, Optometry & Vision Science, Faculty of Science, UNSW"). Showing records 1 – 2 of 2 total matches.

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University of New South Wales

1. Tummanapalli, Shyam Sunder. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.

Degree: Optometry & Vision Science, 2020, University of New South Wales

Background: Corneal nerve fibers express diffusible, trophic neuropeptides such as substance P and calcitonin gene-related peptide (CGRP) into tears in response to neurogenic inflammation. Impaired corneal nerve fibers have been proposed as early indicators of diabetic peripheral neuropathy (DPN). However, the changes that occur in the concentration of these neuropeptides and their relationship with peripheral neuropathy in the diabetic cohort has not been explored.Aim: To demonstrate the changes the concentrations of substance P and CGRP in tears as a result of corneal denervation in diabetes and their association with severity of DPN. Methods: The concentrations of substance P and CGRP in flush tears were measured by enzyme-linked immunosorbent assay. Corneal nerve fibers were assessed using corneal confocal microscopy. Motor nerve axonal excitability tests were conducted to assess axonal function.Results: Age was identified as a confounding factor and controlled in all subsequent studies. Corneal nerve fiber loss was associated with early markers of axonal dysfunction and severity of neuropathy in type 1 diabetes, suggesting that corneal nerve loss is a generalized neuropathic process. There was a significant reduction in the concentration of substance P in tears in people with type 1 diabetic neuropathy. The concentration of substance P in tears was associated with corneal nerve loss and with the severity of peripheral neuropathy in type 1 diabetes. In type 2 diabetes, there was no difference in neuropeptides between groups, regardless of neuropathic status. In both type 1 and type 2 diabetes, corneal nerve parameters were significantly decreased in DPN. Corneal confocal microscopy had a better diagnostic performance than the nerve excitability measures for detecting DPN in a cohort of participants with type 1 and type 2 diabetes. Tear film substance P concentration had a relatively good diagnostic efficiency in the assessment of DPN and may be used as a potential proxy marker for peripheral neuropathy in type 1 diabetes, but not in type 2 diabetes. The co-existence of renal dysfunction with diabetes does have an added detrimental effect on corneal small nerve fibers.Conclusion: The ocular surface can indeed be a useful means to detect peripheral neuropathic status in diabetes. The measurement of tear film substance P offers significant promise in the detection of DPN. Advisors/Committee Members: Markoulli, Maria, Optometry & Vision Science, Faculty of Science, UNSW, Willcox, Mark, Optometry & Vision Science, Faculty of Science, UNSW, Poynten, Ann, Department of Endocrinology, Prince of Wales Hospital, Sydney.

Subjects/Keywords: Tear neuropeptide; Diabetic peripheral neuropathy; Corneal confocal microscopy; Total neuropathy score; Type 2 diabetes; Tear film; Corneal nerves; Nerve excitability studies; Substance P; Calcitonin gene-related peptide; Chronic kidney disease; Flush tears; Inferior whorl; Fractal dimension; Type 1 diabetes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Tummanapalli, S. S. (2020). Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

Chicago Manual of Style (16th Edition):

Tummanapalli, Shyam Sunder. “Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.” 2020. Doctoral Dissertation, University of New South Wales. Accessed March 09, 2021. http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true.

MLA Handbook (7th Edition):

Tummanapalli, Shyam Sunder. “Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.” 2020. Web. 09 Mar 2021.

Vancouver:

Tummanapalli SS. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. [Internet] [Doctoral dissertation]. University of New South Wales; 2020. [cited 2021 Mar 09]. Available from: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true.

Council of Science Editors:

Tummanapalli SS. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. [Doctoral Dissertation]. University of New South Wales; 2020. Available from: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true


University of New South Wales

2. Alghamdi, Waleed. Impact of contact lens wear on the meibomian glands, lid margin and tear film.

Degree: Optometry & Vision Science, 2016, University of New South Wales

Ocular discomfort and dry eye symptoms are the main reasons for contact lens (CL) wear intolerance and discontinuation. In this context, dry eye and discomfort can be multifactorial, but with a growing clinical impression that physiological changes in the eyelid and meibomian glands (MGs) are involved. Yet, evidence is still inconclusive on the impact of CL wear on MGs and lid margin disease. Thus, this thesis aimed to observe the characteristics of the MGs, eyelids and tear film following varying durations of CL wear or previous CL wear. This thesis consists of three main studies that are clinical, histological and biochemical in nature.In order to achieve this aim, a cross-sectional study was conducted involving a single observation of each member of a sample divided into five groups based on soft contact lens wearing experience. Three groups were existing CL wearers with different exposure durations (short, medium and long); one group had previously worn CLs and had now ceased; and a control group who had never worn CLs. In the clinical study, a series of tests was applied to assess changes in the morphology and function of MGs, lid margin abnormalities, symptoms and related dry eye and ocular surface damage. Alterations to MG morphology and function, poorer tear film stability and lid margin characteristics were found to be associated with CL wear. Although these changes onset during the first two years of wear, prolonged CL exposure beyond this point does not appear to be associated with further modification. Cessation of wear for at least 6 months does not lead to resolution.Following on from these observations a histological study was conducted to investigate the nature of cellular changes in the lid margin epithelium using the impression cytology technique. Histochemical analysis showed that CL wear altered lid margin epithelial cell morphology, cytoplasmic: nuclear ratio and goblet cell density but evidence for increased keratinisation was inconclusive. Next, biochemical studies examined two areas, first changes in the levels of inflammatory mediator MMP-9 in tears and second, the composition of meibum in the context of CL wear. The level of MMP-9 was relatively higher in early years of CL wear whereas meibum composition analysis did not reveal any specific changes with CL wear. Advisors/Committee Members: Papas, Eric, Optometry & Vision Science, Faculty of Science, UNSW, Markoulli, Maria, Optometry & Vision Science, Faculty of Science, UNSW, Holden, Brien, Optometry & Vision Science, Faculty of Science, UNSW.

Subjects/Keywords: Contact lens; Meibomian glands; Dry eye; Lid margin; Tear film

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Alghamdi, W. (2016). Impact of contact lens wear on the meibomian glands, lid margin and tear film. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/56872 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41811/SOURCE02?view=true

Chicago Manual of Style (16th Edition):

Alghamdi, Waleed. “Impact of contact lens wear on the meibomian glands, lid margin and tear film.” 2016. Doctoral Dissertation, University of New South Wales. Accessed March 09, 2021. http://handle.unsw.edu.au/1959.4/56872 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41811/SOURCE02?view=true.

MLA Handbook (7th Edition):

Alghamdi, Waleed. “Impact of contact lens wear on the meibomian glands, lid margin and tear film.” 2016. Web. 09 Mar 2021.

Vancouver:

Alghamdi W. Impact of contact lens wear on the meibomian glands, lid margin and tear film. [Internet] [Doctoral dissertation]. University of New South Wales; 2016. [cited 2021 Mar 09]. Available from: http://handle.unsw.edu.au/1959.4/56872 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41811/SOURCE02?view=true.

Council of Science Editors:

Alghamdi W. Impact of contact lens wear on the meibomian glands, lid margin and tear film. [Doctoral Dissertation]. University of New South Wales; 2016. Available from: http://handle.unsw.edu.au/1959.4/56872 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41811/SOURCE02?view=true

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