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You searched for +publisher:"University of New South Wales" +contributor:("Halliday, Jane , Royal Children\'s Hospital, Melbourne"). One record found.

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University of New South Wales

1. Sinnerbrink , Ingrid Brigitte. The health and developmental outcomes of children with a de novo apparently balanced chromosome rearrangement identified at prenatal diagnosis and the associated psychosocial impact on parents.

Degree: Women's & Children's Health, 2011, University of New South Wales

The prenatal diagnosis of a de novo apparently balanced chromosomal rearrangement (ABCR), poses a geneticcounselling challenge because (a) there is a paucity of long-term health and developmental outcome data on childrenborn with a de novo ABCR; (b) little is known about the psychosocial effects of receiving a prenatal diagnosis of a denovo ABCR on the parent and parent-child relationship; and (c) it is not known if, when and how parental disclosure ofthis genetic information occurs to the child concerned. The aim of this study was to examine these 3 issues byretrospectively ascertaining all liveborn de novo ABCRs detected by prenatal diagnosis in New South Wales and Victoriaover a 10-year period; to administer a structured questionnaire using standardised measures of child health,development and behaviour; parenting and family dynamics; and open-ended questions to explore parental plans fordisclosure. Fifty-eight cases were eligible for inclusion, and 16 cases participated (eligible sample response rate 28%).One child (6%) was born with a congenital anomaly (congenital hip dysplasia) and only 2 children (12.5%) reported achronic health problem (hearing loss and chronic allergies). Children in the present study reported statisticallysignificantly better health than a normal Australian population of children in a number of areas. Our cohort reportedsimilar behavioural concerns, parental perceptions of child development, educational achievement and ability comparedto a normal population of children. The level of parenting stress and quality of family functioning experienced by themajority of parents was reported to be within the normal range. However, 4 (25%) parents reported experiencing difficultyin adjusting to parenting. Two parents (12%) were unsure about disclosure, while 60% of parents, who would disclose,did not mention they would advise their child seek genetic counselling prior to family planning. These results suggestthat children with a prenatally detected de novo ABCR have few long-term health, development or behavioural concerns,but the study is limited by the small sample size. Children are at risk of non-disclosure of their carrier status, and familiesmight benefit from follow-up counselling to facilitate communication of the genetic information to their child. Advisors/Committee Members: Kirk, Edwin, Women's & Children's Health, Faculty of Medicine, UNSW, Meiser, Bettina , Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW, Halliday, Jane , Royal Children's Hospital, Melbourne.

Subjects/Keywords: Outcomes; Chromosome abnormalities; Prenatal diagnosis

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APA (6th Edition):

Sinnerbrink , I. B. (2011). The health and developmental outcomes of children with a de novo apparently balanced chromosome rearrangement identified at prenatal diagnosis and the associated psychosocial impact on parents. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/50890 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9784/SOURCE02?view=true

Chicago Manual of Style (16th Edition):

Sinnerbrink , Ingrid Brigitte. “The health and developmental outcomes of children with a de novo apparently balanced chromosome rearrangement identified at prenatal diagnosis and the associated psychosocial impact on parents.” 2011. Masters Thesis, University of New South Wales. Accessed November 15, 2019. http://handle.unsw.edu.au/1959.4/50890 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9784/SOURCE02?view=true.

MLA Handbook (7th Edition):

Sinnerbrink , Ingrid Brigitte. “The health and developmental outcomes of children with a de novo apparently balanced chromosome rearrangement identified at prenatal diagnosis and the associated psychosocial impact on parents.” 2011. Web. 15 Nov 2019.

Vancouver:

Sinnerbrink IB. The health and developmental outcomes of children with a de novo apparently balanced chromosome rearrangement identified at prenatal diagnosis and the associated psychosocial impact on parents. [Internet] [Masters thesis]. University of New South Wales; 2011. [cited 2019 Nov 15]. Available from: http://handle.unsw.edu.au/1959.4/50890 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9784/SOURCE02?view=true.

Council of Science Editors:

Sinnerbrink IB. The health and developmental outcomes of children with a de novo apparently balanced chromosome rearrangement identified at prenatal diagnosis and the associated psychosocial impact on parents. [Masters Thesis]. University of New South Wales; 2011. Available from: http://handle.unsw.edu.au/1959.4/50890 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9784/SOURCE02?view=true

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