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You searched for +publisher:"University of Michigan" +contributor:("Woodard, Ronald W"). Showing records 1 – 25 of 25 total matches.

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University of Michigan

1. Hansen, Douglas A. Type I Polyketide Synthases: Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity.

Degree: PhD, Medicinal Chemistry, 2015, University of Michigan

 The gram-positive prokaryotes of the Streptomyces genus are prolific producers of secondary metabolites including a plethora of complex polyketide compounds. These natural products are constructed… (more)

Subjects/Keywords: polyketide synthases; Chemistry; Science

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APA (6th Edition):

Hansen, D. A. (2015). Type I Polyketide Synthases: Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/111627

Chicago Manual of Style (16th Edition):

Hansen, Douglas A. “Type I Polyketide Synthases: Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity.” 2015. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/111627.

MLA Handbook (7th Edition):

Hansen, Douglas A. “Type I Polyketide Synthases: Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity.” 2015. Web. 22 Aug 2019.

Vancouver:

Hansen DA. Type I Polyketide Synthases: Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/111627.

Council of Science Editors:

Hansen DA. Type I Polyketide Synthases: Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/111627


University of Michigan

2. Young, Zapporah. Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy.

Degree: PhD, Medicinal Chemistry, 2016, University of Michigan

 Misregulation of tau, an intrinsically disordered protein, is implicated in Alzheimer’s disease (AD) and more than 15 related tauopathies. These diseases are characterized by the… (more)

Subjects/Keywords: Hsp70; Biological Chemistry; Chemistry; Molecular, Cellular and Developmental Biology; Science (General); Science

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APA (6th Edition):

Young, Z. (2016). Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/135795

Chicago Manual of Style (16th Edition):

Young, Zapporah. “Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy.” 2016. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/135795.

MLA Handbook (7th Edition):

Young, Zapporah. “Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy.” 2016. Web. 22 Aug 2019.

Vancouver:

Young Z. Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy. [Internet] [Doctoral dissertation]. University of Michigan; 2016. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/135795.

Council of Science Editors:

Young Z. Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy. [Doctoral Dissertation]. University of Michigan; 2016. Available from: http://hdl.handle.net/2027.42/135795


University of Michigan

3. Jenkins, Ronald J. Phage Display as a Tool for Probing Lipid A Biosynthesis.

Degree: PhD, Medicinal Chemistry, 2013, University of Michigan

 The lipid A biosynthetic pathway is exclusive to gram-negative bacteria, thus making it an ideal target for antimicrobial drug discovery. Furthermore, two distinct acyltransferases, UDP-GlcNAc… (more)

Subjects/Keywords: Lipid A; Phage Display; LpxA; LpxD; Escherichia Coli; Biological Chemistry; Science

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APA (6th Edition):

Jenkins, R. J. (2013). Phage Display as a Tool for Probing Lipid A Biosynthesis. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/98051

Chicago Manual of Style (16th Edition):

Jenkins, Ronald J. “Phage Display as a Tool for Probing Lipid A Biosynthesis.” 2013. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/98051.

MLA Handbook (7th Edition):

Jenkins, Ronald J. “Phage Display as a Tool for Probing Lipid A Biosynthesis.” 2013. Web. 22 Aug 2019.

Vancouver:

Jenkins RJ. Phage Display as a Tool for Probing Lipid A Biosynthesis. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/98051.

Council of Science Editors:

Jenkins RJ. Phage Display as a Tool for Probing Lipid A Biosynthesis. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/98051


University of Michigan

4. Yestrepsky, Bryan Daniel. Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics.

Degree: PhD, Medicinal Chemistry, 2013, University of Michigan

 Resistance to traditional antibiotics arises largely because killing bacteria or halting their reproduction induces a selective pressure on mutants able to survive treatment. Virulence-attenuating antibiotics… (more)

Subjects/Keywords: Antibiotics; Group a Streptococcus; Structure Activity Relationship; Macromolecular Target Identification; Biofilm Inhibition; Chemistry; Science

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APA (6th Edition):

Yestrepsky, B. D. (2013). Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/102329

Chicago Manual of Style (16th Edition):

Yestrepsky, Bryan Daniel. “Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics.” 2013. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/102329.

MLA Handbook (7th Edition):

Yestrepsky, Bryan Daniel. “Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics.” 2013. Web. 22 Aug 2019.

Vancouver:

Yestrepsky BD. Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/102329.

Council of Science Editors:

Yestrepsky BD. Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/102329


University of Michigan

5. Scharf, Nathan. Identification and Evaluation of Bacterial RNA Polymerase Inhibitors Using a Novel Plasmid-based Transcription Assay.

Degree: PhD, Medicinal Chemistry, 2017, University of Michigan

 Tuberculosis (TB) is a global health problem caused by Mycobacterium tuberculosis with 8-10 million new cases each year according to the World Health Organization. The… (more)

Subjects/Keywords: RNA polymerase; transcription; drug discovery; rifampin; high-throughput screen; tuberculosis; Biological Chemistry; Science

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APA (6th Edition):

Scharf, N. (2017). Identification and Evaluation of Bacterial RNA Polymerase Inhibitors Using a Novel Plasmid-based Transcription Assay. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/140941

Chicago Manual of Style (16th Edition):

Scharf, Nathan. “Identification and Evaluation of Bacterial RNA Polymerase Inhibitors Using a Novel Plasmid-based Transcription Assay.” 2017. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/140941.

MLA Handbook (7th Edition):

Scharf, Nathan. “Identification and Evaluation of Bacterial RNA Polymerase Inhibitors Using a Novel Plasmid-based Transcription Assay.” 2017. Web. 22 Aug 2019.

Vancouver:

Scharf N. Identification and Evaluation of Bacterial RNA Polymerase Inhibitors Using a Novel Plasmid-based Transcription Assay. [Internet] [Doctoral dissertation]. University of Michigan; 2017. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/140941.

Council of Science Editors:

Scharf N. Identification and Evaluation of Bacterial RNA Polymerase Inhibitors Using a Novel Plasmid-based Transcription Assay. [Doctoral Dissertation]. University of Michigan; 2017. Available from: http://hdl.handle.net/2027.42/140941

6. Cech, David. Insights into the Mechanistic and Regulatory Properties of D-arabinose-5-phosphate.

Degree: PhD, Medicinal Chemistry, 2017, University of Michigan

 Arabinose-5-phosphate isomerase (API) catalyzes the interconversion of D-ribulose-5-phosphate and D-arabinose-5-phosphate (A5P), which is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate (Kdo). Kdo, an important… (more)

Subjects/Keywords: D-arabinose-5-phosphate isomerase; D-arabinose-5-phosphate; Biological Chemistry; Science

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APA (6th Edition):

Cech, D. (2017). Insights into the Mechanistic and Regulatory Properties of D-arabinose-5-phosphate. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/138618

Chicago Manual of Style (16th Edition):

Cech, David. “Insights into the Mechanistic and Regulatory Properties of D-arabinose-5-phosphate.” 2017. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/138618.

MLA Handbook (7th Edition):

Cech, David. “Insights into the Mechanistic and Regulatory Properties of D-arabinose-5-phosphate.” 2017. Web. 22 Aug 2019.

Vancouver:

Cech D. Insights into the Mechanistic and Regulatory Properties of D-arabinose-5-phosphate. [Internet] [Doctoral dissertation]. University of Michigan; 2017. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/138618.

Council of Science Editors:

Cech D. Insights into the Mechanistic and Regulatory Properties of D-arabinose-5-phosphate. [Doctoral Dissertation]. University of Michigan; 2017. Available from: http://hdl.handle.net/2027.42/138618


University of Michigan

7. Assimon, Victoria A. Strategies for Modulating the Diverse Activities of Heat Shock Protein 70.

Degree: PhD, Chemical Biology, 2015, University of Michigan

 Heat shock protein 70 (Hsp70) is an essential regulator of protein homeostasis. Dysfunction of protein homeostasis is directly linked to many diseases, including cancer and… (more)

Subjects/Keywords: Heat shock protein 70; protein-protein interactions; co-chaperones; allostery; drug-resistant bacteria; protein homeostasis; Biological Chemistry; Science

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APA (6th Edition):

Assimon, V. A. (2015). Strategies for Modulating the Diverse Activities of Heat Shock Protein 70. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/116624

Chicago Manual of Style (16th Edition):

Assimon, Victoria A. “Strategies for Modulating the Diverse Activities of Heat Shock Protein 70.” 2015. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/116624.

MLA Handbook (7th Edition):

Assimon, Victoria A. “Strategies for Modulating the Diverse Activities of Heat Shock Protein 70.” 2015. Web. 22 Aug 2019.

Vancouver:

Assimon VA. Strategies for Modulating the Diverse Activities of Heat Shock Protein 70. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/116624.

Council of Science Editors:

Assimon VA. Strategies for Modulating the Diverse Activities of Heat Shock Protein 70. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/116624


University of Michigan

8. Emanuele, Anthony A. An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri.

Degree: PhD, Medicinal Chemistry, 2016, University of Michigan

 Shigella flexneri is a gram-negative enteropathogen that infects the human colonic epithelium. It is estimated that Shigella spp. infect 165 million people a year worldwide.… (more)

Subjects/Keywords: Antibiotic Discovery Campaign; Shigella; Anti-virulence; VirF; Biological Chemistry; Microbiology and Immunology; Pharmacy and Pharmacology; Chemistry; Science (General); Health Sciences; Science

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APA (6th Edition):

Emanuele, A. A. (2016). An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/120884

Chicago Manual of Style (16th Edition):

Emanuele, Anthony A. “An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri.” 2016. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/120884.

MLA Handbook (7th Edition):

Emanuele, Anthony A. “An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri.” 2016. Web. 22 Aug 2019.

Vancouver:

Emanuele AA. An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri. [Internet] [Doctoral dissertation]. University of Michigan; 2016. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/120884.

Council of Science Editors:

Emanuele AA. An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri. [Doctoral Dissertation]. University of Michigan; 2016. Available from: http://hdl.handle.net/2027.42/120884


University of Michigan

9. Chen, Yi-Chen. Evolution of Eukaryal tRNA-Guanine Transglycosylase: Insight Gained from the Characterization of the Human and Escherichia coli tRNA-Guanine Transglycosylases.

Degree: PhD, Medicinal Chemistry, 2011, University of Michigan

 Of the approximately 100 tRNA modifications that have been identified thus far, queuine (Q, 7-((4, 5-cis-dihydroxy-2-cyclopenten-1-yl) amino) methyl-7-deazaguanine) is one of the most complicated. Although… (more)

Subjects/Keywords: Human TRNA-guanine Transglycosylase; Queuosine Modification; Heterodimeric Subunit Structure; Divergent Evolution of TGT; Characterization of the Eukaryal TGT; Biological Chemistry; Pharmacy and Pharmacology; Health Sciences

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APA (6th Edition):

Chen, Y. (2011). Evolution of Eukaryal tRNA-Guanine Transglycosylase: Insight Gained from the Characterization of the Human and Escherichia coli tRNA-Guanine Transglycosylases. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/84565

Chicago Manual of Style (16th Edition):

Chen, Yi-Chen. “Evolution of Eukaryal tRNA-Guanine Transglycosylase: Insight Gained from the Characterization of the Human and Escherichia coli tRNA-Guanine Transglycosylases.” 2011. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/84565.

MLA Handbook (7th Edition):

Chen, Yi-Chen. “Evolution of Eukaryal tRNA-Guanine Transglycosylase: Insight Gained from the Characterization of the Human and Escherichia coli tRNA-Guanine Transglycosylases.” 2011. Web. 22 Aug 2019.

Vancouver:

Chen Y. Evolution of Eukaryal tRNA-Guanine Transglycosylase: Insight Gained from the Characterization of the Human and Escherichia coli tRNA-Guanine Transglycosylases. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/84565.

Council of Science Editors:

Chen Y. Evolution of Eukaryal tRNA-Guanine Transglycosylase: Insight Gained from the Characterization of the Human and Escherichia coli tRNA-Guanine Transglycosylases. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/84565

10. Pratt, Andrew. Functional Analysis of Early Core Region Modification in the LPS of Gram-negative Bacteria.

Degree: PhD, Medicinal Chemistry, 2017, University of Michigan

 Lipopolysaccharide (LPS) is an essential and medically important glycolipid found in the outer leaflet of the outer membrane of Gram-negative bacteria. LPS plays an important… (more)

Subjects/Keywords: Lipopolysaccharide; Gram-negative; Membrane sciences; Glycolipids; Biological Chemistry; Microbiology and Immunology; Science

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APA (6th Edition):

Pratt, A. (2017). Functional Analysis of Early Core Region Modification in the LPS of Gram-negative Bacteria. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/136946

Chicago Manual of Style (16th Edition):

Pratt, Andrew. “Functional Analysis of Early Core Region Modification in the LPS of Gram-negative Bacteria.” 2017. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/136946.

MLA Handbook (7th Edition):

Pratt, Andrew. “Functional Analysis of Early Core Region Modification in the LPS of Gram-negative Bacteria.” 2017. Web. 22 Aug 2019.

Vancouver:

Pratt A. Functional Analysis of Early Core Region Modification in the LPS of Gram-negative Bacteria. [Internet] [Doctoral dissertation]. University of Michigan; 2017. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/136946.

Council of Science Editors:

Pratt A. Functional Analysis of Early Core Region Modification in the LPS of Gram-negative Bacteria. [Doctoral Dissertation]. University of Michigan; 2017. Available from: http://hdl.handle.net/2027.42/136946

11. Heslip, Kyle Anthony. Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.

Degree: PhD, Medicinal Chemistry, 2015, University of Michigan

 Phosphopantetheine is an essential biomolecule required for life. The enzyme phosphopantothenoylcysteine synthetase (PPCS) incorporates the reactive thiol moiety in the Coenzyme A (CoA) biosynthetic pathway.… (more)

Subjects/Keywords: Coenzyme A; Phosphopantothenoylcysteine synthetase; Saturation Mutagenesis; Lipid A; Acyltransferases; Biological Chemistry; Pharmacy and Pharmacology; Chemistry; Health Sciences; Science

…Target. in Medicinal Chemistry, University of Michigan, College of Pharmacy Yao, J. (2010… …Chemistry, University of Michigan, College of Pharmacy Stanitzek, S., Augustin, M. A., Huber, R… …Biosynthesis. in Medicinal Chemistry, University of Michigan, College of Pharmacy Bartling, C. M… …has previously been screened by our group against 41,000 compounds at the University of… …PPCS has previously been screened by our group against 41,000 compounds at the University of… 

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APA (6th Edition):

Heslip, K. A. (2015). Inhibiting the Actions of Essential Biomolecule Phosphopantetheine. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/111574

Chicago Manual of Style (16th Edition):

Heslip, Kyle Anthony. “Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.” 2015. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/111574.

MLA Handbook (7th Edition):

Heslip, Kyle Anthony. “Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.” 2015. Web. 22 Aug 2019.

Vancouver:

Heslip KA. Inhibiting the Actions of Essential Biomolecule Phosphopantetheine. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/111574.

Council of Science Editors:

Heslip KA. Inhibiting the Actions of Essential Biomolecule Phosphopantetheine. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/111574

12. Yu, Geng. Two Methylketone Biosynthetic Enzymes from Wild Tomatoes.

Degree: PhD, Molecular, Cellular, and Developmental Biology, 2013, University of Michigan

 Many plants make varying amounts of aliphatic 2-methylketones, but their mode of synthesis is unclear. High concentrations of 2-undecanone and 2-tridecanone in the trichomes of… (more)

Subjects/Keywords: Tomato Methylketones; Molecular, Cellular and Developmental Biology; Science

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APA (6th Edition):

Yu, G. (2013). Two Methylketone Biosynthetic Enzymes from Wild Tomatoes. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/102340

Chicago Manual of Style (16th Edition):

Yu, Geng. “Two Methylketone Biosynthetic Enzymes from Wild Tomatoes.” 2013. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/102340.

MLA Handbook (7th Edition):

Yu, Geng. “Two Methylketone Biosynthetic Enzymes from Wild Tomatoes.” 2013. Web. 22 Aug 2019.

Vancouver:

Yu G. Two Methylketone Biosynthetic Enzymes from Wild Tomatoes. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/102340.

Council of Science Editors:

Yu G. Two Methylketone Biosynthetic Enzymes from Wild Tomatoes. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/102340

13. Nwokoye, Adaora. Implementation and Optimization of an in vivo Photo-crosslinking Methodology to Define Direct Targets of Transcriptional Activators.

Degree: PhD, Medicinal Chemistry, 2012, University of Michigan

 Protein-protein interactions are primarily used to accomplish many biological processes. Understanding protein-protein interactions, particularly, the direct interacting proteins and mechanism for interaction, is instrumental to… (more)

Subjects/Keywords: Transcriptional Activator Direct Targets; Direct Targets of Yeast Gal4; Using Photo-crosslinking to Define Direct Targets of Activators; In Vivo Photo-crosslinking Methodology; Defining Protein-protien Interactions Within Transcription; Protein-protein Interactions Carried Out by Activators; Health Sciences

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APA (6th Edition):

Nwokoye, A. (2012). Implementation and Optimization of an in vivo Photo-crosslinking Methodology to Define Direct Targets of Transcriptional Activators. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/91515

Chicago Manual of Style (16th Edition):

Nwokoye, Adaora. “Implementation and Optimization of an in vivo Photo-crosslinking Methodology to Define Direct Targets of Transcriptional Activators.” 2012. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/91515.

MLA Handbook (7th Edition):

Nwokoye, Adaora. “Implementation and Optimization of an in vivo Photo-crosslinking Methodology to Define Direct Targets of Transcriptional Activators.” 2012. Web. 22 Aug 2019.

Vancouver:

Nwokoye A. Implementation and Optimization of an in vivo Photo-crosslinking Methodology to Define Direct Targets of Transcriptional Activators. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/91515.

Council of Science Editors:

Nwokoye A. Implementation and Optimization of an in vivo Photo-crosslinking Methodology to Define Direct Targets of Transcriptional Activators. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/91515

14. Joseph, Caleb G. Substrate Specificity of Metal-Dependent Lysine Deacetylases.

Degree: PhD, Medicinal Chemistry, 2012, University of Michigan

 Lysine deacetylases (KDACs) catalyze the deacetylation of acetylated lysine residues on histones and other protein substrates. This modification plays a vital role in numerous cellular… (more)

Subjects/Keywords: KDAC8 , KDAC11; Biological Chemistry; Science

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APA (6th Edition):

Joseph, C. G. (2012). Substrate Specificity of Metal-Dependent Lysine Deacetylases. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/93860

Chicago Manual of Style (16th Edition):

Joseph, Caleb G. “Substrate Specificity of Metal-Dependent Lysine Deacetylases.” 2012. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/93860.

MLA Handbook (7th Edition):

Joseph, Caleb G. “Substrate Specificity of Metal-Dependent Lysine Deacetylases.” 2012. Web. 22 Aug 2019.

Vancouver:

Joseph CG. Substrate Specificity of Metal-Dependent Lysine Deacetylases. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/93860.

Council of Science Editors:

Joseph CG. Substrate Specificity of Metal-Dependent Lysine Deacetylases. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/93860

15. Zverina, Elaina A. Investigation of Candida albicans Prenyltransferases: Substrate Recognition and Enzyme Inhibition.

Degree: PhD, Chemical Biology, 2012, University of Michigan

 Prenylation is a post-translational modification that is essential for the proper membrane localization of many cellular proteins. Protein prenylation is carried out by protein farnesyltransferase… (more)

Subjects/Keywords: Protein Prenyltransferases; Biological Chemistry; Science

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APA (6th Edition):

Zverina, E. A. (2012). Investigation of Candida albicans Prenyltransferases: Substrate Recognition and Enzyme Inhibition. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/95975

Chicago Manual of Style (16th Edition):

Zverina, Elaina A. “Investigation of Candida albicans Prenyltransferases: Substrate Recognition and Enzyme Inhibition.” 2012. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/95975.

MLA Handbook (7th Edition):

Zverina, Elaina A. “Investigation of Candida albicans Prenyltransferases: Substrate Recognition and Enzyme Inhibition.” 2012. Web. 22 Aug 2019.

Vancouver:

Zverina EA. Investigation of Candida albicans Prenyltransferases: Substrate Recognition and Enzyme Inhibition. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/95975.

Council of Science Editors:

Zverina EA. Investigation of Candida albicans Prenyltransferases: Substrate Recognition and Enzyme Inhibition. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/95975

16. Anand, Jessica P. The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking.

Degree: PhD, Medicinal Chemistry, 2013, University of Michigan

 Opioids are widely used in the treatment of pain; however, the development of tolerance and dependence limit clinical use. The co-administration of a µ opioid… (more)

Subjects/Keywords: Interactions of Mu and Delta Opioid Receptors; Biological Chemistry; Pharmacy and Pharmacology; Science (General); Health Sciences; Science

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APA (6th Edition):

Anand, J. P. (2013). The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/102338

Chicago Manual of Style (16th Edition):

Anand, Jessica P. “The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking.” 2013. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/102338.

MLA Handbook (7th Edition):

Anand, Jessica P. “The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking.” 2013. Web. 22 Aug 2019.

Vancouver:

Anand JP. The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/102338.

Council of Science Editors:

Anand JP. The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/102338

17. Gu, Liangcai. Biosynthetic Innovation on A Polyketide Assembly Line: Biochemical Studies of Curacin A Pathway.

Degree: PhD, Medicinal Chemistry, 2008, University of Michigan

 The chemical diversity of natural products is fueled by the emergence and ongoing evolution of biosynthetic pathways in secondary metabolism. However, enzyme evolution in natural… (more)

Subjects/Keywords: Biosynthesis of Natural Products; GNAT; Cyclopropane; Polyketide Beta-branching; Halogenase; Sulfotransferase; Biological Chemistry; Science

…thank everyone with whom I had the pleasure to work with at University of Michigan: Dr. Kate… 

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APA (6th Edition):

Gu, L. (2008). Biosynthetic Innovation on A Polyketide Assembly Line: Biochemical Studies of Curacin A Pathway. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/61623

Chicago Manual of Style (16th Edition):

Gu, Liangcai. “Biosynthetic Innovation on A Polyketide Assembly Line: Biochemical Studies of Curacin A Pathway.” 2008. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/61623.

MLA Handbook (7th Edition):

Gu, Liangcai. “Biosynthetic Innovation on A Polyketide Assembly Line: Biochemical Studies of Curacin A Pathway.” 2008. Web. 22 Aug 2019.

Vancouver:

Gu L. Biosynthetic Innovation on A Polyketide Assembly Line: Biochemical Studies of Curacin A Pathway. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/61623.

Council of Science Editors:

Gu L. Biosynthetic Innovation on A Polyketide Assembly Line: Biochemical Studies of Curacin A Pathway. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/61623

18. Kawamoto, Steven Akira. Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.

Degree: PhD, Medicinal Chemistry, 2010, University of Michigan

 Wnt signaling plays a critical role in numerous cellular processes including embryonic development, cell proliferation and tissue homeostasis. The multifunctional protein β-catenin is the primary… (more)

Subjects/Keywords: BCL9; BCL9 Inhibitors; Beta-catenin; Wnt Signaling; Cancer; Triazole Stapling; Biological Chemistry; Molecular, Cellular and Developmental Biology; Oncology and Hematology; Chemistry; Science (General); Health Sciences; Science

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APA (6th Edition):

Kawamoto, S. A. (2010). Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/75846

Chicago Manual of Style (16th Edition):

Kawamoto, Steven Akira. “Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.” 2010. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/75846.

MLA Handbook (7th Edition):

Kawamoto, Steven Akira. “Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.” 2010. Web. 22 Aug 2019.

Vancouver:

Kawamoto SA. Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy. [Internet] [Doctoral dissertation]. University of Michigan; 2010. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/75846.

Council of Science Editors:

Kawamoto SA. Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy. [Doctoral Dissertation]. University of Michigan; 2010. Available from: http://hdl.handle.net/2027.42/75846


University of Michigan

19. Burke, Fernanda Ferraccioli Marques. Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation.

Degree: PhD, Medicinal Chemistry, 2007, University of Michigan

 Inhibitors of the activation of platelet aggregation have promise as important therapeutic agents for the management of acute coronary syndrome. Platelet activation by thrombin occurs… (more)

Subjects/Keywords: Novel Peptide Inhibitors of Thrombin and PARs; Medicine (General); Health Sciences

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APA (6th Edition):

Burke, F. F. M. (2007). Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/57691

Chicago Manual of Style (16th Edition):

Burke, Fernanda Ferraccioli Marques. “Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation.” 2007. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/57691.

MLA Handbook (7th Edition):

Burke, Fernanda Ferraccioli Marques. “Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation.” 2007. Web. 22 Aug 2019.

Vancouver:

Burke FFM. Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation. [Internet] [Doctoral dissertation]. University of Michigan; 2007. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/57691.

Council of Science Editors:

Burke FFM. Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation. [Doctoral Dissertation]. University of Michigan; 2007. Available from: http://hdl.handle.net/2027.42/57691


University of Michigan

20. Li, Jingjing. Substrate Specificity and Metal Requirements of 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase (KDOPS).

Degree: PhD, Chemistry, 2008, University of Michigan

 3-Deoxy-D-manno-octulosonate 8-phosphate synthase (KDOPS) catalyzes the aldol-type condensation of D-arabinose 5-phosphate (A5P) and phosphoenolpyruvate (PEP) to form 3-deoxy-D-manno-octulosonate 8-phosphate (KDO8P) and inorganic phosphate. This reaction… (more)

Subjects/Keywords: KDOPS; Substrate Specificity; Metal Requirements; Chemistry; Science

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APA (6th Edition):

Li, J. (2008). Substrate Specificity and Metal Requirements of 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase (KDOPS). (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/58440

Chicago Manual of Style (16th Edition):

Li, Jingjing. “Substrate Specificity and Metal Requirements of 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase (KDOPS).” 2008. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/58440.

MLA Handbook (7th Edition):

Li, Jingjing. “Substrate Specificity and Metal Requirements of 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase (KDOPS).” 2008. Web. 22 Aug 2019.

Vancouver:

Li J. Substrate Specificity and Metal Requirements of 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase (KDOPS). [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/58440.

Council of Science Editors:

Li J. Substrate Specificity and Metal Requirements of 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase (KDOPS). [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/58440


University of Michigan

21. Hagena, Tara Lynn. Selenium-Containing Glycosides and Glycosyl Phosphates as Precursors of Glycosyl Epoxides: New Approaches to the Synthesis of (5-Fluoro) and (5-Cyano) Glycosides.

Degree: PhD, Chemistry, 2008, University of Michigan

 ABSTRACT Enzyme-catalyzed transformations of carbohydrates proceed through different transition states, which may be studied by altering the electron density at various positions of the carbohydrate… (more)

Subjects/Keywords: (5-fluoro) Glycosides; (5-cyano) Glycosides; Chemistry; Science

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APA (6th Edition):

Hagena, T. L. (2008). Selenium-Containing Glycosides and Glycosyl Phosphates as Precursors of Glycosyl Epoxides: New Approaches to the Synthesis of (5-Fluoro) and (5-Cyano) Glycosides. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/58513

Chicago Manual of Style (16th Edition):

Hagena, Tara Lynn. “Selenium-Containing Glycosides and Glycosyl Phosphates as Precursors of Glycosyl Epoxides: New Approaches to the Synthesis of (5-Fluoro) and (5-Cyano) Glycosides.” 2008. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/58513.

MLA Handbook (7th Edition):

Hagena, Tara Lynn. “Selenium-Containing Glycosides and Glycosyl Phosphates as Precursors of Glycosyl Epoxides: New Approaches to the Synthesis of (5-Fluoro) and (5-Cyano) Glycosides.” 2008. Web. 22 Aug 2019.

Vancouver:

Hagena TL. Selenium-Containing Glycosides and Glycosyl Phosphates as Precursors of Glycosyl Epoxides: New Approaches to the Synthesis of (5-Fluoro) and (5-Cyano) Glycosides. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/58513.

Council of Science Editors:

Hagena TL. Selenium-Containing Glycosides and Glycosyl Phosphates as Precursors of Glycosyl Epoxides: New Approaches to the Synthesis of (5-Fluoro) and (5-Cyano) Glycosides. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/58513


University of Michigan

22. Yi, Li. Studies of 3-Deoxy-D-manno-octulosonate 8-Phosphate Phosphatase: Mechanistic Insights and a Gene Fusion Example.

Degree: PhD, Chemistry, 2009, University of Michigan

 3-Deoxy-D-manno-octulosonate (KDO) is a carbohydrate molecule required for integrity of Gram-negative bacterial outer membrane, therefore its biosynthesis is a potential antibiotic target. In addition to… (more)

Subjects/Keywords: KDO Biosynthetic Pathway; Lipopolysaccharide; Haloacid Dehalogenase Superfamily; 3-deoxy-D-manno-Octulosonate 8-phosphate Phosphatase "KDO8P"; Fusion Gene; Biological Chemistry; Science

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APA (6th Edition):

Yi, L. (2009). Studies of 3-Deoxy-D-manno-octulosonate 8-Phosphate Phosphatase: Mechanistic Insights and a Gene Fusion Example. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/62252

Chicago Manual of Style (16th Edition):

Yi, Li. “Studies of 3-Deoxy-D-manno-octulosonate 8-Phosphate Phosphatase: Mechanistic Insights and a Gene Fusion Example.” 2009. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/62252.

MLA Handbook (7th Edition):

Yi, Li. “Studies of 3-Deoxy-D-manno-octulosonate 8-Phosphate Phosphatase: Mechanistic Insights and a Gene Fusion Example.” 2009. Web. 22 Aug 2019.

Vancouver:

Yi L. Studies of 3-Deoxy-D-manno-octulosonate 8-Phosphate Phosphatase: Mechanistic Insights and a Gene Fusion Example. [Internet] [Doctoral dissertation]. University of Michigan; 2009. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/62252.

Council of Science Editors:

Yi L. Studies of 3-Deoxy-D-manno-octulosonate 8-Phosphate Phosphatase: Mechanistic Insights and a Gene Fusion Example. [Doctoral Dissertation]. University of Michigan; 2009. Available from: http://hdl.handle.net/2027.42/62252


University of Michigan

23. Ghirtis, Konstantinos. I. Novel Instructional Technology Tools in Teaching Pharmaceutical Analysis Laboratories. II. New Approaches Towards the Synthesis of Sugar Amino-Acids.

Degree: PhD, Medicinal Chemistry, 2009, University of Michigan

 I. Maintaining high standards of science training is important for pharmacy graduates to practice knowledgeably, responsibly, and confidently. Instrumentation and resource constraints are maximal in… (more)

Subjects/Keywords: Instructional Educational Technology; Pharmaceutical Analysis Laboratory; Aza-sugar; Radical Cyclization; Cancer Metastasis Heparanase; Mitsunobu Reaction; Pharmacy and Pharmacology; Health Sciences

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APA (6th Edition):

Ghirtis, K. (2009). I. Novel Instructional Technology Tools in Teaching Pharmaceutical Analysis Laboratories. II. New Approaches Towards the Synthesis of Sugar Amino-Acids. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/62408

Chicago Manual of Style (16th Edition):

Ghirtis, Konstantinos. “I. Novel Instructional Technology Tools in Teaching Pharmaceutical Analysis Laboratories. II. New Approaches Towards the Synthesis of Sugar Amino-Acids.” 2009. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/62408.

MLA Handbook (7th Edition):

Ghirtis, Konstantinos. “I. Novel Instructional Technology Tools in Teaching Pharmaceutical Analysis Laboratories. II. New Approaches Towards the Synthesis of Sugar Amino-Acids.” 2009. Web. 22 Aug 2019.

Vancouver:

Ghirtis K. I. Novel Instructional Technology Tools in Teaching Pharmaceutical Analysis Laboratories. II. New Approaches Towards the Synthesis of Sugar Amino-Acids. [Internet] [Doctoral dissertation]. University of Michigan; 2009. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/62408.

Council of Science Editors:

Ghirtis K. I. Novel Instructional Technology Tools in Teaching Pharmaceutical Analysis Laboratories. II. New Approaches Towards the Synthesis of Sugar Amino-Acids. [Doctoral Dissertation]. University of Michigan; 2009. Available from: http://hdl.handle.net/2027.42/62408


University of Michigan

24. Lee, Hyang-Yeol. Design of New Bio-Materials: Fluorous Peptides and Metal-Peptides Frameworks.

Degree: PhD, Chemistry, 2008, University of Michigan

 Perfluorocarbons have unique and valuable physical properties not found in Nature. By incorporating fluorine into proteins, it might be possible to produce biological molecules with… (more)

Subjects/Keywords: Fluorinated Protein; Metal-Peptides Frameworks; Chemistry; Science

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APA (6th Edition):

Lee, H. (2008). Design of New Bio-Materials: Fluorous Peptides and Metal-Peptides Frameworks. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/58424

Chicago Manual of Style (16th Edition):

Lee, Hyang-Yeol. “Design of New Bio-Materials: Fluorous Peptides and Metal-Peptides Frameworks.” 2008. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/58424.

MLA Handbook (7th Edition):

Lee, Hyang-Yeol. “Design of New Bio-Materials: Fluorous Peptides and Metal-Peptides Frameworks.” 2008. Web. 22 Aug 2019.

Vancouver:

Lee H. Design of New Bio-Materials: Fluorous Peptides and Metal-Peptides Frameworks. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/58424.

Council of Science Editors:

Lee H. Design of New Bio-Materials: Fluorous Peptides and Metal-Peptides Frameworks. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/58424


University of Michigan

25. Li, Shengying. Biochemical, Structural, and Bioengineering Studies of Cytochrome P450 Enzymes Involved in Biosynthesis of Secondary Metabolites.

Degree: PhD, Medicinal Chemistry, 2009, University of Michigan

 The superfamily of cytochrome P450 monooxygenases is involved in diverse oxidative processes including xenobiotic catabolism, steroid synthesis, and biosynthetic tailoring of diverse natural products. During… (more)

Subjects/Keywords: P450; Biosynthesis; Secondary Metabolites; PikC; Bioengineering; Pikromycin; Biological Chemistry; Science

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APA (6th Edition):

Li, S. (2009). Biochemical, Structural, and Bioengineering Studies of Cytochrome P450 Enzymes Involved in Biosynthesis of Secondary Metabolites. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/64678

Chicago Manual of Style (16th Edition):

Li, Shengying. “Biochemical, Structural, and Bioengineering Studies of Cytochrome P450 Enzymes Involved in Biosynthesis of Secondary Metabolites.” 2009. Doctoral Dissertation, University of Michigan. Accessed August 22, 2019. http://hdl.handle.net/2027.42/64678.

MLA Handbook (7th Edition):

Li, Shengying. “Biochemical, Structural, and Bioengineering Studies of Cytochrome P450 Enzymes Involved in Biosynthesis of Secondary Metabolites.” 2009. Web. 22 Aug 2019.

Vancouver:

Li S. Biochemical, Structural, and Bioengineering Studies of Cytochrome P450 Enzymes Involved in Biosynthesis of Secondary Metabolites. [Internet] [Doctoral dissertation]. University of Michigan; 2009. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/2027.42/64678.

Council of Science Editors:

Li S. Biochemical, Structural, and Bioengineering Studies of Cytochrome P450 Enzymes Involved in Biosynthesis of Secondary Metabolites. [Doctoral Dissertation]. University of Michigan; 2009. Available from: http://hdl.handle.net/2027.42/64678

.