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1.
Huh, Sam Seoung.
Preliminary Study of an Intra-operative PET Imaging Probe System.
Degree: PhD, Biomedical Engineering, 2011, University of Michigan
URL: http://hdl.handle.net/2027.42/86331 
► PET imaging has gained widespread acceptance in cancer imaging because Positron Emission Tomography can identify physiological changes due to cancer. Nevertheless conventional PET imaging has…
(more)
▼ PET imaging has gained widespread acceptance in cancer imaging because Positron Emission Tomography can identify physiological changes due to cancer. Nevertheless conventional PET imaging has difficulty detecting tumors less than 1cm in diameter in clinical use due mainly to background radiation, statistical noise, resolution loss due to lack of depth interaction resolution in detectors, and annihilation photon acolinearity.
Conventionally if detected tumors are surgically removable, surgeons locate and remove the tumors during surgery based on the preoperative scans. One of the drawbacks of relying solely on preoperative imaging is that tumor locations could be displaced during surgery due to patient’s movement.
In this dissertation, a preliminary study of an intra-operative PET imaging probe system is presented. The proposed probe system consists of a low resolution partial ring detector and a high resolution imaging probe that is equipped with a position tracker. The high resolution probe operates in coincidence with the partial ring detector. The high resolution imaging probe and its proximity to target lesions contribute to the localization of small tumors. In addition, the probe system can be used to detect occult tumors. The ultimate goal is to provide incremental 3-dimensional reconstructed images that are re-projected in real time onto a plane whose orientation is driven by the tracking device.
A prototype of the PET imaging probe system was built to test the feasibility of the intra-operative PET imaging probe system. Coincidence detection efficiency of about 0.00012% was observed. A variant of 3-dimensional one-pass list-mode maximum likelihood algorithm (OP-LML) was developed to reconstruct images from the measured data. A row-action maximum likelihood algorithm was integrated with the OP-LML. To speed up image reconstruction by a factor of 30-40, the proposed algorithm was parallelized and was run on a graphics processing unit.
Reconstructed images from simulated data with no intrinsic blurring showed resolution of 1.0mm~1.5mm FWHM. However as we expected, reconstructed images from the experimental set-up with limitations failed to separate two Na-22 point sources 1.5mm apart. Experimental resolutions of 4mm FWHM in the longitudinal direction and 2mm FWHM in the transverse direction were obtained for the two point sources.
Advisors/Committee Members: Clinthorne, Neal H. (committee member), Rogers, W. Leslie (committee member), Fessler, Jeffrey A. (committee member), He, Zhong (committee member).
Subjects/Keywords: Realtime Intraopeative PET Imaging; Online Parallel Image Reconstruction; Modified One Pass MLEM; Surgical PET Imaging Probe System; Image Guided Surgery; Biomedical Engineering; Engineering
…UNIVERSITY OF MICHIGAN. ........................................................... 238
FIGURE 5…
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APA (6th Edition):
Huh, S. S. (2011). Preliminary Study of an Intra-operative PET Imaging Probe System. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/86331
Chicago Manual of Style (16th Edition):
Huh, Sam Seoung. “Preliminary Study of an Intra-operative PET Imaging Probe System.” 2011. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/86331.
MLA Handbook (7th Edition):
Huh, Sam Seoung. “Preliminary Study of an Intra-operative PET Imaging Probe System.” 2011. Web. 15 Jan 2021.
Vancouver:
Huh SS. Preliminary Study of an Intra-operative PET Imaging Probe System. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/86331.
Council of Science Editors:
Huh SS. Preliminary Study of an Intra-operative PET Imaging Probe System. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/86331
University of Michigan
2.
Long, Yong.
Statistical Image Reconstruction and Motion Estimation for Image-Guided Radiotherapy.
Degree: PhD, Electrical Engineering: Systems, 2011, University of Michigan
URL: http://hdl.handle.net/2027.42/86254
► Image reconstruction and motion estimation are very important for image-guided radiotherapy (IGRT). Three-dimensional reconstruction of patient anatomy using X-ray computed tomography (CT) allows identification of…
(more)
▼ Image reconstruction and motion estimation are very important for image-guided radiotherapy
(IGRT). Three-dimensional reconstruction of patient anatomy using X-ray computed tomography
(CT) allows identification of the location of a tumor prior to treatment. The locations of tumorsmay change during actual treatment due to movement such as respiratory motion. Motion estimation helps optimize the accuracy and precision of radiotherapy so that more of the normal surrounding tissue can be spared. This dissertation addresses several important issues related to these two core components of IGRT.
Firstly, we developed two new separable footprint (SF) projector methods for X-ray conebeam
CT. The SF projectors approximate the voxel footprint functions as 2D separable functions.
The SF-TR projector uses trapezoid functions in the transaxial direction and rectangular functions
in the axial direction, whereas the SF-TT projector uses trapezoid functions in both directions. Both SF projector methods are more accurate than the distance-driven (DD) projector, which is a current state-of-the-art method in the field. The SF-TT projector is more accurate than the SF-TR projector for rays associated with large cone angles. In addition, the SF-TR projector has similar computation speed with the DD projector and the SF-TT projector is about two times slower.
Secondly, we proposed a statistical penalized weighted least-squares (PWLS) method with
edge-preserving regularization to reconstruct two basis materials from a single-energy CT scan
acquired with differential filtration, such as a split filter or a bow-tie filter. It requires only the use of suitable filters between the X-ray tube and the patient. For both filtration methods, the proposed PWLS method reconstructed soft tissue and bone images with lower RMS errors, reduced the beam-hardening artifacts much more effectively and produced lower noise, as compared with the traditional non-iterative Joseph and Spital method.
Thirdly, we conducted an objective characterization of the influence of rotational arc length on accuracy of motion estimation for projection-to-volume targeting during rotational therapy. Simulations illustrate the potential accuracy of limited-angle projection-to-volume alignment. Registration accuracy can be sensitive to angular center, tends to be lower along direction of the projection set, and tends to decrease away from the rotation center.
Advisors/Committee Members: Balter, James M. (committee member), Fessler, Jeffrey A. (committee member), Clinthorne, Neal H. (committee member), Hero Iii, Alfred O. (committee member), Meyer, Charles R. (committee member).
Subjects/Keywords: X-Ray CT; Statistical Image Reconstruction; Image-Guided Radiotherapy; Image Registration; Forward and Back-projection; Dual-Energy CT; Electrical Engineering; Engineering
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APA (6th Edition):
Long, Y. (2011). Statistical Image Reconstruction and Motion Estimation for Image-Guided Radiotherapy. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/86254
Chicago Manual of Style (16th Edition):
Long, Yong. “Statistical Image Reconstruction and Motion Estimation for Image-Guided Radiotherapy.” 2011. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/86254.
MLA Handbook (7th Edition):
Long, Yong. “Statistical Image Reconstruction and Motion Estimation for Image-Guided Radiotherapy.” 2011. Web. 15 Jan 2021.
Vancouver:
Long Y. Statistical Image Reconstruction and Motion Estimation for Image-Guided Radiotherapy. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/86254.
Council of Science Editors:
Long Y. Statistical Image Reconstruction and Motion Estimation for Image-Guided Radiotherapy. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/86254
3.
Wang, Yi.
High Detective Quantum Efficiency Electronic Portal Imaging Devices Based on Segmented Crystalline Scintillators and Mercuric Iodide Photoconductors.
Degree: PhD, Biomedical Engineering, 2009, University of Michigan
URL: http://hdl.handle.net/2027.42/63728
► Electronic portal imaging devices (EPIDs) based on active matrix, flat-panel imagers (AMFPIs) have been widely used for patient set-up verification in radiotherapy, and are being…
(more)
▼ Electronic portal imaging devices (EPIDs) based on active matrix, flat-panel imagers (AMFPIs) have been widely used for patient set-up verification in radiotherapy, and are being investigated for megavoltage (MV) cone-beam computed tomography (CBCT). However, the performance of conventional AMFPI-based EPIDs is limited by their relatively low detective quantum efficiency (DQE) at radiotherapy energies, ~1% for 6 MV X rays. Consequently, MV CBCT carried out with these inefficient EPIDs requires impractically high doses to achieve soft-tissue visualization. In order to significantly improve DQE, this research work examined thick mercuric iodide (HgI2) photoconductors in the form of particle in binder (PIB) and thick, segmented scintillators consisting of 2D matrices of scintillating crystals separated by septal walls.
Through simulation of radiation transport, quantum efficiency (QE), modulation transfer function (MTF) and DQE were studied as a function of the thickness of PIB-HgI2 photoconductors. Simulations of radiation and optical transport were carried out to investigate how various geometric and optical properties affect the DQE for segmented CsI:Tl and BGO scintillators. Four prototype EPIDs, employing three CsI:Tl scintillators (11.4, 25.6 and 40.0 mm thick) and one BGO scintillator (11.3 mm thick), were evaluated using a 6 MV photon beam. Finally, the potential MV CBCT performance provided by segmented scintillators was investigated by simulation of radiation transport.
Compared to conventional EPIDs, PIB-HgI2 photoconductors up to 6 mm thick have the potential to provide up to a factor of ~5 improvement in DQE. Segmented CsI:Tl and BGO scintillators up to 40 mm thick can provide DQE improvement of up to a factor of ~29 and 42, respectively, through optimization of optical properties. The three CsI:Tl prototypes demonstrated DQE improvement of up to a factor of ~25 at low spatial frequencies, while the BGO prototype exhibited an improvement of a factor of ~20 at zero frequency and over a factor of ~10 at the Nyquist frequency. The simulation results indicate that CsI:Tl and BGO scintillators up to 40 mm thick can provide dose reduction for MV CBCT of up to a factor of ~51 and 59, respectively, creating the possibility of providing soft-tissue visualization at clinically acceptable doses.
Advisors/Committee Members: Antonuk, Larry E. (committee member), Rogers, W. Leslie (committee member), Clarke, Roy (committee member), Clinthorne, Neal H. (committee member).
Subjects/Keywords: Active Matrix, Flat-panel Imager; Electronic Portal Imaging Devices; Megavoltage Cone-beam CT; Segmented Crystalline Scintillators;
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APA (6th Edition):
Wang, Y. (2009). High Detective Quantum Efficiency Electronic Portal Imaging Devices Based on Segmented Crystalline Scintillators and Mercuric Iodide Photoconductors. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/63728
Chicago Manual of Style (16th Edition):
Wang, Yi. “High Detective Quantum Efficiency Electronic Portal Imaging Devices Based on Segmented Crystalline Scintillators and Mercuric Iodide Photoconductors.” 2009. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/63728.
MLA Handbook (7th Edition):
Wang, Yi. “High Detective Quantum Efficiency Electronic Portal Imaging Devices Based on Segmented Crystalline Scintillators and Mercuric Iodide Photoconductors.” 2009. Web. 15 Jan 2021.
Vancouver:
Wang Y. High Detective Quantum Efficiency Electronic Portal Imaging Devices Based on Segmented Crystalline Scintillators and Mercuric Iodide Photoconductors. [Internet] [Doctoral dissertation]. University of Michigan; 2009. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/63728.
Council of Science Editors:
Wang Y. High Detective Quantum Efficiency Electronic Portal Imaging Devices Based on Segmented Crystalline Scintillators and Mercuric Iodide Photoconductors. [Doctoral Dissertation]. University of Michigan; 2009. Available from: http://hdl.handle.net/2027.42/63728
University of Michigan
4.
Joshi, Aniket.
Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies.
Degree: PhD, Biomedical Engineering, 2008, University of Michigan
URL: http://hdl.handle.net/2027.42/61729
► Positron emission tomography (PET) is a medical imaging modality offering a powerful tool for brain research by mapping of in vivo neuropharmacological functions such as…
(more)
▼ Positron emission tomography (PET) is a medical imaging modality offering a powerful tool for brain research by mapping of in vivo neuropharmacological functions such as metabolism, enzyme activity, and neuroreceptor binding site density and occupancy.
Quantification in brain-PET can be classified into: 1) accurate quantification of radiotracer distribution such that image values are proportional to the radiotracer concentration in tissue, and 2) accurate quantification of the pharmacological state of the system-of-interest. This thesis addresses both these aspects for functional neuroreceptor imaging studies of the living brain.
Traditional brain PET studies have at least two primary limitations. First, they measure only a single neuropharmacological aspect in isolation, which is often insufficient for characterizing a neurological condition. Second, data acquisition is accompanied by the invasive arterial blood sampling for measuring the input function to the system-of-interest. The motivation for this thesis was to address both these limitations, which led to the development of quantitative methods for multiple neuropharmacological PET studies performed without blood sampling. One such experimental design investigated was a dual-measurement intervention study where the system-of-interest is perturbed with the intent of changing the subject’s pharmacological status and system parameters are estimated both pre- and post-intervention. Second was a dual-tracer study where two radiotracers targeting two different neuropharmacological systems were injected closely in time in the same study.
A major challenge in analyzing multiple pharmacological PET studies is the statistical noise-induced bias and variance in the parameter estimates. Methods developed in this thesis reduced almost all the bias (>90%) in the intervention studies with a corresponding improvement in precision. Parameter estimates for dual-tracer studies were obtained with inter-subject regions-of-interest means within ±10% of those obtained from single-tracer scans without appreciable increase in variance.
The thesis also addresses inter-scanner PET image variability, a major confound in multi-center studies used to investigate disease progression. Since various PET centers have scanners with different hardware and software, systematic differences exist in multi-center data. This thesis develops a framework to reduce the inter-scanner PET image variability before pooling multi-center data for analysis. The methods developed reduced variability in phantom scans from different sites by approximately 50%.
Advisors/Committee Members: Fessler, Jeffrey A. (committee member), Koeppe, Robert A. (committee member), Clinthorne, Neal H. (committee member), Meyer, Charles R. (committee member), Noll, Douglas C. (committee member).
Subjects/Keywords: Positron Emission Tomography; PET Pharmacokinetics; PET Kinetic Modeling; Neuropharamacological Measurements Using PET; Neuroimaging; PET for Clinical Diagnosis and Drug Discovery; Radiology; Health Sciences
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APA ·
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APA (6th Edition):
Joshi, A. (2008). Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/61729
Chicago Manual of Style (16th Edition):
Joshi, Aniket. “Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies.” 2008. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/61729.
MLA Handbook (7th Edition):
Joshi, Aniket. “Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies.” 2008. Web. 15 Jan 2021.
Vancouver:
Joshi A. Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/61729.
Council of Science Editors:
Joshi A. Improved Quantitative Methods for Multiple Neuropharmacological Non-Invasive Brain PET Studies. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/61729
University of Michigan
5.
Shi, Hugo R.
Fast Regularization Design for Tomographic Image Reconstruction for Uniform and Spatial Resolution.
Degree: PhD, Electrical Engineering: Systems, 2008, University of Michigan
URL: http://hdl.handle.net/2027.42/61554
► Statistical methods for tomographic image reconstruction have improved noise and spatial resolution properties that may improve image quality in X-ray CT and PET. Final converged…
(more)
▼ Statistical methods for tomographic image reconstruction have improved noise and spatial
resolution properties that may improve image quality in X-ray CT and PET. Final
converged solutions from maximum likelihood (ML) and weighted least squares (WLS)
reconstruction are often extremely noisy due to the ill conditioned nature of the system.
One can stop the iterative algorithm before convergence and before images become too
noisy, however this results in non-uniform and anisotropic spatial resolution because resolution
uniformity and isotropy improve with successive iterations. Alternatively, one can
run the iterative algorithm to completion and post-filter the resulting noise, however, this
often requires a large number of iterations. Instead we use penalized likelihood (PL) and
penalized weighted least squares (PWLS) with a roughness penalty to regularize the problem
which filters out noise, and leads to faster convergence. Unfortunately, interactions
between the weightings, which are implicit in PL methods and explicit in PWLS methods,
and conventional quadratic regularization lead to nonuniform and anisotropic spatial resolution.
Previous work focuses on matrix algebra methods to design data-dependent, shift
variant regularizers that improve resolution uniformity. This thesis develops fast analytical
regularization design methods for 2D fan-beam X-ray CT imaging, for which parallelbeam
tomography is a special case. This thesis uses continuous space analogs to greatly
simplify the regularization design problem which yields a mostly analytical solution for
efficient computation. This thesis extends regularization design to 3D systems using a
computationally efficient iterative approach. Finally, this thesis explores using 2D regularization
with z-dimension post-reconstruction denoising. This is an attempt to combine
the improved XY isotropy associated with 2D regularization design, and the computational
efficiency of the mostly analytical solution and use it for 3D geometries. The spatial
resolution and noise properties of this method is analyzed for quadratic regularizers. Simulation
results have also been performed using non-quadratic edge-preserving regularizers
which show that, though this method has potential, more work needs to be done to ensure
that the spatial resolution and noise properties of this method are desirable.
Advisors/Committee Members: Fessler, Jeffrey A. (committee member), Clinthorne, Neal H. (committee member), Meyer, Charles R. (committee member), Sadanandarao, Sandeep P. (committee member).
Subjects/Keywords: Tomographic Reconstruction; Regularization; Iterative Reconstruction; Spatial Resolution; Engineering
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APA ·
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APA (6th Edition):
Shi, H. R. (2008). Fast Regularization Design for Tomographic Image Reconstruction for Uniform and Spatial Resolution. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/61554
Chicago Manual of Style (16th Edition):
Shi, Hugo R. “Fast Regularization Design for Tomographic Image Reconstruction for Uniform and Spatial Resolution.” 2008. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/61554.
MLA Handbook (7th Edition):
Shi, Hugo R. “Fast Regularization Design for Tomographic Image Reconstruction for Uniform and Spatial Resolution.” 2008. Web. 15 Jan 2021.
Vancouver:
Shi HR. Fast Regularization Design for Tomographic Image Reconstruction for Uniform and Spatial Resolution. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/61554.
Council of Science Editors:
Shi HR. Fast Regularization Design for Tomographic Image Reconstruction for Uniform and Spatial Resolution. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/61554
University of Michigan
6.
Zhang, Lisha.
Compton gamma -ray imaging probes for prostate and breast.
Degree: PhD, Medical imaging, 2004, University of Michigan
URL: http://hdl.handle.net/2027.42/124603
► Radionuclide imaging provides valuable functional information that cannot be obtained using anatomical imagers. Consequently, it has been successfully used in detecting tumors and monitoring disease…
(more)
▼ Radionuclide imaging provides valuable functional information that cannot be obtained using anatomical imagers. Consequently, it has been successfully used in detecting tumors and monitoring disease recurrence and response to therapy. However, conventional single photon imaging systems have spatial resolution in the 1 – 2 cm range for imaging objects at distances 8 to 10 cm. It is important to improve spatial resolution in order to detect tumor as early as possible when treatment is more effective. However, conventional imaging system can improve spatial resolution only at the expense of sensitivity and increased statistical image noise. The proposed Compton imaging technique does not require collimators to form images so that sensitivity is decoupled from spatial resolution. Furthermore, Compton imagers have better performance as gamma-ray energy increases in direct contrast to collimator performance. Probes based on the Compton imaging technique can achieve simultaneous high spatial resolution and high sensitivity over a wide range of energies from 141 keV and above. In this thesis, potential Compton probe designs and their performance in prostate and breast imaging are evaluated using data generated by clinical situation. Images reconstructed using EM algorithm are evaluated using both resolution and sensitivity criteria and observer models to predict detection sensitivity. Results show that the proposed prostate imaging probes achieve absolute detection efficiency of 0.17%, a two-order-magnitude improvement over the mechanically collimated systems, and spatial resolution of 2.4 mm FWHM for
111In. An 8 mm tumor with TB ratio of 5:1 is clearly detectable in the reconstructed prostate images, but invisible in the single photon emission computed tomography (SPECT) images. With the same imaging time, the prostate probes have an improved SNR of 3 – 3.5x over the SPECT for detecting both 5 mm and 8 mm tumors. The probe for breast imaging reveals a moderate improvement over a dedicated scintimammographic system in detecting a 5 mm tumor and comparable performance in the detection of an 8 mm tumor.
Advisors/Committee Members: Rogers, W. Leslie (advisor), Clinthorne, Neal H. (advisor).
Subjects/Keywords: Breast Imaging; Compton Gamma-ray Imaging; Gamma-rays; Imaging Probes; Medical Imaging; Prostate Imaging
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APA ·
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APA (6th Edition):
Zhang, L. (2004). Compton gamma -ray imaging probes for prostate and breast. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/124603
Chicago Manual of Style (16th Edition):
Zhang, Lisha. “Compton gamma -ray imaging probes for prostate and breast.” 2004. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/124603.
MLA Handbook (7th Edition):
Zhang, Lisha. “Compton gamma -ray imaging probes for prostate and breast.” 2004. Web. 15 Jan 2021.
Vancouver:
Zhang L. Compton gamma -ray imaging probes for prostate and breast. [Internet] [Doctoral dissertation]. University of Michigan; 2004. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/124603.
Council of Science Editors:
Zhang L. Compton gamma -ray imaging probes for prostate and breast. [Doctoral Dissertation]. University of Michigan; 2004. Available from: http://hdl.handle.net/2027.42/124603
University of Michigan
7.
Sukovic, Predrag.
Design of a dual modality PET/cone beam CT scanner. A feasibility study.
Degree: PhD, Medical imaging, 2003, University of Michigan
URL: http://hdl.handle.net/2027.42/123716
► Positron Emission Tomography (PET) is a noninvasive medical imaging modality that provides quantitative information about human physiology. One of the most rapidly expanding areas of…
(more)
▼ Positron Emission Tomography (PET) is a noninvasive medical imaging modality that provides quantitative information about human physiology. One of the most rapidly expanding areas of PET imaging is cancer diagnosis. The application of PET in cancer diagnosis is, however, hampered by the attenuation of gamma-rays and poor anatomical localization. The attenuation of gamma-rays is typically accounted for by taking a transmission scan with an external gamma-ray source. Radionuclide transmission scans, however, suffer from a high noise level and take a long time to acquire. The second problem – the imprecise anatomical localization of the metabolic changes – is due to the fact that a PET scan contains very little anatomical information. A solution is to superimpose the PET image with a separately obtained X-ray computed tomography (CT) image. Because the two scans are obtained using different scanners with different geometries and protocols, the fusion is not trivial. Also, these methods require expert supervision and are computationally expensive. As another solution, several dual modality PET/CT scanners have recently been developed. These devices, however, are typically very expensive and expose the patient to a high radiation dose. We propose a novel PET/CT design that can be developed at a significantly lower cost and exposes the patient to a lower radiation dose. The CT component is based on cone beam mode of scanning. The cone beam CT (CBCT) scan is used to perform the attenuation correction for the PET scan and is fused with the PET scan to produce a combined anato-metabolic image. We have constructed a CBCT test bench to perform feasibility studies. We successfully performed attenuation correction for a PET scan of a torso phantom and demonstrated that the radiation dose can be significantly lower than in diagnostic CT, while maintaining the quality of the attenuation correction. We further proposed several methods for improving upon the performance of the basic design, to of which we dealt with in more detail. First, we proposed a method for improving the dynamic range of the flat panel detectors. Second, we proposed a statistically motivated dual energy image reconstruction method - DE PWLS.
Advisors/Committee Members: Clinthorne, Neal H. (advisor), Fessler, Jeffrey A. (advisor).
Subjects/Keywords: Cone-beam Ct; Ct Scanner; Design; Dual Modality; Dual-modality; Feasibility; Flat-panel Detector; Flat-panel Detectors; Pet; Study
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APA (6th Edition):
Sukovic, P. (2003). Design of a dual modality PET/cone beam CT scanner. A feasibility study. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/123716
Chicago Manual of Style (16th Edition):
Sukovic, Predrag. “Design of a dual modality PET/cone beam CT scanner. A feasibility study.” 2003. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/123716.
MLA Handbook (7th Edition):
Sukovic, Predrag. “Design of a dual modality PET/cone beam CT scanner. A feasibility study.” 2003. Web. 15 Jan 2021.
Vancouver:
Sukovic P. Design of a dual modality PET/cone beam CT scanner. A feasibility study. [Internet] [Doctoral dissertation]. University of Michigan; 2003. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/123716.
Council of Science Editors:
Sukovic P. Design of a dual modality PET/cone beam CT scanner. A feasibility study. [Doctoral Dissertation]. University of Michigan; 2003. Available from: http://hdl.handle.net/2027.42/123716
. 
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