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You searched for +publisher:"University of KwaZulu-Natal" +contributor:("Moodley, Dhayendre."). Showing records 1 – 2 of 2 total matches.

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University of KwaZulu-Natal

1. Desmond, Alicia Catherine. Evaluation of adherence measures in infants receiving daily nevirapine suspension for prevention of mother-to-child transmission of HIV.

Degree: Pharmacy and pharmocology, 2016, University of KwaZulu-Natal

INTRODUCTION Adherence to antiretroviral treatment regimens in children has been substantially researched, however data pertaining to adherence to prophylactic regimens in the paediatric population, especially infants, is not readily available. As adherence to an antiretroviral treatment regimen is central to ensuring that expected benefits are achieved, adherence to a prophylactic regimen is as important in Human Immunodeficiency Virus (HIV) prevention. The HPTN 046 study was a prospective cohort study conducted from June 2008 to March 2010 in South Africa (Durban), Tanzania, Zimbabwe and Uganda. All enrolled infants received open label nevirapine suspension (10mg/ml) up to 6 weeks of age (day 42), at which point they were randomised to receive nevirapine suspension or placebo till 6 months of age. The dosing regimen for the first 6 weeks was as follows: 0.6ml (6mg) once daily from 3 to 7 days after birth to 2 weeks of age, 1.5ml (15mg) once daily from 2 to5 weeks of age and 1.8ml (18mg) once daily from 5 to 6 weeks (42 days) of age. Adherence to medication can be measured by various methods. The aim of this study was to ascertain the reliability of maternal verbal reports in measuring adherence to antiretroviral prophylaxis in infants in the first 6 weeks of life and evaluating the unused returned medication as an alternative method of measuring adherence. OBJECTIVES: 1. To measure adherence to daily use of nevirapine prophylaxis in infants at 2, 5 and 6 weeks of age by use of maternal verbal reports. 2. To measure adherence to daily use of nevirapine prophylaxis in infants at 2, 5 and 6 weeks of age by assessing the volume of unused returned nevirapine suspension. 3. To compare the sensitivity and specificity of maternal verbal reports and unused returned nevirapine suspension in relation to plasma nevirapine concentration. 4. To describe maternal and infant characteristics in association with adherence as measured by maternal verbal reports. METHODOLOGY: Main study: The HPTN 046 Study Measurement of adherence by maternal verbal reports: Enrolled participants’ mothers were administered a questionnaire regarding infant dosing and number of missed doses. This data was transferred into case report forms and captured into the main HPTN 046 database. Measurement of adherence by assessment of unused returned medication: Mothers of participants were requested by counsellors to return bottles with remaining medication from the previous visit at each subsequent appointment. At the 2 week, 5 week and 6 week visits, unused medication bottles were returned and weighed to determine adherence. The weight was converted to volume using the density formula (mass/volume). The dose taken was calculated by subtracting the returned volume from 20ml (volume of a full bottle). The number of missed doses was calculated from considering the expected volume that should have been taken and the actual volume taken. Substudy: The substudy was a retrospective cohort study of the HPTN 046 study. Measurement of adherence by plasma… Advisors/Committee Members: Moodley, Dhayendre. (advisor).

Subjects/Keywords: Pharmacy and pharmocology.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Desmond, A. C. (2016). Evaluation of adherence measures in infants receiving daily nevirapine suspension for prevention of mother-to-child transmission of HIV. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/12957

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Desmond, Alicia Catherine. “Evaluation of adherence measures in infants receiving daily nevirapine suspension for prevention of mother-to-child transmission of HIV.” 2016. Thesis, University of KwaZulu-Natal. Accessed September 24, 2020. http://hdl.handle.net/10413/12957.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Desmond, Alicia Catherine. “Evaluation of adherence measures in infants receiving daily nevirapine suspension for prevention of mother-to-child transmission of HIV.” 2016. Web. 24 Sep 2020.

Vancouver:

Desmond AC. Evaluation of adherence measures in infants receiving daily nevirapine suspension for prevention of mother-to-child transmission of HIV. [Internet] [Thesis]. University of KwaZulu-Natal; 2016. [cited 2020 Sep 24]. Available from: http://hdl.handle.net/10413/12957.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Desmond AC. Evaluation of adherence measures in infants receiving daily nevirapine suspension for prevention of mother-to-child transmission of HIV. [Thesis]. University of KwaZulu-Natal; 2016. Available from: http://hdl.handle.net/10413/12957

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of KwaZulu-Natal

2. Singh, Michelle. Pharmaco-immunological-virological dynamics in intrapartum HIV-1 transmission (PIVD study).

Degree: PhD, Obstetrics and Gynaecology, 2009, University of KwaZulu-Natal

Background: Multiple factors contribute to mother-to-child transmission (MTCT) of HIV-1, including virological, obstetric and biological factors. Other possible contributory determinants for high MTCT rates include immunological factors such as host genetics and viral genetic variations. Despite several therapeutic, prophylactic and obstetric interventions to reduce the proportion of infants infected during labour and delivery, mechanisms for intrapartum HIV-1 transmission remain elusive and current interventions, could, therefore remain sub-optimal. Much controversy has surrounded the correlation of HIV-1 RNA (viral load) in the systemic and genital compartments of women. The influence of short-term antiretroviral (ARV) drugs on genital tract HIV-1 is also unclear. At the time the present study was initiated, a regimen of maternal intrapartum and neonatal postpartum single-dose Nevirapine (sdNVP) was the standard of care for the prevention of mother-to-child transmission (PMTCT). In most low and middle-income countries, including South Africa, sdNVP has been documented as effective intrapartum HIV-1 prevention based on plasma pharmacokinetic levels, decreased viral loads (HIV-1 RNA) and reduced rates of intrapartum transmission, yet operational studies continue to report high intrapartum transmission rates despite the administration of sdNVP. As a result perinatal HIV-1 transmission remains a significant public health concern in several African countries. Aim: The primary aim of this study was to describe the pharmacological dynamics of Nevirapine in association with virological and immunological risk factors for intrapartum HIV-1 transmission in a South African PMTCT programme where sdNVP was the standard of care. Methods: Following regulatory approval from the Biomedical Research Ethics Committee at the University of KwaZulu-Natal (UKZN), one hundred and twenty pregnant HIV-infected women who received the sdNVP regimen for prevention of mother-to-child HIV-1 transmission were enrolled between April-December 2006 at King Edward VIII Hospital (KEH) in Durban. Blood and cervicovaginal lavage (CVL) samples were collected from women at pre-NVP (during pregnancy) and post-NVP dosing (during labour/delivery). In addition to infant blood sampling at birth (post-NVP), postnatal infants were assessed at four and six weeks postnatally. Pharmacological laboratory investigations involved measurement of NVP drug concentration by Tandem Mass spectrophotometry. Virological investigations comprised HIV-1 RNA (viral load) quantitation, HIV-1 drug resistance testing (HIV-1 transmitting women only) and HIV-1 DNA PCR testing (infants only). Immunological investigations were only undertaken in a selected case-control subset of HIV-1 transmitting women and their infants. In this component, laboratory investigations included the determination of CCL3 and CCL3-L1 gene copy numbers, identification of single nucleotide polymorphisms (SNP’s) and haplotype characterisation of the CCL3 gene. All women were also screened for the presence of… Advisors/Committee Members: Moodley, Dhayendre. (advisor), Moodley, Jagidesa. (advisor).

Subjects/Keywords: Obstetrics and Gynaecology.

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Singh, M. (2009). Pharmaco-immunological-virological dynamics in intrapartum HIV-1 transmission (PIVD study). (Doctoral Dissertation). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/686

Chicago Manual of Style (16th Edition):

Singh, Michelle. “Pharmaco-immunological-virological dynamics in intrapartum HIV-1 transmission (PIVD study).” 2009. Doctoral Dissertation, University of KwaZulu-Natal. Accessed September 24, 2020. http://hdl.handle.net/10413/686.

MLA Handbook (7th Edition):

Singh, Michelle. “Pharmaco-immunological-virological dynamics in intrapartum HIV-1 transmission (PIVD study).” 2009. Web. 24 Sep 2020.

Vancouver:

Singh M. Pharmaco-immunological-virological dynamics in intrapartum HIV-1 transmission (PIVD study). [Internet] [Doctoral dissertation]. University of KwaZulu-Natal; 2009. [cited 2020 Sep 24]. Available from: http://hdl.handle.net/10413/686.

Council of Science Editors:

Singh M. Pharmaco-immunological-virological dynamics in intrapartum HIV-1 transmission (PIVD study). [Doctoral Dissertation]. University of KwaZulu-Natal; 2009. Available from: http://hdl.handle.net/10413/686

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