+publisher:"University of Illinois – Chicago" +contributor:("Walton, Surrey M.")

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University of Illinois – Chicago

1. Bathija, Sacheeta. Patient Outcomes with Warfarin Therapy after Hip and Knee Replacement: Comparison of Two Models of Care.

Degree: 2013, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/10042

► The first objective of the study was to examine the association between race of the patients and their referral to anticoagulation clinic compared to orthopedic… (more)

▼ The first objective of the study was to examine the association between race of the patients and their referral to anticoagulation clinic compared to orthopedic clinic for venous thromboembolism prophylaxis (VTE) post-surgery. The second objective was to compare time in therapeutic range (TTR) in patients receiving warfarin therapy between anticoagulation clinic and orthopedic clinic. We conducted a retrospective, observational study of patients who underwent hip or knee replacement surgery at University of Illinois Hospital and Health Sciences System (UIHHSS) between the years 2000 and 2009 and were referred to either anticoagulation clinic or orthopedic clinic at UIHHSS for post-surgical prophylaxis. There were 294 patients referred to anticoagulation clinic and 573 to orthopedic clinic. The majority of the study cohort patients were female (68.3%) and average age of the cohort was 59 years. Compared to Caucasians, African Americans (ORadj=1.543, 95% CI =0.929-2.563) and Hispanics (ORadj=4.244, 95% CI =2.378-7.574) were more likely to be referred to anticoagulation clinic whereas others (ORadj=0.164, 95% CI =0.050-0.545) were less likely to be referred to anticoagulation clinic adjusting for the covariates. The adjusted mean TTR was 8.96% higher after matching on propensity scores, 8.79% higher after matching covariates, 9.02% higher after applying inverse probability weighting and 9.08% higher after applying inverse probability weighting combined with regression adjustment for patients receiving warfarin prophylaxis at anticoagulation clinic. For the overall group, the adjusted mean TTR was 6.60% higher after applying inverse probability weighting and 7.1% higher after applying inverse probability weighting combined with regression adjustment for those referred to anticoagulation clinic compared to those referred to orthopedic clinic. Our study adds to the existing body of literature on anticoagulation models of care for patients receiving warfarin therapy. We found that race adjusting for covariates influenced the patient referral pattern to outpatient clinics for receiving post surgery prophylaxis. In addition, we found that patients in anticoagulation clinic have a higher TTR for receiving a short term VTE prophylaxis compared to routine model of care. Future research is needed to understand the impact of anticoagulation care in a larger diverse sample of patients receiving warfarin therapy. Advisors/Committee Members: Walton, Surrey M. (advisor), Lau, Denys (committee member), Nutescu, Edith (committee member).

Subjects/Keywords: warfarin; anticoagulation; propensity scores; venous thromboembolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bathija, S. (2013). Patient Outcomes with Warfarin Therapy after Hip and Knee Replacement: Comparison of Two Models of Care. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/10042

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bathija, Sacheeta. “Patient Outcomes with Warfarin Therapy after Hip and Knee Replacement: Comparison of Two Models of Care.” 2013. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/10042.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bathija, Sacheeta. “Patient Outcomes with Warfarin Therapy after Hip and Knee Replacement: Comparison of Two Models of Care.” 2013. Web. 04 Mar 2021.

Vancouver:

Bathija S. Patient Outcomes with Warfarin Therapy after Hip and Knee Replacement: Comparison of Two Models of Care. [Internet] [Thesis]. University of Illinois – Chicago; 2013. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/10042.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bathija S. Patient Outcomes with Warfarin Therapy after Hip and Knee Replacement: Comparison of Two Models of Care. [Thesis]. University of Illinois – Chicago; 2013. Available from: http://hdl.handle.net/10027/10042

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

2. Grant, Mark D. Three Stories of Ischemic Stroke: Aging Dependence, Carotid Procedures, and Asymptomatic Carotid Disease.

Degree: 2014, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/11216

► Aging-dependent diseases are largely a consequence of the underlying chronic degenerative accompaniments of aging with incidences expected to increase exponentially with age. Ischemic stroke should… (more)

▼ Aging-dependent diseases are largely a consequence of the underlying chronic degenerative accompaniments of aging with incidences expected to increase exponentially with age. Ischemic stroke should be aging because much of the underlying pathology is a consequence of aging. National Hospital Discharge Survey (NHDS) from 1970 to 2009 were analyzed to define secular trends in sex- and age-specific ischemic stroke incidence. Over the 40 years, sex-specific distributions demonstrated exponentially increasing ischemic stroke incidence with age supporting the notion of ischemic stroke as an aging-dependent disease. Using NHDS data we next examined carotid endarterectomies (CEA) performed in the United States from 1970 through 2010, and the recent introduction of carotid angioplasty and stenting (CAS). Two substantial rises in CEA rates followed by subsequent falls were evident over the four decades. Adoption of CAS was limited. Juxtaposing rates against highly cited studies suggests enthusiasm driven increases tempered by observational study and trial results. Lastly, we examined the potential benefit of CEA for asymptomatic patients in the setting of improved medical care since completion of the Asymptomatic Carotid Surgery Trial in 2004. Nine studies were identified reporting ipsilateral stroke rates in patients with asymptomatic carotid disease published after 2004. Seven included patients who were not likely candidates for CEA. Other biases were prominent in all but one study. The pooled annual ipsilateral stroke rate was 0.98% (95% Credible Interval [CrI]: 0.54 to 1.57); excluding the three most biased studies 1.36% (95% CrI: 0.88 to 1.83). The best estimate of ipsilateral stroke incidence in patients with significant asymptomatic carotid stenosis is somewhat greater than 1%. Using a Monte Carlo approach, we then synthesized evidence and combined it with decision models to compare CEA outcomes with contemporary medical care. Estimates from Bayesian meta-analyses of ipsilateral stroke rates and relative risk reduction of stroke following CEA were incorporated in Markov cohort models over a five-year time horizon. Compared with medical care, to gain expected quality adjusted life years, periprocedural CEA mortality must approach 0% with stroke rates lower than 1.5%. Advisors/Committee Members: Freeman, Vincent L. (advisor), Stayner, Leslie T. (committee member), Persky, Victoria W. (committee member), Karabatsos, George (committee member), Walton, Surrey M. (committee member).

Subjects/Keywords: aging; epidemiology; carotid atherosclerosis; carotid endarterectomy; carotid angioplasty and stenting; decision modeling; meta-analysis; evidence synthesis

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APA (6^th Edition):

Grant, M. D. (2014). Three Stories of Ischemic Stroke: Aging Dependence, Carotid Procedures, and Asymptomatic Carotid Disease. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/11216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grant, Mark D. “Three Stories of Ischemic Stroke: Aging Dependence, Carotid Procedures, and Asymptomatic Carotid Disease.” 2014. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/11216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grant, Mark D. “Three Stories of Ischemic Stroke: Aging Dependence, Carotid Procedures, and Asymptomatic Carotid Disease.” 2014. Web. 04 Mar 2021.

Vancouver:

Grant MD. Three Stories of Ischemic Stroke: Aging Dependence, Carotid Procedures, and Asymptomatic Carotid Disease. [Internet] [Thesis]. University of Illinois – Chicago; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/11216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grant MD. Three Stories of Ischemic Stroke: Aging Dependence, Carotid Procedures, and Asymptomatic Carotid Disease. [Thesis]. University of Illinois – Chicago; 2014. Available from: http://hdl.handle.net/10027/11216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

3. Carson, Kenneth R. Evaluation of Racial Disparities in United States Veterans with Diffuse Large B-Cell Lymphoma.

Degree: 2015, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/19368

► There is a well-described, race-based outcome disparity in patients diagnosed with the most common form of non-Hodgkin lymphoma, diffuse large B-cell lymphoma. Despite significant speculation… (more)

▼ There is a well-described, race-based outcome disparity in patients diagnosed with the most common form of non-Hodgkin lymphoma, diffuse large B-cell lymphoma. Despite significant speculation regarding the sources of this disparity, few firm conclusions have been drawn. Using data from the United States Veterans Health Administration, a cohort was constructed of 3,227 patients with a new diagnosis of diffuse large B-cell lymphoma made between October 1, 1998 and September 30, 2008. Consistent with previous studies, black patients had poorer overall survival, were younger, and more likely to have advanced stage disease compared to white patients. New findings from this study were a higher prevalence of HIV in black patients compared to white patients (21% versus 4%, p <.0001), and higher frequency elevated lactate dehydrogenase (64% versus 54%, respectively, p=.003), a serum tumor marker. Cox analysis controlling for differences in baseline characteristics noted between the black and white patients demonstrated that patients who were HIV positive had a markedly increased risk of death (hazard ratio=1.67, 95% confidence interval 1.27–2.2). Treatment variables associated with a reduced risk of death included: doxorubicin (hazard ratio=.57, 95% confidence interval 0.49–0.67), rituximab (hazard ratio=.6, 95% confidence interval 0.52–0.69), and myeloid growth factors (hazard ratio=.74, 95% confidence interval 0.56–0.98). Logistic regression analyses demonstrated no race-based differences in the use of doxorubicin, rituximab, or myeloid growth factors. While univariate analyses suggested decreased rituximab use in black patients, multivariable analysis demonstrated that this was driven by the differences in HIV prevalence. Patients who were HIV positive were less likely to receive rituximab (odds ratio=.1, 95% confidence interval 0.06–0.18), consistent with standard of care practice during the study time frame. Taken together, these results demonstrate that a higher prevalence of HIV in black patients is an important factor in racial outcome disparities in diffuse large B-cell lymphoma. There was no evidence of systematic bias in the application of curative intent therapy after controlling for HIV status. Measures to prevent or control HIV may be the best way to reduce racial disparities in diffuse large B-cell lymphoma. Advisors/Committee Members: Calhoun, Elizabeth A. (advisor), Colditz, Graham A. (committee member), Crawford, Stephanie Y. (committee member), Gann, Peter H. (committee member), Walton, Surrey M. (committee member).

Subjects/Keywords: Lymphoma; Disparities; Treatment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carson, K. R. (2015). Evaluation of Racial Disparities in United States Veterans with Diffuse Large B-Cell Lymphoma. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19368

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carson, Kenneth R. “Evaluation of Racial Disparities in United States Veterans with Diffuse Large B-Cell Lymphoma.” 2015. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/19368.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carson, Kenneth R. “Evaluation of Racial Disparities in United States Veterans with Diffuse Large B-Cell Lymphoma.” 2015. Web. 04 Mar 2021.

Vancouver:

Carson KR. Evaluation of Racial Disparities in United States Veterans with Diffuse Large B-Cell Lymphoma. [Internet] [Thesis]. University of Illinois – Chicago; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/19368.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carson KR. Evaluation of Racial Disparities in United States Veterans with Diffuse Large B-Cell Lymphoma. [Thesis]. University of Illinois – Chicago; 2015. Available from: http://hdl.handle.net/10027/19368

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

4. Patel, Vardhaman. Direct Thrombin Inhibitors: Use and Consequences in Patients with Heparin-Induced Thrombocytopenia.

Degree: 2015, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/19794

► Heparin-induced thrombocytopenia (HIT) is an immunologic response to heparin exposure that may lead to thrombosis. Argatroban and bivalirudin are two commonly used direct thrombin inhibitors… (more)

▼ Heparin-induced thrombocytopenia (HIT) is an immunologic response to heparin exposure that may lead to thrombosis. Argatroban and bivalirudin are two commonly used direct thrombin inhibitors (DTIs) for the prevention of thrombosis in patients with HIT. However, DTIs may lead to major bleeding events. Data on the use and consequences of DTIs is limited. Of note, patients with suspected HIT are of interest in the thesis, as current guidelines recommend the initiation of DTI treatment at the time of clinical suspicion of HIT. This thesis focused on the identification of suspected HIT, and the use and consequences of direct thrombin inhibitors (DTI) for the treatment of suspected HIT. First, algorithms based on diagnostic codes, medications and diagnostic tests were developed and validated to identify patients with suspected HIT. An algorithm based only on the timing of medication and diagnostic tests was recommended for the identification of suspected HIT from claims data, as it was observed to have the highest positive predictive value and sensitivity. Second, the rates of thrombosis, major bleeding, amputation and mortality were compared between argatroban-treated and bivalirudin-treated patients using administrative claims data obtained from the University HealthSystem Consortium. The difference in the likelihood of thrombosis, amputation and mortality between the two DTI groups was not statistically significant. However, bivalirudin-treated patients were more likely to experience major bleeding than argatroban-treated patients. Third, the use of bivalirudin for the treatment of suspected HIT (off-label use) increased from one-third to half of DTI-treated patients from 2010 to 2012. Patients treated by surgeons or specialists were more likely to receive off-label bivalirudin compared to patients treated by primary care. In addition, hepatic impairment and skin infection increased the odds of patients to receive bivalirudin over argatroban. In conclusion, the off-label use of bivalirudin should be scrutinized for medical necessity due to the higher risk of bleeding than argatroban, except in patients with hepatic impairment. Advisors/Committee Members: Walton, Surrey M. (advisor), Schumock, Glen T. (committee member), Lee, Todd A. (committee member), Galanter, William L. (committee member), Nutescu, Edith A. (committee member), Hohmann, Samuel F. (committee member).

Subjects/Keywords: 1; comparative effectiveness; 2; direct thrombin inhibitors; 3; argatroban; 4; bivalirudin; 5; thrombosis; 6; major bleeding; 7; safety; 8; off-label; 9; algorithms; 10; validity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patel, V. (2015). Direct Thrombin Inhibitors: Use and Consequences in Patients with Heparin-Induced Thrombocytopenia. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Patel, Vardhaman. “Direct Thrombin Inhibitors: Use and Consequences in Patients with Heparin-Induced Thrombocytopenia.” 2015. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/19794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Patel, Vardhaman. “Direct Thrombin Inhibitors: Use and Consequences in Patients with Heparin-Induced Thrombocytopenia.” 2015. Web. 04 Mar 2021.

Vancouver:

Patel V. Direct Thrombin Inhibitors: Use and Consequences in Patients with Heparin-Induced Thrombocytopenia. [Internet] [Thesis]. University of Illinois – Chicago; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/19794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Patel V. Direct Thrombin Inhibitors: Use and Consequences in Patients with Heparin-Induced Thrombocytopenia. [Thesis]. University of Illinois – Chicago; 2015. Available from: http://hdl.handle.net/10027/19794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

5. Kim, Kibum. Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome.

Degree: 2016, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21293

► In patients who have received percutaneous coronary intervention (PCI) for the treatment of acute coronary syndrome (ACS), three anti-platelet agents were similarly used to reduce… (more)

▼ In patients who have received percutaneous coronary intervention (PCI) for the treatment of acute coronary syndrome (ACS), three anti-platelet agents were similarly used to reduce further cardiovascular complications. Of them the newer agents, prasugrel and ticagrelor, showed better efficacy profiles in a controlled setting compared to clopidogrel. With regard to the real-world practice in the anti-platelet agent use, however, there has been limited evidence. This research project was designed to fill in the research gap using an insurance claims database. During the period between 2009 and 2013, clopidogrel use remained a dominant option in commercially insured ACS-PCI patients, especially in patients with risk factors of further complication. After being launched, ticagrelor did not take up the US market share of clopidogrel, but instead replaced prasugrel. Clopidogrel use was significantly associated with the presence of comorbid conditions or risks of future complications and mortality. The odds of using ticagrelor vs. prasugrel increased with a history of cerebrovascular events. Selection of anti-platelet agent was not associated with a significant difference in total medical expenditure. Treatment effects on economic outcomes were separately measured in patients who enrolled in the health plan over a 6-month post ACS discharge period and in those who maintained their initial treatment over the 6 months. Regression analyses found that the use of newer agents vs. clopidogrel increased medication cost over the 6-month period, which is mainly attributed to the increase in the expenditure on the cardiovascular medication. However, when we looked at the total medical cost, the estimated difference between the costs in the newer agent users and in the clopidogrel users was insignificant. The analysis of resource utilization demonstrated that there was a significant decrease in the rate of hospital admission with the use of newer agents, which explained how the increase in the medication cost could be cancelled out. Between prasugrel and ticagrelor, there was not a statistically significant difference in the hazard rates of all-cause and MI related hospitalization from 30-day to 365-day post ACS-PCI discharge periods. The hazard ratios were corresponding to the effect of drug selection on healthcare utilization estimates. In general, association measures did not consistently favor one over the other. Although the results and conclusions were accompanied by the general limitations of retrospective analysis and suffered from sample size issues, the study helped to fill a gap which have not been and could not be investigated in a controlled setting. Advisors/Committee Members: Walton, Surrey M. (advisor), Lee, Todd A. (committee member), Touchette, Daniel R. (committee member), Ardati, Amer K. (committee member), DiDomenico, Robert J. (committee member).

Subjects/Keywords: Ticagrelor; Prasugrel; Clopidogrel; Outcomes; Acute Coronary Syndrome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, K. (2016). Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21293

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, Kibum. “Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome.” 2016. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/21293.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, Kibum. “Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome.” 2016. Web. 04 Mar 2021.

Vancouver:

Kim K. Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/21293.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim K. Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/21293

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

6. Jalundhwala, Yash J. The Role of Health-Related Lifestyle Attitudes in Understanding Health Behaviors and Outcomes.

Degree: 2016, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21586

► Health systems throughout the world increasingly recognize health-related quality of life (HRQoL) as a key patient-centered health outcome. HRQoL is particularly important in conditions which… (more)

▼ Health systems throughout the world increasingly recognize health-related quality of life (HRQoL) as a key patient-centered health outcome. HRQoL is particularly important in conditions which impair daily living (e.g. Parkinson’s Disease) and in those that are largely subjective in nature (e.g. pain). HRQoL, when assessed using a preference-based measure, is an essential component in the calculation of quality adjusted life years (QALYs). QALYs gained form the denominator in an incremental cost-effectiveness ratio (ICER), which is the most common result derived in a cost-utility analysis and is used to inform patient and system-level decisions and incorporated into pricing and reimbursement decisions. HRQoL can be viewed as an individual’s perception of his/her own health. An individual’s perception is often influenced by attitudes and beliefs, which in turn also influence health behaviors and overall health. This dissertation examines the role of health and life-style related attitudes (HLA) in understanding health behaviors and outcomes through three separate studies. The studies evaluated the validity of measures of HRQoL and HLA in a community population and examined the relationship between HLA and health behaviors, self-assessment of health and life-satisfaction. The first chapter introduces key study concepts including HLA, self-assessment and life-satisfaction along with a conceptual framework that facilitates the understanding of the relationship between HLA, health behaviors and outcomes (including self-assessment of health and life satisfaction). The introductory chapter highlights the gaps in the evidence, research objectives and hypotheses that were examined in subsequent chapters, and explains the significance of the research. All the studies are based on secondary analyses from a large scale community health study conducted in Kirklees, United Kingdom, in 2012. The second chapter examines the properties of the recently developed EQ-5D-5L as a measure of population health in a large community-based survey. The assessment of the construct validity of the EQ-5D-5L in a community sample helps to facilitate in the use of EQ-5D-5L in general population health studies. A secondary aim of the study was to compare EQ-5D-5L summary scores based on an English value set (5L-ENG), crosswalk scores based on 3L values (XW), and scores based on equal weighting (5L-EWS). Properties of the EQ-5D-5L that were examined included discriminative ability, strength of correlations with related measures of health, and statistical efficiency, as assessed with relative efficiency (RE) ratios between summary scores from known group comparisons, using the XW as the referent. Correlations between EQ-5D dimensions and other measures of health ranged from r =0.56-0.73. Compared to the XW, the RE of the 5L-ENG and 5L-EWS were similar or higher (Age:RE5L-ENG=0.96,RE5L-EWS=1.36; BMI:RE5L-ENG=1.00,RE5L-EWS=1.0; Number of prescription medications:RE5L-ENG=1.00,RE5L-EWS=1.18; Number of Chronic conditions:RE5L-ENG=1.00,RE5L-EWS=1.61; General… Advisors/Committee Members: Pickard , Simon A (advisor), Walton , Surrey M (committee member), Schumock , Glen T (committee member), Sharp , Lisa K (committee member), Caskey , Rachel K (committee member), Pickard , Simon A (chair).

Subjects/Keywords: health-related quality of life; health attitudes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jalundhwala, Y. J. (2016). The Role of Health-Related Lifestyle Attitudes in Understanding Health Behaviors and Outcomes. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21586

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jalundhwala, Yash J. “The Role of Health-Related Lifestyle Attitudes in Understanding Health Behaviors and Outcomes.” 2016. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/21586.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jalundhwala, Yash J. “The Role of Health-Related Lifestyle Attitudes in Understanding Health Behaviors and Outcomes.” 2016. Web. 04 Mar 2021.

Vancouver:

Jalundhwala YJ. The Role of Health-Related Lifestyle Attitudes in Understanding Health Behaviors and Outcomes. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/21586.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jalundhwala YJ. The Role of Health-Related Lifestyle Attitudes in Understanding Health Behaviors and Outcomes. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/21586

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

7. Manzoor, Beenish S. Navigating Safety of Anticoagulant Use From Precision Medicine to Direct Oral Anticoagulants.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/22225

► Background: This dissertation focuses on assessing avenues for safe delivery of oral anticoagulants. In that, three studies have been undertaken to address gaps in practice… (more)

▼ Background: This dissertation focuses on assessing avenues for safe delivery of oral anticoagulants. In that, three studies have been undertaken to address gaps in practice pertaining to Vitamin K Antagonist (VKA) and direct-acting anticoagulant (DOAC) delivery using a mixed-methods approach. More specifically, we identified factors influencing pharmacogenetic (PGx) testing implementation into routine clinical care and assessed utilization patterns (adherence, persistence and transitions) among DOAC initiators Methods: Individual, face-to-face, semi-structured interviews were conducted with healthcare providers at an urban academic medical center to identify factors influencing PGx testing. Transcripts were analyzed thematically using constant comparison. Additionally, to assess utilization patterns in DOAC initiators, Truven Health MarketScan® Commercial and Medicare Supplemental databases were used (2009-2013). Atrial fibrillation (AF) patients newly initiating a DOAC with a minimum of 6 months of continuous health plan enrollment pre and post-index date were included in the cohort. DOAC adherence was measured as proportion of days covered (PDC). Results: Among 38 interviewees, 21 (55.3%) physicians and 17 (44.7%) pharmacists participated. Factors found to influence provider selection of PGx testing were perceptions related to the clinical utility of the PGx test, lack of comfort in interpretation of the test and lack of knowledge related to PGx. Among 66,090 DOAC users, adherence and persistence declined over time, but both declined in a greater magnitude for anticoagulant (AC) naïve compared to AC experienced. The mean PDC in AC naïve and non-AC naïve patients at 6 and 12 months was 72.3% vs. 83.3% (p<0.001) and 63.7% vs. 79.9% (p<0.001), respectively. Additionally, AC naïve user status was a predictor of lower adherence. Lastly, in a cohort of 34,022 AC naïve users, 6,613 (19.4) switched from their index DOAC. Of those that switched, 2912 (44.0%) switched to an alternate DOAC and 2,945 (44.5%) to warfarin. Interestingly, 48.3% patients switch within 6 months of therapy initiation. Conclusion: This dissertation presents timely studies focusing on contemporary practice in antithrombotic therapy. Addressing barriers to implementation of practice modalities such as PGx testing by increasing provider comfort, confidence and knowledge as well as providing enhanced, structured educational support to patients using DOACs are solutions to navigating safety in this evolving landscape. Advisors/Committee Members: Nutescu, Edith A (advisor), Sharp, Lisa K (committee member), Walton, Surrey M (committee member), Lee, Todd A (committee member), Galanter, William L (committee member), Nutescu, Edith A (chair).

Subjects/Keywords: anticoagulants; anticoagulation; safety; warfarin; dabigatran; rivaroxaban; apixaban; direct oral anticoagulants; pharmacogenetics; adherence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Manzoor, B. S. (2017). Navigating Safety of Anticoagulant Use From Precision Medicine to Direct Oral Anticoagulants. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Manzoor, Beenish S. “Navigating Safety of Anticoagulant Use From Precision Medicine to Direct Oral Anticoagulants.” 2017. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/22225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Manzoor, Beenish S. “Navigating Safety of Anticoagulant Use From Precision Medicine to Direct Oral Anticoagulants.” 2017. Web. 04 Mar 2021.

Vancouver:

Manzoor BS. Navigating Safety of Anticoagulant Use From Precision Medicine to Direct Oral Anticoagulants. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/22225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Manzoor BS. Navigating Safety of Anticoagulant Use From Precision Medicine to Direct Oral Anticoagulants. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

8. Law, Ernest H. Examining Sources Of Variation In Developing A Societal Health State Value Set.

Degree: 2018, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/23037

► This dissertation aimed to examine sources of variation in developing a societal value set for health preferences using a generic preference-based measure. Three separate studies… (more)

▼ This dissertation aimed to examine sources of variation in developing a societal value set for health preferences using a generic preference-based measure. Three separate studies were conducted to assess the differences due to differences in the descriptive system, time, and advance directives status. The first study sought to compare and contrast EQ-5D-5L (‘5L’) and EQ-5D-3L (‘3L’) societal value sets derived from a common sample. Compared to the 3L, value sets developed using the 5L exhibit a lower ceiling effect and improved measurement properties. There was a larger range of scale for the 3L compared to 5L; however, this difference was driven by differences in preference for the most severe level of problems in Mobility for the 3L (“confined to bed”) and 5L (“unable to walk about”). The second study aimed to better understand the implications of informed preferences and examined the association between advance directives for health care and health preferences. Advance directive completion was associated with lower values, implying greater willingness to trade years of life for better health, but not an increased likelihood of valuing health states as WTD. If advance directives are an indicator of a substantial proportion of the population with “informed” preferences, it has implications not only for intensive care decision making at the individual level, but also resource allocation based on cost-utility analysis at the group level. The final study assessed whether there were time-specific differences in health preferences between 2002 and 2017, accounting for demographic changes in the society as well as study designs. Health values in 2017 were modestly higher, implying individuals in 2017 were generally less willing to trade quantity for quality of life compared to 2002. The findings suggest that the era in which values were elicited may be an important reason to consider updating societal value sets. Overall, the work reported in this dissertation advances our understanding of how societal preferences can vary and will be important for informing health technology assessment, health care resource allocation decisions, and understanding how specific groups in society value health. Advisors/Committee Members: Pickard, A. Simon (advisor), Lee, Todd A (committee member), Walton, Surrey M (committee member), Schwartz, Alan (committee member), Xie, Feng (committee member), Pickard, A. Simon (chair).

Subjects/Keywords: health preferences; societal values; health-related quality of life; EQ-5D; advance directives

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Law, E. H. (2018). Examining Sources Of Variation In Developing A Societal Health State Value Set. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Law, Ernest H. “Examining Sources Of Variation In Developing A Societal Health State Value Set.” 2018. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/23037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Law, Ernest H. “Examining Sources Of Variation In Developing A Societal Health State Value Set.” 2018. Web. 04 Mar 2021.

Vancouver:

Law EH. Examining Sources Of Variation In Developing A Societal Health State Value Set. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/23037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Law EH. Examining Sources Of Variation In Developing A Societal Health State Value Set. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/23037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

9. Lin, Fang-Ju. Condition Specific Applications for the Valuation of Health.

Degree: 2013, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/10312

► The research included in this dissertation focused on exploiting different approaches to apply and to improve the use of generic health-related quality of life (HRQL)… (more)

▼ The research included in this dissertation focused on exploiting different approaches to apply and to improve the use of generic health-related quality of life (HRQL) measures in disease- or condition-specific situations. Four separate projects were undertaken to evaluate the measurement properties, strengths and limitations of both generic and disease-specific measures of HRQL, and to estimate patient (experience)-based value sets for a health classifier system. The first of study evaluated the extent of unique content covered by disease-specific preference-based measures when contrasted with the EQ-5D, and identified potential dimensional extensions that may be justified to be added to EQ-5D for various disease-specific applications. The second study examined the properties of several recently developed generic HRQL measures, the Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and five-level EQ-5D (EQ-5D-5L), in patients with chronic obstructive pulmonary disease (COPD), and found evidence to support their validity and reliability. The third study utilized health systems level data to examine the relationship between EQ-5D index and EQ-5D Visual Analogue Scale (EQ-VAS), and Oxford Knee Score (OKS) in patients undergoing knee replacement. We found that EQ-VAS systematically differs from the OKS and EQ-index as an indicator of surgical outcome, but captures unique but valid information about how patients feel about their health. The final study derived patient-based EQ-5D value sets using VAS from patients who experienced knee replacement surgery. Both before and after surgery, larger preference weights were assigned to anxiety/depression and self-care. Greater value decrements were given for health problems after knee replacement compared to before surgery. This time-related shift in values could be a consequence of a gap between experience and expectations of surgery and requires further research, particularly if patient-based value sets are used to inform medical decision making about surgery. Advisors/Committee Members: Pickard, A. Simon (advisor), Lee, Todd A. (advisor), Lee, Todd A. (committee member), Joo, Min J. (committee member), Lambert, Bruce L. (committee member), Walton, Surrey M. (committee member).

Subjects/Keywords: health-related quality of life; preferences; EQ-5D; generic measures; disease-specific measures

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, F. (2013). Condition Specific Applications for the Valuation of Health. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/10312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, Fang-Ju. “Condition Specific Applications for the Valuation of Health.” 2013. Thesis, University of Illinois – Chicago. Accessed March 04, 2021. http://hdl.handle.net/10027/10312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, Fang-Ju. “Condition Specific Applications for the Valuation of Health.” 2013. Web. 04 Mar 2021.

Vancouver:

Lin F. Condition Specific Applications for the Valuation of Health. [Internet] [Thesis]. University of Illinois – Chicago; 2013. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10027/10312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin F. Condition Specific Applications for the Valuation of Health. [Thesis]. University of Illinois – Chicago; 2013. Available from: http://hdl.handle.net/10027/10312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations