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You searched for +publisher:"University of Illinois – Chicago" +contributor:("Touchette, Daniel R"). Showing records 1 – 3 of 3 total matches.

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University of Illinois – Chicago

1. Kim, Kibum. Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome.

Degree: 2016, University of Illinois – Chicago

In patients who have received percutaneous coronary intervention (PCI) for the treatment of acute coronary syndrome (ACS), three anti-platelet agents were similarly used to reduce further cardiovascular complications. Of them the newer agents, prasugrel and ticagrelor, showed better efficacy profiles in a controlled setting compared to clopidogrel. With regard to the real-world practice in the anti-platelet agent use, however, there has been limited evidence. This research project was designed to fill in the research gap using an insurance claims database. During the period between 2009 and 2013, clopidogrel use remained a dominant option in commercially insured ACS-PCI patients, especially in patients with risk factors of further complication. After being launched, ticagrelor did not take up the US market share of clopidogrel, but instead replaced prasugrel. Clopidogrel use was significantly associated with the presence of comorbid conditions or risks of future complications and mortality. The odds of using ticagrelor vs. prasugrel increased with a history of cerebrovascular events. Selection of anti-platelet agent was not associated with a significant difference in total medical expenditure. Treatment effects on economic outcomes were separately measured in patients who enrolled in the health plan over a 6-month post ACS discharge period and in those who maintained their initial treatment over the 6 months. Regression analyses found that the use of newer agents vs. clopidogrel increased medication cost over the 6-month period, which is mainly attributed to the increase in the expenditure on the cardiovascular medication. However, when we looked at the total medical cost, the estimated difference between the costs in the newer agent users and in the clopidogrel users was insignificant. The analysis of resource utilization demonstrated that there was a significant decrease in the rate of hospital admission with the use of newer agents, which explained how the increase in the medication cost could be cancelled out. Between prasugrel and ticagrelor, there was not a statistically significant difference in the hazard rates of all-cause and MI related hospitalization from 30-day to 365-day post ACS-PCI discharge periods. The hazard ratios were corresponding to the effect of drug selection on healthcare utilization estimates. In general, association measures did not consistently favor one over the other. Although the results and conclusions were accompanied by the general limitations of retrospective analysis and suffered from sample size issues, the study helped to fill a gap which have not been and could not be investigated in a controlled setting. Advisors/Committee Members: Walton, Surrey M. (advisor), Lee, Todd A. (committee member), Touchette, Daniel R. (committee member), Ardati, Amer K. (committee member), DiDomenico, Robert J. (committee member).

Subjects/Keywords: Ticagrelor; Prasugrel; Clopidogrel; Outcomes; Acute Coronary Syndrome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kim, K. (2016). Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21293

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kim, Kibum. “Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome.” 2016. Thesis, University of Illinois – Chicago. Accessed February 25, 2021. http://hdl.handle.net/10027/21293.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kim, Kibum. “Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome.” 2016. Web. 25 Feb 2021.

Vancouver:

Kim K. Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10027/21293.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim K. Insight into the Use and Outcomes of Anti-Platelet Agents in Patients with Acute Coronary Syndrome. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/21293

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Illinois – Chicago

2. Xing, Shan. Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes.

Degree: 2017, University of Illinois – Chicago

This dissertation evaluated the use of and comparative effects of second generation antipsychotics (SGAs) and non-SGA depression pharmacotherapies [bupropion, lithium, mirtazapine, tricyclic antidepressants (TCAs) and thyroid hormone] on diabetes outcomes in patients with pre-existing diabetes and depression who previously used a selective serotonin reuptake inhibitor or selective norepinephrine reuptake inhibitor. Three clinical studies compared 1) non-adherence and non-persistence to SGA versus non-SGA depression therapies, 2) non-adherence and non-persistence to oral antidiabetic drugs (OAD) between SGA and non-SGA users, and 3) SGA and non-SGA users on the risk of diabetes-related hospitalization or diabetes drug intensification. Use of SGAs was associated with a 1.8 times higher odds of non-adherence and a 1.4 times higher risk of non-persistence to therapy compared to non-SGA use. Also, SGA users had a 30-40% higher odds of a 10% or greater decline in OAD adherence compared to non-SGA users, while persistence to OAD therapy was similar between groups. Risk of diabetes of diabetes-related hospitalization or diabetes drug intensification was no different comparing SGA versus non-SGA users; however, there were differences when comparing specific treatment subgroups: bupropion was associated with a 15% reduced risk of diabetes-related hospitalization or treatment intensification compared to TCAs, quetiapine was associated with a 18% reduced risk of events compared to mirtazapine, and quetiapine was associated with a 16% reduced risk of events compared to TCAs. Differences for other subgroup comparisons between aripiprazole, quetiapine, bupropion, mirtazapine and TCAs were small and non-significant. Future studies are needed to access the impact of SGA and non-SGA therapies on other diabetes outcomes, including hemoglobin A1c, diabetic complications, and mortality. A fourth methodological study assessed the performance of full-cohort high dimensional propensity score (HDPS) matching approaches versus subgroup-specific HDPS approaches. The full-cohort HDPS matching approaches sometimes resulted in non-overlapping propensity score distributions, more imbalance in potential confounders, and greater than 10% change in effect estimates compared to the subgroup-specific approach. Therefore, examining covariate balance after matching to ensure that patient subgroups are balanced with respect to potential confounders is recommended if one of the full-cohort HDPS approaches are used. Advisors/Committee Members: Lee, Todd A (advisor), Calip, Gregory S (committee member), Leow, Alex D (committee member), Kim, Shiyun (committee member), Schumock, Glen T (committee member), Touchette, Daniel R (committee member), Lee, Todd A (chair).

Subjects/Keywords: Antipsychotic Agents High dimensional propensity score Depression Diabetes Comorbidity Pharmacoepidemiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Xing, S. (2017). Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Xing, Shan. “Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes.” 2017. Thesis, University of Illinois – Chicago. Accessed February 25, 2021. http://hdl.handle.net/10027/22207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Xing, Shan. “Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes.” 2017. Web. 25 Feb 2021.

Vancouver:

Xing S. Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10027/22207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xing S. Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Rao, Sapna V. Utilization Of Oral Anti-diabetic Medications: Examining Adherence To Clinical Guidelines.

Degree: 2012, University of Illinois – Chicago

The American Diabetes Association published a treatment algorithm for first line and second line drug therapy as a guide for physicians in treatment of type 2 diabetes mellitus. The level of concordance between clinical practice and the ADA guidelines has not been investigated. The effect of lab based evidence - impaired renal and liver function on physician prescribing behavior is not known. The aim of this study was to determine the degree of compliance of physician practice with the ADA guidelines and assess factors influencing these decisions. A retrospective cohort study of patients with diabetes managed at one of the clinics that provide routine diabetes care in University of Illinois Medical Center at Chicago was conducted for period from January 2007 to October 2010. Patients newly starting drug therapy were included in the study. Data from electronic prescription medication orders, laboratory data including serum creatinine, creatinine clearance, alanine aminotransferase, aspartate aminotransferase and hemoglobinA1c levels were used in the study. Patient demographics and all diagnosis data were also collected. Descriptive analysis of the data showed that physicians at UIMCC were compliant with the ADA guidelines about 72% of the time when they prescribed metformin as first line therapy adjusting for any liver or renal impairment status of the patient. The next most widely used drug as first line therapy was sulphonylureas followed by Insulin. A mixed effect regression model to identify predictors for prescribing metformin demonstrated that renal function, type of clinic and hemoglobin A1c levels were statistically significant variables. Patients with impaired liver function never got metformin. Patients with impaired renal function and higher haemoglobinA1c levels were less likely to receive metformin. Patients seen at the family medicine clinic were more likely to receive metformin than those seen at internal medicine or geriatric clinic. This single site study is the first to document the compliance of physicians with the ADA guidelines and assess the effects of patient’s clinical condition on prescribing behavior. It shows that physicians consider label information in their decision making process. Understanding these factors can help in defining the second line therapy towards a more streamlined management of diabetes. Advisors/Committee Members: Lambert, Bruce L. (advisor), Galanter, William L. (committee member), Touchette, Daniel R. (committee member), Shaw, James W. (committee member).

Subjects/Keywords: Type 2 diabetes; adherence, therapy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rao, S. V. (2012). Utilization Of Oral Anti-diabetic Medications: Examining Adherence To Clinical Guidelines. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/8957

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Rao, Sapna V. “Utilization Of Oral Anti-diabetic Medications: Examining Adherence To Clinical Guidelines.” 2012. Thesis, University of Illinois – Chicago. Accessed February 25, 2021. http://hdl.handle.net/10027/8957.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Rao, Sapna V. “Utilization Of Oral Anti-diabetic Medications: Examining Adherence To Clinical Guidelines.” 2012. Web. 25 Feb 2021.

Vancouver:

Rao SV. Utilization Of Oral Anti-diabetic Medications: Examining Adherence To Clinical Guidelines. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10027/8957.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rao SV. Utilization Of Oral Anti-diabetic Medications: Examining Adherence To Clinical Guidelines. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/8957

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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