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You searched for +publisher:"University of Illinois – Chicago" +contributor:("Gatenby, Robert A."). Showing records 1 – 2 of 2 total matches.

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University of Illinois – Chicago

1. Lloyd, Mark C. An Evolutionary and Ecological Investigation of Cancer.

Degree: 2016, University of Illinois – Chicago

I propose to investigate how Darwinian dynamics, as defined as the simultaneous evolution of populations and strategies on a continuous adaptive landscape, applies to cancer [Vincent 2005]. I am interested in investigating how and why intratumoral spatial heterogeneity of cancer cell populations, although sometimes initiated by random mutations, must be governed by identifiable Darwinian dynamics [Santos 2006, Gillies 2012]. My central hypothesis is that the physical morphology of cancer cells, which can be observed and quantified, provides deep insight into adaptations governed by variations in selection forces within local microenvironments. Furthermore, I submit that an evaluation of the evolution of cancer’s intratumoral heterogeneity is not chaotic or unpredictable, but can be understood by identifying regional variations in selection forces and adaptive strategies [Lloyd 2014]. Advisors/Committee Members: Brown, Joel S. (advisor), Mason-Gamer, Roberta J. (committee member), Minor, Emily S. (committee member), Gatenby, Robert A. (committee member), Bui, Marilyn M. (committee member).

Subjects/Keywords: ecology; cancer; evolution; heterogeneity; natural selection; regional variations; adaptive strategies; microenvironment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lloyd, M. C. (2016). An Evolutionary and Ecological Investigation of Cancer. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/20881

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lloyd, Mark C. “An Evolutionary and Ecological Investigation of Cancer.” 2016. Thesis, University of Illinois – Chicago. Accessed April 22, 2021. http://hdl.handle.net/10027/20881.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lloyd, Mark C. “An Evolutionary and Ecological Investigation of Cancer.” 2016. Web. 22 Apr 2021.

Vancouver:

Lloyd MC. An Evolutionary and Ecological Investigation of Cancer. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10027/20881.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lloyd MC. An Evolutionary and Ecological Investigation of Cancer. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/20881

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Orlando, Paul A. The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer.

Degree: 2012, University of Illinois – Chicago

I use consumer resource theory and evolutionary game theory in developing theory with regards to physiology, protists, and viruses. I use differential equation consumer resource systems to provide an ecological basis for theoretical exploration. And I use game theory to model natural selection within an ecological context. I investigate the effects of stoichiometric constraints on consumers in a graphical framework. I found that when stoichiometry is integrated into consumer resource models, ecological communities take on a more complex array of possible states. When resource equilibrium abundances are low, ecological communities are nearly identical to those used to characterize animal communities based on substitutable resources. However, when resource equilibrium abundances are high, ecological communities are similar to those used to characterize plant communities based on essential resources. I investigate the effects of species that can switch trophic levels by a morphologic transformation on ecological communities. I found that these species often stabilize population dynamics, which favors each morph as a separate species. I conclude that switching species likely evolve in environments with stochastic resource fluctuations or extrinsic drivers of resource levels. I also found that although switching species can fill diverse ecological niches in a community, they do not necessarily restrict diversity. I investigate the role of digestive physiology coupled with the digestive properties of resources in structuring ecological communities. I found that bulky resources select for large guts with long throughput times, and high energy/volume resources select for small guts and short throughput times. Most resource pairs lead to the evolution of a specialist on the richer resource followed by the invasion and evolution of a generalist. I also applied theory to HPV induced cancers. I hypothesized that HPV faces a life history tradeoff, where HR HPV is persistent but not very infectious, and vice versa for low-risk HPV. We found that different sexual subcultures within the human population could explain the origin and maintenance of these distinct HPV types. Furthermore, I made a PDE model of HPV infection within mucosal tissue to discover the links between cell population dynamics and HPV protein expression. And how somatic evolution of cells produces tissue level changes. I found that HPV’s proteins likely increase the density of tissue at which cells can divide and possibly also slow the migration rate of cells to the skin surface. I also found that somatic evolution is an alternative explanation for tissue level changes observed during high-risk HPV infection. Advisors/Committee Members: Brown, Joel S. (advisor), Mitchell, William A. (committee member), Grande, Terry (committee member), Buhse, Howard E. (committee member), Whelan, Christopher J. (committee member), Nyberg, Dennis W. (committee member), Gatenby, Robert A. (committee member).

Subjects/Keywords: Evolutionary game theory; Consumer-reosurce model; Community structure; Ecological stoichiometry; Polymorphic species; Human Papillomavirus; Oncogenic Virus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Orlando, P. A. (2012). The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/9573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Orlando, Paul A. “The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer.” 2012. Thesis, University of Illinois – Chicago. Accessed April 22, 2021. http://hdl.handle.net/10027/9573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Orlando, Paul A. “The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer.” 2012. Web. 22 Apr 2021.

Vancouver:

Orlando PA. The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10027/9573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Orlando PA. The Evolutionary ecology of physiological constraints in ecological communities and HPV-induced cancer. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/9573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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