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You searched for +publisher:"University of Florida" +contributor:("Scornik, Juan C"). One record found.

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University of Florida

1. Casey, Michael Jin. Delayed Immunosuppression Withdrawal Preserves Nonsensitization Status after Kidney Transplant Failure.

Degree: Medical Sciences
Clinical Investigation (IDP), 2012, University of Florida

When kidney transplants fail, transplant medications are stopped to reduce risks associated with immunosuppression. However, retransplantation candidates are at high risk for sensitization which delayed immunosuppression withdrawal may minimize. We hypothesize that for patients with graft failure referred for retransplantation, delayed immunosuppression withdrawal preserves nonsensitization (PRA 0%) better than early immunosuppression withdrawal.   We retrospectively examined subjects transplanted at a single center between Aug. 1999 and Jan. 2011 with non-death related graft loss. Subjects were stratified by time to immunosuppression withdrawal after graft loss: >3 months, 1-3 months, and less than or equal to 1 month. Retransplant candidates were eligible for the main study where the primary outcome was nonsensitization at retransplantation evaluation. Subjects not referred for retransplantation were included in the safety analysis.   We found 102 patients, with 49 eligible for the main study. Nonsensitization rates at retransplantation evaluation were 66%, 38%, and 25% for immunosuppression withdrawal >3 months, 1-3 months, and less than or equal to 1 month respectively (p = 0.041).  After adjusting for cofactors such as blood transfusion and allograft nephrectomy, immunosuppression withdrawal >3 months remained significant for nonsensitization (adjusted odds ratio=5.09, 95% C.I. [1.09-23.72]). Mortality and infection-related death were not associated with delayed immunosuppression withdrawal in the main study group or total study population.   In this study, delayed immunosuppression withdrawal appears safe as a strategy to minimize sensitization in low risk retransplantation candidates. No adverse safety signals were seen, but further investigation with larger sample size is needed. ( en ) Advisors/Committee Members: Nelson, David R (committee chair), Segal, Mark S (committee member), Scornik, Juan C (committee member).

Subjects/Keywords: immunosuppression  – kidney  – sensitization  – transplant  – withdrawal; Clinical Investigation (IDP)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Casey, M. J. (2012). Delayed Immunosuppression Withdrawal Preserves Nonsensitization Status after Kidney Transplant Failure. (Masters Thesis). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0045063

Chicago Manual of Style (16th Edition):

Casey, Michael Jin. “Delayed Immunosuppression Withdrawal Preserves Nonsensitization Status after Kidney Transplant Failure.” 2012. Masters Thesis, University of Florida. Accessed December 18, 2017. http://ufdc.ufl.edu/UFE0045063.

MLA Handbook (7th Edition):

Casey, Michael Jin. “Delayed Immunosuppression Withdrawal Preserves Nonsensitization Status after Kidney Transplant Failure.” 2012. Web. 18 Dec 2017.

Vancouver:

Casey MJ. Delayed Immunosuppression Withdrawal Preserves Nonsensitization Status after Kidney Transplant Failure. [Internet] [Masters thesis]. University of Florida; 2012. [cited 2017 Dec 18]. Available from: http://ufdc.ufl.edu/UFE0045063.

Council of Science Editors:

Casey MJ. Delayed Immunosuppression Withdrawal Preserves Nonsensitization Status after Kidney Transplant Failure. [Masters Thesis]. University of Florida; 2012. Available from: http://ufdc.ufl.edu/UFE0045063

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