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You searched for +publisher:"University of Florida" +contributor:("Lee, Choonsik "). Showing records 1 – 2 of 2 total matches.

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University of Florida

1. Hanlon, Justin. Computational Assessment of Effective Dose and Patient Specific Doses for Kilovoltage Stereotactic Radiosurgery of Wet Age-related Macular Degeneration.

Degree: PhD, Nuclear Engineering Sciences - Nuclear and Radiological Engineering, 2010, University of Florida

Age-related macular degeneration (AMD) is a leading cause of vision loss for people over the age of 50 in industrialized nations. Interest continues for stereotactic radiosurgery, a non-invasive treatment option for the wet form of AMD, through the development of the IRayTM (Oraya Therapeutics, Inc., Newark, CA). The goal of this modality is to destroy choroidal neovascularization beneath the pigment epithelium via three 100 kVp photon beams entering through the sclera and overlapping on the macula delivering up to 24 Gy of therapeutic dose over a span of approximately 5 minutes. A series of head phantoms was derived from CT data and employed in conjunction with the MCNPX 2.5.0 radiation transport code to simulate treatment and evaluate absorbed doses to potential tissues-at-risk. The results indicate that doses to non-targeted tissues were below thresholds for serious complications; specifically the development of cataracts and radiation-induced optic neuropathy. ( en ) Advisors/Committee Members: Bolch, Wesley E. (committee chair), Hintenlang, David E. (committee member), Sjoden, Glenn E. (committee member), Smith, Wesley C. (committee member), Chell, Erik (committee member), Lee, Choonsik (committee member).

Subjects/Keywords: Binocular vision; Dosage; Eyes; Geometric angles; Head; Optic nerve; Optics; Photons; Radiosurgery; Visual fixation; amd, anthropometric, dvh, fovea, macula, mcnpx, phantom, radiosurgery, stereotactic, voxel

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hanlon, J. (2010). Computational Assessment of Effective Dose and Patient Specific Doses for Kilovoltage Stereotactic Radiosurgery of Wet Age-related Macular Degeneration. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0041964

Chicago Manual of Style (16th Edition):

Hanlon, Justin. “Computational Assessment of Effective Dose and Patient Specific Doses for Kilovoltage Stereotactic Radiosurgery of Wet Age-related Macular Degeneration.” 2010. Doctoral Dissertation, University of Florida. Accessed January 29, 2020. http://ufdc.ufl.edu/UFE0041964.

MLA Handbook (7th Edition):

Hanlon, Justin. “Computational Assessment of Effective Dose and Patient Specific Doses for Kilovoltage Stereotactic Radiosurgery of Wet Age-related Macular Degeneration.” 2010. Web. 29 Jan 2020.

Vancouver:

Hanlon J. Computational Assessment of Effective Dose and Patient Specific Doses for Kilovoltage Stereotactic Radiosurgery of Wet Age-related Macular Degeneration. [Internet] [Doctoral dissertation]. University of Florida; 2010. [cited 2020 Jan 29]. Available from: http://ufdc.ufl.edu/UFE0041964.

Council of Science Editors:

Hanlon J. Computational Assessment of Effective Dose and Patient Specific Doses for Kilovoltage Stereotactic Radiosurgery of Wet Age-related Macular Degeneration. [Doctoral Dissertation]. University of Florida; 2010. Available from: http://ufdc.ufl.edu/UFE0041964


University of Florida

2. Wayson, Michael B. Computational Internal Dosimetry Methods as Applied to the University of Florida Series of Hybrid Phantoms.

Degree: PhD, Biomedical Engineering, 2012, University of Florida

Two primary areas of consideration for dosimetry of nuclear medicine imaging and therapy procedures are (1) the organ absorbed dose calculations, taking into account size, shape, and proximity of all internal organs as well as the energy and type of radiation emitted, and (2) the biokinetic models, taking into account how the radiopharmaceutical distributes throughout the body as a function of time.  This study focuses on methods used to estimate radiation absorbed dose to organs of the human body from internal radiation emitting nuclides.  Estimating absorbed dose to human tissues from radiations emitted from inside the body is known as internal dosimetry and is an integral part of performing risk assessment for the induction of secondary cancers, nuclear medicine image optimization, and limitation of dose to non-targeted organs in radiopharmaceutical therapy. This study developed a new system of blood vessels and blood dosimetry model, and the subsequent iteration of phantoms represents the latest University of Florida (UF) hybrid computational phantom (computerized representation of the human body) family.  Skeletal photon fluence-to-dose response functions were computed for the pediatric and adolescent series of UF phantoms to allow for the determination of absorbed dose to the skeletal tissues at risk for radiogenic leukemia and osteosarcoma. A complete set of photon and electron specific absorbed fractions (SAFs)were computed for the entire family of UF phantoms.  SAFs are used with radiopharmaceutical biokinetic data to determine individual organ doses.  Variations in radiation absorbed dose with changes in source and target organ masses, and source and target organ separation, and body habitus were investigated. These dosimetric sensitivity studies led to useful dose scaling methods for individual patients when patient-specific imaging-based methods of internal dosimetry are not available.  Results of the SAF calculations and scaling methodologies can be incorporated into software, thus facilitating their ease of use. Improvements in the accuracy of internal dose estimates allows for optimization of nuclear medicine imaging procedures and assessment of dose to normal tissues at risk during molecular radiotherapy procedures. In all cases, effectively balancing radiation dose with adequacy of clinical outcomes can be better achieved with more accurate patient dose estimates. ( en ) Advisors/Committee Members: Bolch, Wesley E (committee chair), Gilland, David R (committee member), Hintenlang, David E (committee member), Hagen, Stephen J (committee member), Sgouros, George (committee member), Lee, Choonsik (committee member).

Subjects/Keywords: Blood; Blood vessels; Body tissues; Bones; Dosage; Dosimetry; Electrons; Liver; Photons; Simulations; beta  – cancer  – computational  – dosimetry  – electron  – imaging  – internal  – medicine  – morphometry  – nuclear  – phantom  – photon  – radiopharmaceutical  – saf  – sensitivity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wayson, M. B. (2012). Computational Internal Dosimetry Methods as Applied to the University of Florida Series of Hybrid Phantoms. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0044569

Chicago Manual of Style (16th Edition):

Wayson, Michael B. “Computational Internal Dosimetry Methods as Applied to the University of Florida Series of Hybrid Phantoms.” 2012. Doctoral Dissertation, University of Florida. Accessed January 29, 2020. http://ufdc.ufl.edu/UFE0044569.

MLA Handbook (7th Edition):

Wayson, Michael B. “Computational Internal Dosimetry Methods as Applied to the University of Florida Series of Hybrid Phantoms.” 2012. Web. 29 Jan 2020.

Vancouver:

Wayson MB. Computational Internal Dosimetry Methods as Applied to the University of Florida Series of Hybrid Phantoms. [Internet] [Doctoral dissertation]. University of Florida; 2012. [cited 2020 Jan 29]. Available from: http://ufdc.ufl.edu/UFE0044569.

Council of Science Editors:

Wayson MB. Computational Internal Dosimetry Methods as Applied to the University of Florida Series of Hybrid Phantoms. [Doctoral Dissertation]. University of Florida; 2012. Available from: http://ufdc.ufl.edu/UFE0044569

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