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You searched for +publisher:"University of Colorado" +contributor:("Richard McIntosh"). One record found.

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University of Colorado

1. Edelmaier, Christopher. Computational Modeling of Mitosis in Fission Yeast.

Degree: PhD, 2018, University of Colorado

Mitosis ensures the proper segregation of chromosomes into daughter cells, which is accomplished by the mitotic spindle. During fission yeast mitosis, chromosomes establish bi-orientation as the bipolar spindle assembles, meaning that sister kinetochores become attached to microtubules whose growth was initiated by the two sister poles. This process includes mechanisms that correct erroneous attachments made by the kinetochores during the attachment process. This thesis presents a 3D physical model of spindle assembly in a Brownian dynamics-kinetic Monte Carlo simulation framework and a realistic description of the physics of microtubule, kinetochore, and chromosome dynamics, in order to interrogate the dynamics and mechanisms of chromosome bi-orientation and error correction. We have added chromosomes to our previous physical model of spindle assembly, which included microtubules, a spherical nuclear envelope, motor proteins, crosslinking proteins, and spindle pole bodies (centrosomes). In this work, we have explored the mechanical properties of kinetochores and their interactions with microtubules that achieve amphitelic spindle attachments at high frequency. A minimal physical model yields simulations that generate chromosome attachment errors, but resolves them, much as normal chromosomes do. Advisors/Committee Members: Meredith D. Betterton, Matthew A. Glaser, Loren Hough, Thomas Perkins, Richard McIntosh.

Subjects/Keywords: computational; fission; mitosis; nonequilibrium; yeast; Biophysics; Cellular and Molecular Physiology; Statistical, Nonlinear, and Soft Matter Physics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Edelmaier, C. (2018). Computational Modeling of Mitosis in Fission Yeast. (Doctoral Dissertation). University of Colorado. Retrieved from https://scholar.colorado.edu/phys_gradetds/237

Chicago Manual of Style (16th Edition):

Edelmaier, Christopher. “Computational Modeling of Mitosis in Fission Yeast.” 2018. Doctoral Dissertation, University of Colorado. Accessed March 05, 2021. https://scholar.colorado.edu/phys_gradetds/237.

MLA Handbook (7th Edition):

Edelmaier, Christopher. “Computational Modeling of Mitosis in Fission Yeast.” 2018. Web. 05 Mar 2021.

Vancouver:

Edelmaier C. Computational Modeling of Mitosis in Fission Yeast. [Internet] [Doctoral dissertation]. University of Colorado; 2018. [cited 2021 Mar 05]. Available from: https://scholar.colorado.edu/phys_gradetds/237.

Council of Science Editors:

Edelmaier C. Computational Modeling of Mitosis in Fission Yeast. [Doctoral Dissertation]. University of Colorado; 2018. Available from: https://scholar.colorado.edu/phys_gradetds/237

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