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You searched for +publisher:"University of Arizona" +contributor:("Kuo, Phillip H."). Showing records 1 – 2 of 2 total matches.

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University of Arizona

1. Lindeman, Leila Renee. Improving the Specificity of Lung Cancer Diagnosis with acidoCEST MRI .

Degree: 2018, University of Arizona

Acido-Chemical Exchange Saturation Transfer (acidoCEST) Magnetic Resonance Imaging (MRI) is a non-invasive method for creating spatial maps of the extracellular pH (pHe) in solid tissues in vivo. Cancer cells are known to export increased quantities of lactic acid into the extracellular space as a result of glycolytic metabolic processes. Localized tissue acidosis can therefore function as a cancer biomarker, and acidoCEST MRI may be an impactful tool for increasing the specificity of imaging results. My work has focused on applying acidoCEST MRI to the diagnosis of lung cancer, where low-dose CT screening tests have a false positive rate of 95%. Chapter 1 discusses recent advances in MRI for the diagnosis, prognosis and management of pulmonary disease. Chapter 2 refers to a published manuscript reprinted in Appendix A which describes a method comparison study wherein I determined that the exchange rate (kex) of amide protons quantified by endogenous CEST MRI could not serve as a proxy measurement for pHe quantified by acidoCEST MRI. Chapter 3 describes a study in which I determined that lung tumors and valley fever granulomas in preclinical murine models have significantly different pHe. Chapter 4 discusses future directions of inquiry towards diagnostic CEST MRI methods for lung cancer including: application of endogenous CEST MRI, further development of the BSL-2 compatible murine valley fever model, and potential improvements to acidoCEST MRI image acquisition and analysis methods to aid in future clinical translation. Advisors/Committee Members: Pagel, Mark D (advisor), Briehl, Margaret M. (committeemember), Kuo, Phillip H. (committeemember), Roe, Denise J. (committeemember), Hsu, Chiu-Hsieh (committeemember).

Subjects/Keywords: Cancer Biology; Cancer Imaging; Coccidioidomycosis; Tumor Acidosis; Tumor Microenvironmnt

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lindeman, L. R. (2018). Improving the Specificity of Lung Cancer Diagnosis with acidoCEST MRI . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/628015

Chicago Manual of Style (16th Edition):

Lindeman, Leila Renee. “Improving the Specificity of Lung Cancer Diagnosis with acidoCEST MRI .” 2018. Doctoral Dissertation, University of Arizona. Accessed November 21, 2019. http://hdl.handle.net/10150/628015.

MLA Handbook (7th Edition):

Lindeman, Leila Renee. “Improving the Specificity of Lung Cancer Diagnosis with acidoCEST MRI .” 2018. Web. 21 Nov 2019.

Vancouver:

Lindeman LR. Improving the Specificity of Lung Cancer Diagnosis with acidoCEST MRI . [Internet] [Doctoral dissertation]. University of Arizona; 2018. [cited 2019 Nov 21]. Available from: http://hdl.handle.net/10150/628015.

Council of Science Editors:

Lindeman LR. Improving the Specificity of Lung Cancer Diagnosis with acidoCEST MRI . [Doctoral Dissertation]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/628015


University of Arizona

2. Jones, Kyle M. Improving the Accuracy and Precision of Chemical Exchange Saturation Transfer (CEST) MRI .

Degree: 2016, University of Arizona

Chemical exchange saturation transfer (CEST) MRI has the ability to noninvasively measure endogenous biomarkers and exogenous agents relevant to various diseases and medical conditions. My work has focused on the development of MRI pulse sequences and data analysis methods to more accurately estimate endogenous and exogenous CEST contrast measurements at 7 T and 3 T magnetic field strengths. Chapter 1 discusses the various sources of signal that have been measured with CEST MRI in the clinic, the acquisition methods used to acquire these signals, and the data analysis methods used to quantify the CEST effects from these signals. Appendix A describes the development of a respiration gated CEST pulse sequence that was ultimately used with a lung fibrosis mouse model to measure extracellular pH (pHe) of the fibrotic lesions. Appendix B describes the development of a data processing algorithm that used the Bloch equations modified for chemical exchange to generate more accurate and precise pHe estimates both at 7 T and 3 T magnetic field strengths relative to a previous data processing algorithm. Appendix C describes the development of a retrospective gating technique for the lung that generates more accurate and precise endogenous CEST contrast measurements. Advisors/Committee Members: Pagel, Mark D (advisor), Pagel, Mark D. (committeemember), Kuo, Phillip H. (committeemember), Matsunaga, Terry O. (committeemember), Hamilton, Russell J. (committeemember).

Subjects/Keywords: Chemical Exchange Saturation Transfer; Extracellular pH; Tumor; Biomedical Engineering; Biomedical Imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jones, K. M. (2016). Improving the Accuracy and Precision of Chemical Exchange Saturation Transfer (CEST) MRI . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/621793

Chicago Manual of Style (16th Edition):

Jones, Kyle M. “Improving the Accuracy and Precision of Chemical Exchange Saturation Transfer (CEST) MRI .” 2016. Doctoral Dissertation, University of Arizona. Accessed November 21, 2019. http://hdl.handle.net/10150/621793.

MLA Handbook (7th Edition):

Jones, Kyle M. “Improving the Accuracy and Precision of Chemical Exchange Saturation Transfer (CEST) MRI .” 2016. Web. 21 Nov 2019.

Vancouver:

Jones KM. Improving the Accuracy and Precision of Chemical Exchange Saturation Transfer (CEST) MRI . [Internet] [Doctoral dissertation]. University of Arizona; 2016. [cited 2019 Nov 21]. Available from: http://hdl.handle.net/10150/621793.

Council of Science Editors:

Jones KM. Improving the Accuracy and Precision of Chemical Exchange Saturation Transfer (CEST) MRI . [Doctoral Dissertation]. University of Arizona; 2016. Available from: http://hdl.handle.net/10150/621793

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