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You searched for +publisher:"University of Alabama – Birmingham" +contributor:("Lorenz, Robinna<br>"). One record found.

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1. Szafran, April Adams. The use of molecular imaging to evaluate the efficacy of treatments for metastatic breast cancer.

Degree: PhD, 2008, University of Alabama – Birmingham

The development of molecular imaging technologies has allowed biomedical researchers to study the process of cancer metastasis in animal models of disease. Bioluminescence imaging has been a crucial tool for non-invasive monitoring of tumor growth, dissemination, and response to therapies. In this report, we have applied bioluminescence imaging to evaluate the efficacy of Death Receptor 5 agonist therapy for the treatment of breast cancer metastasis, predominately to the skeleton, in an athymic nude mouse model. Initially, we determined that bioluminescence imaging was the most ideal technology for studying secondary bone lesions in vivo when compared to both x-ray Computed Tomography and SPECT-CT imaging. Through analysis of histologic sections, bioluminescent images, and markers of bone resorption, therapy studies revealed that murine death receptor 5 agonist mTRA8 and its humanized version hTRA8 significantly reduce tumor burden in mice with experimental metastatic lesions in osseous tissues when combined with zoledronic acid. In a second study, mTRA8 resulted in a significant amount of tumor regression in an in vivo model of lung metastasis. From this work we have concluded that Death Receptor 5 agonist therapy is a promising treatment for breast cancer metastasis in animal models of this human disease and should be evaluated in a clinical setting.

1 online resource (xi, 102 p. : ill., digital, PDF file)

Pathology;

Joint Health Sciences;

breast cancer apoptosis molecular imaging metastasis drug therapy

UNRESTRICTED

Advisors/Committee Members: Zinn, Kurt R., Buchsbaum, Donald J.<br>, Feng, Xu<br>, Grubbs, Clinton<br>, Lorenz, Robinna<br>, Selander, Katri.

Subjects/Keywords: Antibodies, Monoclonal  – pharmacology<; br>; Antineoplastic Combined Chemotherapy<; br>; Protocols  – pharmacology<; br>; Bone Neoplasms<; br>; Breast Neoplasms<; br>; Diphosphonates  – pharmacology<; br>; Imidazoles  – pharmacology<; br>; Mammary Neoplasms, Experimental  – pathology<; br>; Receptors, TNF-Related Apoptosis-Inducing Ligand  – agonists

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Szafran, A. A. (2008). The use of molecular imaging to evaluate the efficacy of treatments for metastatic breast cancer. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,927

Chicago Manual of Style (16th Edition):

Szafran, April Adams. “The use of molecular imaging to evaluate the efficacy of treatments for metastatic breast cancer.” 2008. Doctoral Dissertation, University of Alabama – Birmingham. Accessed March 29, 2020. http://contentdm.mhsl.uab.edu/u?/etd,927.

MLA Handbook (7th Edition):

Szafran, April Adams. “The use of molecular imaging to evaluate the efficacy of treatments for metastatic breast cancer.” 2008. Web. 29 Mar 2020.

Vancouver:

Szafran AA. The use of molecular imaging to evaluate the efficacy of treatments for metastatic breast cancer. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2008. [cited 2020 Mar 29]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,927.

Council of Science Editors:

Szafran AA. The use of molecular imaging to evaluate the efficacy of treatments for metastatic breast cancer. [Doctoral Dissertation]. University of Alabama – Birmingham; 2008. Available from: http://contentdm.mhsl.uab.edu/u?/etd,927

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